2014
In vitro evolution of high-titer, virus-like vesicles containing a single structural protein
Rose NF, Buonocore L, Schell JB, Chattopadhyay A, Bahl K, Liu X, Rose JK. In vitro evolution of high-titer, virus-like vesicles containing a single structural protein. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 16866-16871. PMID: 25385608, PMCID: PMC4250146, DOI: 10.1073/pnas.1414991111.Peer-Reviewed Original ResearchConceptsVirus-like vesiclesStructural proteinsCapsid proteinCell surfaceLate domain motifsVesicular stomatitis virus glycoproteinVSV G proteinPlasmid-based systemOnly structural proteinSingle structural proteinDomain motifReplicase proteinsReplication factoriesMultiple point mutationsExtensive passagingG proteinsRNA repliconsRNA virusesPoint mutationsProteinEfficient packagingInnate immunityMutationsVirus glycoproteinVesicles
2008
Hybrid alphavirus–rhabdovirus propagating replicon particles are versatile and potent vaccine vectors
Rose NF, Publicover J, Chattopadhyay A, Rose JK. Hybrid alphavirus–rhabdovirus propagating replicon particles are versatile and potent vaccine vectors. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 5839-5843. PMID: 18391206, PMCID: PMC2311333, DOI: 10.1073/pnas.0800280105.Peer-Reviewed Original ResearchConceptsCellular immune responsesImmune responseVaccine vectorStrong cellular immune responsesPotent vaccine vectorSubsequent lethal challengeInduction of antibodiesSafe vaccine vectorSingle doseLethal challengeReplicon particlesHigh titersPotent inducerVirus-like particlesViral structural proteinsAntibodiesInfectious particlesCell linesVirus glycoproteinRNA repliconsRNA replicationVesicular stomatitis virus glycoproteinVSVAnimal cell linesStructural proteins