2022
Dickkopf1 fuels inflammatory cytokine responses
Jaschke N, Pählig S, Sinha A, Adolph T, Colunga M, Hofmann M, Wang A, Thiele S, Schwärzler J, Kleymann A, Gentzel M, Tilg H, Wielockx B, Hofbauer L, Rauner M, Göbel A, Rachner T. Dickkopf1 fuels inflammatory cytokine responses. Communications Biology 2022, 5: 1391. PMID: 36539532, PMCID: PMC9765382, DOI: 10.1038/s42003-022-04368-8.Peer-Reviewed Original ResearchConceptsInflammatory cytokine responseCytokine responsesCell-autonomous functionCell-autonomous mechanismsElevated cytokine productionMolecular underpinningsNon-malignant cellsCytokine receptorsHuman diseasesPharmacological neutralizationInflammatory toneInflammatory componentCytokine productionCancer cellsGenetic deletionInflammatory responseRelA activityDKK1Mouse modelDisease trajectoriesHealthy populationCell modelAdditional studiesInflammationCells
2019
GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance
Luan HH, Wang A, Hilliard B, Carvalho F, Rosen CE, Ahasic A, Herzog E, Kang I, Pisani MA, Yu S, Zhang C, Ring A, Young L, Medzhitov R. GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance. Cell 2019, 178: 1231-1244.e11. PMID: 31402172, PMCID: PMC6863354, DOI: 10.1016/j.cell.2019.07.033.Peer-Reviewed Original ResearchConceptsViral infectionTriglyceride metabolismImpaired cardiac functionRole of GDF15Differentiation factor 15Plasma triglyceride levelsSympathetic outflowInflammatory damageTriglyceride levelsCardiac functionInflammatory responseExogenous administrationProtective effectFactor 15GDF15Central mediatorTissue toleranceBody temperatureInfectionMetabolismSepsisInflammationAdministrationHormone