2021
Insulin sensitivity and pancreatic β-cell function in patients with primary aldosteronism
Grewal S, Fosam A, Chalk L, Deven A, Suzuki M, Correa R, Blau J, Demidowich A, Stratakis C, Muniyappa R. Insulin sensitivity and pancreatic β-cell function in patients with primary aldosteronism. Endocrine 2021, 72: 96-103. PMID: 33462741, PMCID: PMC8087621, DOI: 10.1007/s12020-020-02576-y.Peer-Reviewed Original ResearchConceptsΒ-cell functionHepatic insulin resistance indexOral glucose tolerance testPancreatic β-cell functionInsulin sensitivityInsulinogenic indexDisposition indexEffects of hyperaldosteronismCross-sectional study designInsulin resistance indexGlucose tolerance testOral disposition indexSimilar glucose toleranceBackgroundPrimary aldosteronismExcess aldosteronePA cohortArterial pressurePrimary aldosteronismGlucose toleranceControl subjectsTolerance testLess insulinResistance indexPA subjectsInsulin action
2020
Increased β-Cell Responsivity Independent of Insulin Sensitivity in Healthy African American Adults
Armiyaw L, Sarcone C, Fosam A, Muniyappa R. Increased β-Cell Responsivity Independent of Insulin Sensitivity in Healthy African American Adults. The Journal Of Clinical Endocrinology & Metabolism 2020, 105: dgaa234. PMID: 32382759, PMCID: PMC7266075, DOI: 10.1210/clinem/dgaa234.Peer-Reviewed Original ResearchConceptsNon-Hispanic whitesTotal β-cell responsivityΒ-cell responsivityPrimary insulin hypersecretionGlucose disposal rateInsulin sensitivityInsulin hypersecretionAfrican AmericansBasal insulin secretion rateGlucose responsivityIntravenous glucose tolerance testGlucose tolerance testHyperinsulinemic euglycemic glucose clamp techniqueC-peptide secretionGlucose clamp techniqueInsulin secretion rateNondiabetic African AmericansΒ-cell functionAfrican American adultsInsulin resistanceTolerance testNHW subjectsC-peptideInsulin secretionSignificant ethnic differencesOR08-05 Sex and Ethnic Differences in Advanced Lipoprotein Profiles in South Asians, African-Americans, and Caucasians
Sarcone C, Fosam A, Armiyaw A, Grewal S, Bansal R, Rabel A, Muniyappa R. OR08-05 Sex and Ethnic Differences in Advanced Lipoprotein Profiles in South Asians, African-Americans, and Caucasians. Journal Of The Endocrine Society 2020, 4: or08-05. PMCID: PMC7208063, DOI: 10.1210/jendso/bvaa046.1428.Peer-Reviewed Original ResearchLow-density lipoprotein particlesHDL particle numberTriglyceride-rich lipoprotein particlesLipoprotein profileHigh-density lipoprotein particlesSA menLipoprotein particlesInsulin resistanceInsulin sensitivityCA menCardiovascular diseaseSouth AsiansAfrican AmericansEthnic differencesCholesteryl ester transfer protein activityIntravenous glucose tolerance testAdvanced lipoprotein profileStandard lipid panelLDL particle numberAtherogenic lipoprotein profileGlucose tolerance testCross-sectional studyApoA-I levelsHDL particle sizeFat-free massSAT-624 Predictive Ability of Lipoprotein Insulin Resistance (LPIR) Score in South Asians: A Comparison of Surrogate Indices of Insulin Sensitivity/Resistance
