2020
Alcohol Use and Antiretroviral Adherence Among Patients Living with HIV: Is Change in Alcohol Use Associated with Change in Adherence?
Williams EC, McGinnis KA, Rubinsky AD, Matson TE, Bobb JF, Lapham GT, Edelman EJ, Satre DD, Catz SL, Richards JE, Bryant KJ, Marshall BDL, Kraemer KL, Crystal S, Gordon AJ, Skanderson M, Fiellin DA, Justice AC, Bradley KA. Alcohol Use and Antiretroviral Adherence Among Patients Living with HIV: Is Change in Alcohol Use Associated with Change in Adherence? AIDS And Behavior 2020, 25: 203-214. PMID: 32617778, PMCID: PMC7775874, DOI: 10.1007/s10461-020-02950-x.Peer-Reviewed Original ResearchMeSH KeywordsAgedAlcohol DrinkingAnti-Retroviral AgentsCohort StudiesFemaleHIV InfectionsHumansMaleMedication AdherenceMiddle AgedConceptsAlcohol useAntiretroviral therapyLow-level alcohol useInitial adherenceAntiretroviral adherenceAdherence interventionsAdherence decreasesAlcohol use increasesScreening scoresLongitudinal associationsAdherencePLWHHIVAnnual changesLinear regression modelsStable scoresRegression modelsScoresSmall annual changesDynamic longitudinal associationsAssociationUse increasesPatientsTherapy
2018
Gender and alcohol use
Matson TE, McGinnis KA, Rubinsky AD, Frost MC, Czarnogorski M, Bryant KJ, Edelman EJ, Satre DD, Catz SL, Bensley KM, Fiellin DA, Justice AC, Williams EC. Gender and alcohol use. AIDS 2018, 32: 2247-2253. PMID: 30005010, PMCID: PMC6136970, DOI: 10.1097/qad.0000000000001946.Peer-Reviewed Original ResearchConceptsAlcohol useHIV careViral suppressionART treatmentVeterans Aging Cohort Study (VACS) dataVeterans Health Administration patientsAUDIT-C alcoholHIV medical careHIV care continuumLarge national cohortCohort study dataPoisson regression modelsPrescribed ARTPrevalence of engagementRetrospective cohortNational cohortUS veteransWorse outcomesCare continuumRelative riskStratified analysisMedical careHIVGender modifiesWomenEfficacy of Extended-Release Naltrexone on HIV-Related and Drinking Outcomes Among HIV-Positive Patients: A Randomized-Controlled Trial
Edelman EJ, Moore BA, Holt SR, Hansen N, Kyriakides TC, Virata M, Brown ST, Justice AC, Bryant KJ, Fiellin DA, Fiellin LE. Efficacy of Extended-Release Naltrexone on HIV-Related and Drinking Outcomes Among HIV-Positive Patients: A Randomized-Controlled Trial. AIDS And Behavior 2018, 23: 211-221. PMID: 30073637, PMCID: PMC6476298, DOI: 10.1007/s10461-018-2241-z.Peer-Reviewed Original ResearchConceptsHIV-positive patientsHeavy drinking daysVACS Index scoreXR-NTXART adherenceDrinking daysIndex scoreUndetectable HIV viral loadCD4 cell countExtended-release naltrexoneDouble-blind placeboHIV viral loadRandomized-controlled trialDrinking outcomesHIV biomarkersSecondary outcomesHIV outcomesPrimary outcomeViral loadAntiretroviral adherenceClinical trialsCell countAlcohol treatmentHIVPatientsLevel of Alcohol Use Associated with HIV Care Continuum Targets in a National U.S. Sample of Persons Living with HIV Receiving Healthcare
Williams EC, McGinnis KA, Edelman EJ, Matson TE, Gordon AJ, Marshall BDL, Bryant KJ, Rubinsky AD, Lapham GT, Satre DD, Richards JE, Catz SL, Fiellin DA, Justice AC, Bradley KA. Level of Alcohol Use Associated with HIV Care Continuum Targets in a National U.S. Sample of Persons Living with HIV Receiving Healthcare. AIDS And Behavior 2018, 23: 140-151. PMID: 29995206, PMCID: PMC6344313, DOI: 10.1007/s10461-018-2210-6.Peer-Reviewed Original ResearchConceptsViral suppressionAlcohol use levelsART treatmentVeterans Aging Cohort Study (VACS) dataAlcohol useAUDIT-C screeningCare continuum outcomesHIV care continuumCohort study dataHigh-level drinkingPoisson regression modelsContinuum outcomesHIV treatmentAdjusted prevalenceCare engagementCare continuumGreater alcohol useHIVPatientsUse levelsTreatmentRegression modelsStudy dataNational U.S. sampleAssociation
