Metabolomic Analysis of the Effects of Leptin Replacement Therapy in Patients with Lipodystrophy
Grewal S, Gubbi S, Fosam A, Sedmak C, Sikder S, Talluru H, Brown R, Muniyappa R. Metabolomic Analysis of the Effects of Leptin Replacement Therapy in Patients with Lipodystrophy. Journal Of The Endocrine Society 2019, 4: bvz022. PMID: 32010873, PMCID: PMC6984783, DOI: 10.1210/jendso/bvz022.Peer-Reviewed Original ResearchLeptin replacement therapyOral glucose tolerance testGlucose tolerance testReplacement therapyLeptin therapyTolerance testLeptin-deficient patientsDramatic clinical effectsMetabolomic profilingTumor necrosis factorForms of lipodystrophyHydroxysteroid dehydrogenase 1Body composition measurementsBranched-chain amino acidsBranched-chain amino acid metabolismFatty acid oxidationMetabolomic analysisMechanism of actionMetreleptin therapyClinical effectsFatty acidsLeptin treatmentNecrosis factorTreatment periodFree fatty acids