2020
DNA methylation mediates the effect of cocaine use on HIV severity
Shu C, Justice AC, Zhang X, Wang Z, Hancock DB, Johnson EO, Xu K. DNA methylation mediates the effect of cocaine use on HIV severity. Clinical Epigenetics 2020, 12: 140. PMID: 32928285, PMCID: PMC7491141, DOI: 10.1186/s13148-020-00934-1.Peer-Reviewed Original ResearchConceptsHIV-positive participantsHIV severityVACS IndexCocaine useCocaine effectsVeterans Aging Cohort Study Biomarker CohortVeterans Aging Cohort Study (VACS) IndexEpigenome-wide associationHuman immunodeficiency virus (HIV) progressionHigher VACS indexFrequent cocaine useCandidate CpG sitesPersistent cocaine useMendelian randomization analysisHIV outcomesBiomarker cohortHIV progressionVirus progressionVAC indexVeteran populationAntiviral responseCandidate mediatorsStudy indicesMR analysisSeverityThe Veterans Aging Cohort Study (VACS) Index Predicts Mortality in a Community-recruited Cohort of People With Human Immunodeficiency Virus (HIV) Who Use Illicit Drugs
Reddon H, Grant C, Nosova E, Fairbairn N, Barrios R, Justice AC, Nolan S, Socias ME, Milloy MJ. The Veterans Aging Cohort Study (VACS) Index Predicts Mortality in a Community-recruited Cohort of People With Human Immunodeficiency Virus (HIV) Who Use Illicit Drugs. Clinical Infectious Diseases 2020, 73: 538-541. PMID: 32857842, PMCID: PMC8496478, DOI: 10.1093/cid/ciaa1263.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusVeterans Aging Cohort Study (VACS) IndexHuman immunodeficiency virus (HIV) disease severityStudy indicesCommunity-recruited cohortIllicit drugsVirus disease severityVACS IndexProspective cohortImmunodeficiency virusClinical biomarkersDisease severityStudy periodCohortMortalityDrugsIndexBiomarkersSeverity
2019
HIV Disease Severity Is Sensitive to Temporal Changes in Alcohol Use: A National Study of VA Patients With HIV.
Williams EC, McGinnis KA, Tate JP, Matson TE, Rubinsky AD, Bobb JF, Lapham GT, Edelman EJ, Catz SL, Satre DD, Bryant KJ, Marshall BDL, Kraemer KL, Bensley KM, Richards JE, Skanderson M, Justice AC, Fiellin DA, Bradley KA. HIV Disease Severity Is Sensitive to Temporal Changes in Alcohol Use: A National Study of VA Patients With HIV. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2019, 81: 448-455. PMID: 30973541, PMCID: PMC6594884, DOI: 10.1097/qai.0000000000002049.Peer-Reviewed Original ResearchConceptsVACS Index 2.0HIV disease severityVeterans Aging Cohort StudyAlcohol useDisease severityLow-level alcohol useNational Veterans Health AdministrationChange scoresAging Cohort StudyVeterans Health AdministrationAUDIT-C screensAUDIT-CsCohort studyHIV severityVA patientsHealth AdministrationSeverity measuresSeverityHIVPWHMultiple mechanismsNational studyScoresNational sampleDays
2018
Changes in alcohol use associated with changes in HIV disease severity over time: A national longitudinal study in the Veterans Aging Cohort
Williams EC, McGinnis KA, Bobb JF, Rubinsky AD, Lapham GT, Skanderson M, Catz SL, Bensley KM, Richards JE, Bryant KJ, Edelman EJ, Satre DD, Marshall BDL, Kraemer KL, Blosnich JR, Crystal S, Gordon AJ, Fiellin DA, Justice AC, Bradley KA. Changes in alcohol use associated with changes in HIV disease severity over time: A national longitudinal study in the Veterans Aging Cohort. Drug And Alcohol Dependence 2018, 189: 21-29. PMID: 29859388, PMCID: PMC6344121, DOI: 10.1016/j.drugalcdep.2018.04.022.Peer-Reviewed Original ResearchConceptsHIV severityAUDIT-C screensViral loadAlcohol useVeterans Aging Cohort Study (VACS) dataPoor HIV controlVeterans Aging CohortHIV disease severityAUDIT-C scoresCohort study dataLow-level drinkingStable drinkingVL analysisHIV controlMean changeAging CohortDisease severityPLWHGreater riskCD4Individual alcohol useSeverityDrinking trajectoriesNational Longitudinal StudyLongitudinal study
2004
The Veterans Aging Cohort Study: Observational Studies of Alcohol Use, Abuse, and Outcomes Among Human Immunodeficiency Virus–Infected Veterans
Conigliaro J, Madenwald T, Bryant K, Braithwaite S, Gordon A, Fultz SL, Maisto S, Samet J, Kraemer K, Cook R, Day N, Roach D, Richey S, Justice A. The Veterans Aging Cohort Study: Observational Studies of Alcohol Use, Abuse, and Outcomes Among Human Immunodeficiency Virus–Infected Veterans. Alcohol Clinical And Experimental Research 2004, 28: 313-321. PMID: 15112939, DOI: 10.1097/01.alc.0000113414.73220.21.Peer-Reviewed Original Research
1998
Associations Between the Use of Do-Not-Resuscitate Orders and Length of Stay in Patients With Stroke
Shepardson L, Justice A, Harper D, Rosenthal G. Associations Between the Use of Do-Not-Resuscitate Orders and Length of Stay in Patients With Stroke. Medical Care 1998, 36: as57-as67. PMID: 9708583, DOI: 10.1097/00005650-199808001-00007.Peer-Reviewed Original ResearchConceptsAnalysis of patientsAdmission severityDNR ordersResuscitate ordersHospital mortalityMedical recordsDay 1Day 8Retrospective cohort analysisCox regression analysisLength of stayAcute care hospitalsPatients' medical recordsHospital stayCare hospitalConsecutive patientsPrimary diagnosisHospital careCohort analysisPatientsDay 3Standardized reviewIllnessSeverityLOS