2017
Ten-year trends in antiretroviral therapy persistence among US Medicaid beneficiaries
Youn B, Shireman TI, Lee Y, Galárraga O, Rana AI, Justice AC, Wilson IB. Ten-year trends in antiretroviral therapy persistence among US Medicaid beneficiaries. AIDS 2017, 31: 1697-1707. PMID: 28700393, PMCID: PMC5625296, DOI: 10.1097/qad.0000000000001541.Peer-Reviewed Original ResearchConceptsAngiotensin II receptor blockersII receptor blockersHIV patientsControl medicationTherapy persistenceReceptor blockersEnzyme inhibitors/angiotensin II receptor blockersCox proportional hazards modelNon-HIV medicationsUS Medicaid beneficiariesHIV-negative controlsRetrospective cohort studyKaplan-Meier curvesDuration of treatmentProportional hazards modelTen-year trendsSecular trendsART initiatorsCohort studyHazard ratioMedian timeFill dateMedicaid claimsMedicaid beneficiariesAdjusted model
2016
Religion, Spirituality, and HIV Clinical Outcomes: A Systematic Review of the Literature
Doolittle BR, Justice AC, Fiellin DA. Religion, Spirituality, and HIV Clinical Outcomes: A Systematic Review of the Literature. AIDS And Behavior 2016, 22: 1792-1801. PMID: 28004218, DOI: 10.1007/s10461-016-1651-z.Peer-Reviewed Original ResearchConceptsHIV clinical outcomesClinical outcomesSystematic reviewFurther longitudinal studiesEnglish-language articlesPositive associationHIV outcomesInclusion criteriaPatient careLanguage articlesOutcomesLongitudinal studyRelevant databasesAssociationSystematic literature reviewNegative associationReviewLiterature reviewHIVPatientsStudyCare
2015
Adherence and HIV RNA Suppression in the Current Era of Highly Active Antiretroviral Therapy
Viswanathan S, Justice AC, Alexander GC, Brown TT, Gandhi NR, McNicholl IR, Rimland D, Rodriguez-Barradas MC, Jacobson LP. Adherence and HIV RNA Suppression in the Current Era of Highly Active Antiretroviral Therapy. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2015, 69: 493-498. PMID: 25886923, PMCID: PMC4482798, DOI: 10.1097/qai.0000000000000643.Peer-Reviewed Original ResearchConceptsHIV RNA suppressionOdds of suppressionActive antiretroviral therapyRNA suppressionHAART regimenAntiretroviral therapyVeterans Aging Cohort Study Virtual CohortHighly Active Antiretroviral TherapyFirst HAART regimenProtease inhibitor usersRepeated-measures logistic regressionVeterans' Affairs pharmacyViral load suppressionHAART usersNew HAARTRegimen typeInhibitor usersHIV infectionNonnucleoside reverseLow adherenceAdherence levelsPerfect adherenceVirtual cohortLogistic regressionDuration of timeNumber of Drinks to “Feel a Buzz” by HIV Status and Viral Load in Men
McGinnis KA, Fiellin DA, Tate JP, Cook RL, Braithwaite RS, Bryant KJ, Edelman EJ, Gordon AJ, Kraemer KL, Maisto SA, Justice AC, The Veterans Aging Cohort Study. Number of Drinks to “Feel a Buzz” by HIV Status and Viral Load in Men. AIDS And Behavior 2015, 20: 504-511. PMID: 26936030, PMCID: PMC4780364, DOI: 10.1007/s10461-015-1053-7.Peer-Reviewed Original ResearchConceptsUninfected menNumber of drinksViral load suppressionMean numberImpact of HIVBlood alcohol concentrationEffects of alcoholAntiretroviral initiationDetectable VLCohort studyVL suppressionHIV statusMultivariable analysisViral loadLower mean numberHIVCurrent drinkingMenDrinksAlcohol concentrationSuppressionIncarceration and health outcomes in HIV‐infected patients: The impact of substance use, primary care engagement, and antiretroviral adherence
