2023
Identifying genetic loci and phenomic associations of substance use traits: A multi‐trait analysis of GWAS (MTAG) study
Xu H, Toikumo S, Crist R, Glogowska K, Jinwala Z, Deak J, Justice A, Gelernter J, Johnson E, Kranzler H, Kember R. Identifying genetic loci and phenomic associations of substance use traits: A multi‐trait analysis of GWAS (MTAG) study. Addiction 2023, 118: 1942-1952. PMID: 37156939, PMCID: PMC10754226, DOI: 10.1111/add.16229.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesSignificant single nucleotide polymorphismsSubstance use traitsMulti-trait analysisAssociation studiesGenetic architectureUse traitsGenome-wide significant single nucleotide polymorphismsProtein-protein interaction analysisTrait genetic architectureNumber of lociPolygenic risk scoresEuropean ancestry individualsNovel lociSingle nucleotide polymorphismsGenetic lociGWAS studiesLociMultiple related phenotypesNucleotide polymorphismsRelated phenotypesTraitsNovel associationsMTAgBiobank samples
2011
A polymorphism in the leptin gene promoter is associated with anemia in patients with HIV disease
Vanasse GJ, Jeong JY, Tate J, Bathulapalli H, Anderson D, Steen H, Fleming M, Mattocks K, Telenti A, Fellay J, Justice AC, Berliner N. A polymorphism in the leptin gene promoter is associated with anemia in patients with HIV disease. Blood 2011, 118: 5401-5408. PMID: 21926355, PMCID: PMC3217345, DOI: 10.1182/blood-2011-06-362194.Peer-Reviewed Original ResearchConceptsVeterans Aging Cohort StudyCombined antiretroviral therapyPrevalence of anemiaHIV diseaseSingle nucleotide polymorphismsModern combined antiretroviral therapyWorld Health Organization criteriaAging Cohort StudyA Single Nucleotide PolymorphismGene single nucleotide polymorphismsLeptin gene promoterHIV subjectsAntiretroviral therapyCohort studyHIV statusOrganization criteriaClinical dataIndependent cohortAnemiaHIVPatientsLeptin genePrevalenceDiseaseCandidate gene approach
2006
The Role of Macrophage Migration Inhibitory Factor (MIF) Genetic Polymorphisms in Predicting the Development of Macrocytic Anemia in HIV+ Patients.
Lin S, Fultz S, Justice A, Bucala R, Vanasse K, Berliner N. The Role of Macrophage Migration Inhibitory Factor (MIF) Genetic Polymorphisms in Predicting the Development of Macrocytic Anemia in HIV+ Patients. Blood 2006, 108: 1254. DOI: 10.1182/blood.v108.11.1254.1254.Peer-Reviewed Original ResearchDevelopment of anemiaVeterans Aging Cohort StudySetting of HIVMIF expressionMIF polymorphismsMacrocytic anemiaCox proportional hazards modelMacrophage migration inhibitory factor geneMarkers of morbidityMIF gene polymorphismsEtiology of anemiaIndependent risk factorCo-morbid conditionsCo-morbid diseasesAging Cohort StudySingle nucleotide polymorphismsSeverity of manifestationsRelease of TNFProportional hazards modelCytokine gene expressionMean corpuscular volumeType/severityVariety of illnessesCD4 countCohort study