2016
Recombinant vesicular stomatitis virus-based dengue-2 vaccine candidate induces humoral response and protects mice against lethal infection
Lauretti F, Chattopadhyay A, de Oliveira França RF, Castro-Jorge L, Rose J, da Fonseca BA. Recombinant vesicular stomatitis virus-based dengue-2 vaccine candidate induces humoral response and protects mice against lethal infection. Human Vaccines & Immunotherapeutics 2016, 12: 2327-2333. PMID: 27185081, PMCID: PMC5027729, DOI: 10.1080/21645515.2016.1183857.Peer-Reviewed Original ResearchConceptsVaccine candidatesBALB/c miceImportant arbovirus diseaseCellular immune responsesDENV-2 infectionDengue-2 virusDENV vaccineHemorrhagic casesVSV virusesSubcutaneous routeHumoral responseC miceClinical trialsLethal infectionImmune responseDENV-2Vaccine vectorControl groupVirus expressionVaccineE expressionMiceFirst inoculationLethal dosesChallenge experiments
2012
A Chimeric Vesiculo/Alphavirus Is an Effective Alphavirus Vaccine
Chattopadhyay A, Wang E, Seymour R, Weaver SC, Rose JK. A Chimeric Vesiculo/Alphavirus Is an Effective Alphavirus Vaccine. Journal Of Virology 2012, 87: 395-402. PMID: 23077320, PMCID: PMC3536361, DOI: 10.1128/jvi.01860-12.Peer-Reviewed Original ResearchConceptsChikungunya virusVesicular stomatitis virusChimeric vesicular stomatitis virusAlphavirus vaccinesCellular immune responsesAlphavirus chikungunya virusMosquito-transmitted alphavirusCHIKV glycoproteinsCHIKV infectionCHIKV vaccineLicensed vaccineSingle doseWorldwide epidemicChikungunya feverImmune responseExperimental vaccinesAlphavirus infectionMultiple recent outbreaksVaccineHigh titersChimeric virusesSerious human diseasesVSV glycoproteinVirusRecent outbreak
2008
Hybrid alphavirus–rhabdovirus propagating replicon particles are versatile and potent vaccine vectors
Rose NF, Publicover J, Chattopadhyay A, Rose JK. Hybrid alphavirus–rhabdovirus propagating replicon particles are versatile and potent vaccine vectors. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 5839-5843. PMID: 18391206, PMCID: PMC2311333, DOI: 10.1073/pnas.0800280105.Peer-Reviewed Original ResearchConceptsCellular immune responsesImmune responseVaccine vectorStrong cellular immune responsesPotent vaccine vectorSubsequent lethal challengeInduction of antibodiesSafe vaccine vectorSingle doseLethal challengeReplicon particlesHigh titersPotent inducerVirus-like particlesViral structural proteinsAntibodiesInfectious particlesCell linesVirus glycoproteinRNA repliconsRNA replicationVesicular stomatitis virus glycoproteinVSVAnimal cell linesStructural proteins