Wang EA, McGinnis KA, Long JB, Akgün KM, Edelman EJ, Rimland D, Wang KH, Justice AC, Fiellin DA. Incarceration and health outcomes in HIV‐infected patients: The impact of substance use, primary care engagement, and antiretroviral adherence. American Journal On Addictions 2015, 24: 178-184. PMID: 25662297, PMCID: PMC4397180, DOI: 10.1111/ajad.12177.Peer-Reviewed Original ResearchConceptsVeterans Aging Cohort StudyHistory of incarcerationHIV disease outcomeVACS Index scorePrimary care engagementAntiretroviral adherenceCare engagementDisease outcomeIndex scoreDrug useHigher VACS Index scoresHealth of HIVAging Cohort StudyUnhealthy alcohol useViral RNA loadRecent drug useLow CD4Cohort studyRNA loadDrug treatmentHIVHealth outcomesMultivariate analysisMediation analysisPatients
2014
Hepatic decompensation in antiretroviral-treated patients co-infected with HIV and hepatitis C virus compared with hepatitis C virus-monoinfected patients: a cohort study.
Lo Re V, Kallan MJ, Tate JP, Localio AR, Lim JK, Goetz MB, Klein MB, Rimland D, Rodriguez-Barradas MC, Butt AA, Gibert CL, Brown ST, Park L, Dubrow R, Reddy KR, Kostman JR, Strom BL, Justice AC. Hepatic decompensation in antiretroviral-treated patients co-infected with HIV and hepatitis C virus compared with hepatitis C virus-monoinfected patients: a cohort study. Annals Of Internal Medicine 2014, 160: 369-79. PMID: 24723077, PMCID: PMC4254786, DOI: 10.7326/m13-1829.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-Retroviral AgentsAscitesBacterial InfectionsCarcinoma, HepatocellularCoinfectionEsophageal and Gastric VaricesFemaleGastrointestinal HemorrhageHepatitis C, ChronicHIVHIV InfectionsHumansIncidenceLiver NeoplasmsMaleMedication AdherenceMiddle AgedPeritonitisRetrospective StudiesRNA, ViralTreatment OutcomeViral LoadConceptsCo-infected patientsHepatitis C virusHepatic decompensationAntiretroviral-treated patientsCohort studyNonblack raceC virusHepatitis C virus-monoinfected patientsChronic hepatitis C virusHigh rateAntiretroviral therapy eraDetectable HCV RNAIncident hepatic decompensationBaseline hemoglobin levelRetrospective cohort studySpontaneous bacterial peritonitisAdvanced hepatic fibrosisAdvanced liver fibrosisVeterans Health AdministrationDiagnosis of ascitesRate of decompensationTherapy eraHIV RNAVariceal hemorrhageHCV RNA
2013
A Study of Financial Incentives to Reduce Plasma HIV RNA Among Patients in Care
Farber S, Tate J, Frank C, Ardito D, Kozal M, Justice AC, Scott Braithwaite R. A Study of Financial Incentives to Reduce Plasma HIV RNA Among Patients in Care. AIDS And Behavior 2013, 17: 2293-2300. PMID: 23404097, PMCID: PMC3742414, DOI: 10.1007/s10461-013-0416-1.Peer-Reviewed Original ResearchConceptsViral load suppressionFeasibility outcomesPatient acceptabilityPatient comprehensionPlasma HIV RNADetectable viral loadViral load testsSingle-site studyEligible patientsHIV careHIV RNAART adherenceViral loadHIV transmissionOwn controlPatientsPatient workflowFinancial incentivesOutcomesCareDownstream costsIncentive sizeBiological outcomesAcceptabilityClinicPersonal Health Record Use and Its Association with Antiretroviral Adherence: Survey and Medical Record Data from 1871 US Veterans Infected with HIV
