2021
Cytochrome b Drug Resistance Mutation Decreases Babesia Fitness in the Tick Stages But Not the Mammalian Erythrocytic Cycle
Chiu JE, Renard I, George S, Pal A, Alday PH, Narasimhan S, Riscoe MK, Doggett JS, Mamoun C. Cytochrome b Drug Resistance Mutation Decreases Babesia Fitness in the Tick Stages But Not the Mammalian Erythrocytic Cycle. The Journal Of Infectious Diseases 2021, 225: 135-145. PMID: 34139755, PMCID: PMC8730496, DOI: 10.1093/infdis/jiab321.Peer-Reviewed Original ResearchConceptsMitochondrial cytochrome bParasite life cycleWild-type alleleTick vectorParasite fitnessCytochrome bMutant parasitesMutant allelesErythrocytic cycleArthropod vectorsNymphal stagesBabesia parasitesMutationsLife cycleFitnessTick stagesResistance mutationsMalaria-like illnessB. microtiAllelesDrug resistance mutationsParasitesHuman babesiosisTicksHost
2014
In vitro evolution of high-titer, virus-like vesicles containing a single structural protein
Rose NF, Buonocore L, Schell JB, Chattopadhyay A, Bahl K, Liu X, Rose JK. In vitro evolution of high-titer, virus-like vesicles containing a single structural protein. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 16866-16871. PMID: 25385608, PMCID: PMC4250146, DOI: 10.1073/pnas.1414991111.Peer-Reviewed Original ResearchConceptsVirus-like vesiclesStructural proteinsCapsid proteinCell surfaceLate domain motifsVesicular stomatitis virus glycoproteinVSV G proteinPlasmid-based systemOnly structural proteinSingle structural proteinDomain motifReplicase proteinsReplication factoriesMultiple point mutationsExtensive passagingG proteinsRNA repliconsRNA virusesPoint mutationsProteinEfficient packagingInnate immunityMutationsVirus glycoproteinVesicles