2022
Soluble CD14-associated DNA methylation sites predict mortality among men with HIV infection
Titanji BK, Wang Z, Chen J, Hui Q, So-Armah K, Freiberg M, Justice AC, Ke X, Marconi VC, Sun YV. Soluble CD14-associated DNA methylation sites predict mortality among men with HIV infection. AIDS 2022, 36: 1563-1571. PMID: 35979830, PMCID: PMC9394925, DOI: 10.1097/qad.0000000000003279.Peer-Reviewed Original ResearchConceptsVeterans Aging Cohort StudyAging Cohort StudyElevated plasma levelsCox regression modelUnderstanding of prognosisPeripheral blood samplesPotential therapeutic targetEpigenome-wide association studiesMultiple testingCause mortalitySCD14 levelsCohort studyHIV infectionPlasma levelsSoluble CD14Disease progressionImmune functionSurvival timeBlood samplesSCD14Therapeutic targetPWHAntiviral responseSignificant associationDNAm sites
2017
HIV and Obesity Comorbidity Increase Interleukin 6 but Not Soluble CD14 or D-Dimer
Taylor BS, So-Armah K, Tate JP, Marconi VC, Koethe JR, Bedimo RJ, Butt AA, Gibert CL, Goetz MB, Rodriguez-Barradas MC, Womack JA, Gerschenson M, Lo Re V, Rimland D, Yin MT, Leaf D, Tracy RP, Justice AC, Freiberg MS. HIV and Obesity Comorbidity Increase Interleukin 6 but Not Soluble CD14 or D-Dimer. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2017, 75: 500-508. PMID: 28696344, PMCID: PMC5513170, DOI: 10.1097/qai.0000000000001444.Peer-Reviewed Original ResearchConceptsIL-6Nonobese/Obese/D-dimerMedian IL-6 levelHIV status groupsElevated IL-6D-dimer levelsIL-6 levelsBody mass indexLogistic regression modelsElevated sCD14Uninfected participantsSCD14 levelsHIV infectionProinflammatory stateHIV statusInflammation increasesMass indexObesity/Soluble CD14Interleukin-6Obesity prevalenceOdds ratioInclusion criteria