Keith McInnes D, Shimada SL, Rao SR, Quill A, Duggal M, Gifford AL, Brandt CA, Houston TK, Ohl ME, Gordon KS, Mattocks KM, Kazis LE, Justice AC. Personal Health Record Use and Its Association with Antiretroviral Adherence: Survey and Medical Record Data from 1871 US Veterans Infected with HIV. AIDS And Behavior 2013, 17: 3091-3100. PMID: 23334359, DOI: 10.1007/s10461-012-0399-3.Peer-Reviewed Original ResearchConceptsPersonal health record useMedical record dataPHR useAntiretroviral adherenceElectronic personal health record useVeterans Aging Cohort StudyRecord useHIV care processesMedication possession ratioAging Cohort StudyPharmacy refill dataRecord dataImproved patient outcomesCross-sectional surveyCohort studyPossession ratioDepression careRefill dataMedication adherenceUS veteransPatient outcomesAdherence measuresCare processesSocio-demographic variablesAdherence
2012
Antiretroviral Adherence Among Rural Compared to Urban Veterans with HIV Infection in the United States
Ohl ME, Perencevich E, McInnes DK, Kim N, Rimland D, Akgun K, Fiellin DA, Skanderson M, Wang K, Justice A. Antiretroviral Adherence Among Rural Compared to Urban Veterans with HIV Infection in the United States. AIDS And Behavior 2012, 17: 174-180. PMID: 23080359, DOI: 10.1007/s10461-012-0325-8.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-Retroviral AgentsConfidence IntervalsFemaleFollow-Up StudiesHIV InfectionsHumansLogistic ModelsMaleMedication AdherenceMiddle AgedOdds RatioResidence CharacteristicsRetrospective StudiesRural PopulationSocioeconomic FactorsUnited StatesUnited States Department of Veterans AffairsUrban PopulationVeteransConceptsRural-dwelling personsAntiretroviral therapyAntiretroviral adherenceUrban veteransRural-Urban Commuting Area codesVeterans Affairs Healthcare SystemCombination antiretroviral therapyHepatitis C infectionMultivariable logistic regressionSubstance use disordersC infectionHIV infectionRemote residentsHigh adherenceWhite raceVA healthcareUse disordersMedian proportionLogistic regressionAdherenceHealthcare systemRemote settingsTherapyInfectionFace barriers
2011
Food Insecurity is Associated with Poor Virologic Response among HIV-Infected Patients Receiving Antiretroviral Medications
Wang EA, McGinnis KA, Fiellin DA, Goulet JL, Bryant K, Gibert CL, Leaf DA, Mattocks K, Sullivan LE, Vogenthaler N, Justice AC, for the VACS Project Team. Food Insecurity is Associated with Poor Virologic Response among HIV-Infected Patients Receiving Antiretroviral Medications. Journal Of General Internal Medicine 2011, 26: 1012-1018. PMID: 21573882, PMCID: PMC3157515, DOI: 10.1007/s11606-011-1723-8.Peer-Reviewed Original ResearchConceptsHIV-1 RNAHIV disease outcomeLow CD4 countAntiretroviral medicationsBody mass indexCD4 countMass indexDisease outcomeVeterans Aging Cohort StudyPoor virologic responseUnsuppressed viral loadAging Cohort StudyMultivariable logistic regressionAntiretroviral medication adherenceCross-sectional studyFood insecure participantsFood-secure participantsPotential causal associationVirologic responseVirologic suppressionCohort studyHIV diseaseHIV outcomesAdjusted analysisFood insecurity
2010
Evaluating Interventions to Improve Antiretroviral Adherence: How Much of an Effect Is Required for Favorable Value?