Fosam A, Grewal S, Armiyaw A, Sarcone C, Rabel A, Auh S, Muniyappa R. SAT-624 Predictive Ability of Lipoprotein Insulin Resistance (LPIR) Score in South Asians: A Comparison of Surrogate Indices of Insulin Sensitivity/Resistance. Journal Of The Endocrine Society 2020, 4: sat-624. PMCID: PMC7209077, DOI: 10.1210/jendso/bvaa046.1740.Peer-Reviewed Original ResearchLipoprotein insulin resistance scoreInsulin resistance scoreInsulin resistanceLPIR scoreSurrogate indexSouth AsiansInsulin sensitivity/resistanceIntravenous glucose tolerance testGlucose tolerance testLipoprotein particle concentrationsInsulin-resistant individualsType 2 diabetesInsulin-resistant subjectsCross-sectional studyInsulin-resistant statesCharacteristic curve analysisMinimal model analysisResistance scoreSensitivity/resistanceHOMA-IRLipoprotein abnormalitiesTolerance testInsulin sensitivityHigh riskResistant subjectsSAT-651 Ethnic Differences in the Relationship Between Uric Acid Clearance and Insulin Sensitivity
Armiyaw A, Fosam A, Sarcone C, Aradhya A, Walter M, Rabel A, Muniyappa R. SAT-651 Ethnic Differences in the Relationship Between Uric Acid Clearance and Insulin Sensitivity. Journal Of The Endocrine Society 2020, 4: sat-651. PMCID: PMC7209748, DOI: 10.1210/jendso/bvaa046.1820.Peer-Reviewed Original ResearchIntravenous glucose tolerance testInsulin-resistant statesFractional excretionInsulin sensitivityUA clearanceUric acidAfrican AmericansUA productionGlucose tolerance testUric acid clearanceSpot urine samplesType 2 diabetesUrinary uric acidCross-sectional studyEthnic differencesPlasma uric acidPercent body fatPathogenesis of hyperuricemiaUric acid productionAcid clearanceCreatinine ratioDiastolic BPHigher BMIUA levelsTolerance test
2019
Metabolomic Analysis of the Effects of Leptin Replacement Therapy in Patients with Lipodystrophy
Grewal S, Gubbi S, Fosam A, Sedmak C, Sikder S, Talluru H, Brown R, Muniyappa R. Metabolomic Analysis of the Effects of Leptin Replacement Therapy in Patients with Lipodystrophy. Journal Of The Endocrine Society 2019, 4: bvz022. PMID: 32010873, PMCID: PMC6984783, DOI: 10.1210/jendso/bvz022.Peer-Reviewed Original ResearchLeptin replacement therapyOral glucose tolerance testGlucose tolerance testReplacement therapyLeptin therapyTolerance testLeptin-deficient patientsDramatic clinical effectsMetabolomic profilingTumor necrosis factorForms of lipodystrophyHydroxysteroid dehydrogenase 1Body composition measurementsBranched-chain amino acidsBranched-chain amino acid metabolismFatty acid oxidationMetabolomic analysisMechanism of actionMetreleptin therapyClinical effectsFatty acidsLeptin treatmentNecrosis factorTreatment periodFree fatty acidsOR31-6 Insulin Sensitivity and Pancreatic Beta-Cell Function in Patients with Primary Aldosteronism
Grewal S, Fosam A, Chalk L, Deven A, Suzuki M, Demidowich A, Correa R, Blau J, Stratakis C, Muniyappa R. OR31-6 Insulin Sensitivity and Pancreatic Beta-Cell Function in Patients with Primary Aldosteronism. Journal Of The Endocrine Society 2019, 3: or31-6. PMCID: PMC6554914, DOI: 10.1210/js.2019-or31-6.Peer-Reviewed Original ResearchOral glucose tolerance testΒ-cell functionBeta-cell functionHepatic insulin resistance indexPancreatic beta-cell functionPrimary aldosteronismHepatic insulin sensitivityInsulin sensitivityInsulinogenic indexDisposition indexGlucose tolerancePA groupPancreatic β-cell functionIslet β-cell functionInsulin resistance indexMean arterial pressureGlucose tolerance testOral disposition indexType 2 diabetesSimilar glucose toleranceMinimal model analysisExcess aldosteronePA cohortElevated aldosteroneRenin levels