Braithwaite RS, Fiellin DA, Nucifora K, Bryant K, Roberts M, Kim N, Justice AC. Evaluating Interventions to Improve Antiretroviral Adherence: How Much of an Effect Is Required for Favorable Value? Value In Health 2010, 13: 535-542. PMID: 20345544, PMCID: PMC3032536, DOI: 10.1111/j.1524-4733.2010.00714.x.Peer-Reviewed Original ResearchConceptsAbsolute risk reductionNonadherent patientsAdherence interventionsRelative riskRisk factorsAntiretroviral therapy adherence interventionsEffect sizeNonadherence risk factorsBehavioral risk factorsHIV careAntiretroviral adherencePatientsNonadherenceSocietal perspectiveIncremental costIntervention costsSmall effect sizesLife expectancyInterventionRisk reductionPlausible effect sizes
2009
Hepatitis C treatment completion rates in routine clinical care
Butt AA, McGinnis KA, Skanderson M, Justice AC. Hepatitis C treatment completion rates in routine clinical care. Liver International 2009, 30: 240-250. PMID: 19889081, PMCID: PMC3132089, DOI: 10.1111/j.1478-3231.2009.02156.x.Peer-Reviewed Original ResearchConceptsPre-treatment anemiaTreatment completion ratesVA National Patient Care DatabaseHuman immunodeficiency virus (HIV) coinfectionNational Patient Care DatabasePharmacy Benefits Management databaseHepatitis C virus infectionCompletion ratesHigher comorbidity countC virus infectionImmunodeficiency virus coinfectionCoronary artery diseasePatient Care DatabaseRoutine clinical careClinical practice settingTreatment sitesInitiate therapyInterferon useComorbidity countPharmacy recordsStandard interferonArtery diseaseVirus coinfectionMultivariable analysisCare databaseDo Benefits of Earlier Antiretroviral Treatment Initiation Outweigh Harms for Individuals at Risk for Poor Adherence?
Braithwaite RS, Roberts MS, Goetz MB, Gibert CL, Rodriguez-Barradas MC, Nucifora K, Justice AC. Do Benefits of Earlier Antiretroviral Treatment Initiation Outweigh Harms for Individuals at Risk for Poor Adherence? Clinical Infectious Diseases 2009, 48: 822-826. PMID: 19210173, PMCID: PMC3032571, DOI: 10.1086/596768.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntiviral AgentsComputer SimulationHIV InfectionsHumansLife ExpectancyMedication AdherenceMiddle AgedTime FactorsTreatment Outcome
2008
Adjusting Alcohol Quantity for Mean Consumption and Intoxication Threshold Improves Prediction of Nonadherence in HIV Patients and HIV‐Negative Controls
Braithwaite RS, Conigliaro J, McGinnis KA, Maisto SA, Bryant K, Justice AC. Adjusting Alcohol Quantity for Mean Consumption and Intoxication Threshold Improves Prediction of Nonadherence in HIV Patients and HIV‐Negative Controls. Alcohol Clinical And Experimental Research 2008, 32: 1645-1651. PMID: 18616666, PMCID: PMC3111093, DOI: 10.1111/j.1530-0277.2008.00732.x.Peer-Reviewed Original ResearchConceptsMean daily alcohol consumptionProportion of daysDaily alcohol consumptionSignificant nonadherenceAlcohol consumptionCohort studyTimeline FollowbackVeterans Aging Cohort StudyMedication adherence historyMulti-site cohort studyHIV-negative controlsAging Cohort StudyAlcohol-induced cognitive impairmentCross-sectional analysisNonadherence riskHIV patientsUninfected patientsMedication dosesMedication nonadherencePrescribed medicationsAdherence historyNonadherenceUninfected controlsUsual levelStandard drinks