2022
Validation of a multi-ancestry polygenic risk score and age-specific risks of prostate cancer: A meta-analysis within diverse populations
Chen F, Darst BF, Madduri RK, Rodriguez AA, Sheng X, Rentsch CT, Andrews C, Tang W, Kibel AS, Plym A, Cho K, Jalloh M, Gueye SM, Niang L, Ogunbiyi OJ, Popoola O, Adebiyi AO, Aisuodionoe-Shadrach OI, Ajibola HO, Jamda MA, Oluwole OP, Nwegbu M, Adusei B, Mante S, Darkwa-Abrahams A, Mensah JE, Adjei AA, Diop H, Lachance J, Rebbeck TR, Ambs S, Gaziano JM, Justice AC, Conti DV, Haiman CA. Validation of a multi-ancestry polygenic risk score and age-specific risks of prostate cancer: A meta-analysis within diverse populations. ELife 2022, 11: e78304. PMID: 35801699, PMCID: PMC9322982, DOI: 10.7554/elife.78304.Peer-Reviewed Original ResearchConceptsProstate cancer riskPolygenic risk scoresProstate cancerCancer riskOdds ratioMillion Veteran ProgramRisk scoreRisk stratification toolAge-specific absolute risksAfrican ancestry menCancer odds ratiosVeterans Health AdministrationCase-control studyNonaggressive prostate cancerProstate Cancer FoundationAge-specific riskAssociation of PRSPRS categoriesRisk-stratified screeningVeteran ProgramNational Cancer InstituteEuropean ancestry menStratification toolAbsolute riskEffect modificationGeographic and temporal variation in racial and ethnic disparities in SARS-CoV-2 positivity between February 2020 and August 2021 in the United States
Ferguson JM, Justice AC, Osborne TF, Magid HSA, Purnell AL, Rentsch CT. Geographic and temporal variation in racial and ethnic disparities in SARS-CoV-2 positivity between February 2020 and August 2021 in the United States. Scientific Reports 2022, 12: 273. PMID: 34997001, PMCID: PMC8741774, DOI: 10.1038/s41598-021-03967-5.Peer-Reviewed Original Research
2021
The relationship of smoking and unhealthy alcohol use to the HIV care continuum among people with HIV in an integrated health care system
Satre DD, Levine-Hall T, Sterling SA, Young-Wolff KC, Lam JO, Alexeeff S, Hojilla JC, Williams A, Justice AC, Sterne J, Cavassini M, Bryant KJ, Williams EC, Horberg MA, Volberding P, Weisner C, Silverberg MJ. The relationship of smoking and unhealthy alcohol use to the HIV care continuum among people with HIV in an integrated health care system. Drug And Alcohol Dependence 2021, 219: 108481. PMID: 33429295, PMCID: PMC7869693, DOI: 10.1016/j.drugalcdep.2020.108481.Peer-Reviewed Original ResearchConceptsUnhealthy alcohol useHIV care continuum outcomesIntegrated health care systemCare continuum outcomesAlcohol useHealth care systemContinuum outcomesCare continuumOdds ratioHigher oddsKaiser Permanente Northern CaliforniaCare systemHIV RNA controlPrimary care screeningHIV care continuumRelationship of smokingAdjusted odds ratioSeparate logistic regression modelsLogistic regression modelsRace/ethnicityHIV careHIV RNASmoking statusMean ageCare screening
2020
Does Reducing Drinking in Patients with Unhealthy Alcohol Use Improve Pain Interference, Use of Other Substances, and Psychiatric Symptoms?
Caniglia EC, Stevens ER, Khan M, Young KE, Ban K, Marshall BDL, Chichetto NE, Gaither JR, Crystal S, Edelman EJ, Fiellin DA, Gordon AJ, Bryant KJ, Tate J, Justice AC, Braithwaite RS. Does Reducing Drinking in Patients with Unhealthy Alcohol Use Improve Pain Interference, Use of Other Substances, and Psychiatric Symptoms? Alcohol Clinical And Experimental Research 2020, 44: 2257-2265. PMID: 33030753, PMCID: PMC8077101, DOI: 10.1111/acer.14455.Peer-Reviewed Original ResearchConceptsUnhealthy alcohol useAlcohol usePain interferenceTobacco smokingUS veteransOdds ratioPsychiatric symptomsDepressive symptomsCocaine useVeterans Aging Cohort StudyAlcohol Use Disorders Identification Test (AUDIT) questionnaireCannabis useSubstance useAging Cohort StudyAnxiety symptomsSeparate logistic regression modelsChronic pain interferenceMultisite observational studyLogistic regression modelsCohort studyInverse probability weightingNext followObservational studyPotential selection biasYears postbaselineAre we missing opioid-related deaths among people with HIV?
Becker WC, Gordon KS, Edelman EJ, Goulet JL, Kerns RD, Marshall BDL, Fiellin DA, Justice AC, Tate JP. Are we missing opioid-related deaths among people with HIV? Drug And Alcohol Dependence 2020, 212: 108003. PMID: 32417360, PMCID: PMC9580216, DOI: 10.1016/j.drugalcdep.2020.108003.Peer-Reviewed Original ResearchConceptsVeterans Aging Cohort StudyOpioid useOverdose deathsLife-limiting conditionsUnnatural deathsGreater oddsAging Cohort StudyVACS IndexOpioid exposureCohort studyHIV infectionHIV statusRisk factorsOdds ratioDeath filesIndex causeHIVDisease severityDeathDecedentsIllicit useDifferential misclassificationOddsCauseOpioidsInsights Provided by Depression Screening Regarding Pain, Anxiety, and Substance use in a Veteran Population
Stevens ER, Mazumdar M, Caniglia EC, Khan MR, Young KE, Edelman EJ, Gordon AJ, Fiellin DA, Maisto SA, Chichetto NE, Crystal S, Gaither JR, Justice AC, Braithwaite RS. Insights Provided by Depression Screening Regarding Pain, Anxiety, and Substance use in a Veteran Population. Journal Of Primary Care & Community Health 2020, 11: 2150132720949123. PMID: 32772883, PMCID: PMC7418233, DOI: 10.1177/2150132720949123.Peer-Reviewed Original ResearchConceptsPositive predictive valueSubstance useOdds ratioVeterans Aging Cohort Study (VACS) dataPHQ-9 scoresPrimary care settingCohort study dataTest performance characteristicsSymptoms of anxietyMedian ageDepression screeningLikelihood ratio valuesDepression screenPHQ-9Care settingsVeteran populationPredictive valueSignificant associationSymptomsDiagnostic assessmentAnxietyStudy dataAdditional informationAssociationPain
2019
Regional and Rural-Urban Differences in the Use of Direct-acting Antiviral Agents for Hepatitis C Virus
Njei B, Esserman D, Krishnan S, Ohl M, Tate JP, Hauser RG, Taddei T, Lim J, Justice AC. Regional and Rural-Urban Differences in the Use of Direct-acting Antiviral Agents for Hepatitis C Virus. Medical Care 2019, 57: 279-285. PMID: 30807449, PMCID: PMC6436819, DOI: 10.1097/mlr.0000000000001071.Peer-Reviewed Original ResearchConceptsDirect-acting antiviral agentsHepatitis C virus infectionVeterans Affairs Healthcare SystemRural-Urban Commuting Area codesCurative HCV treatmentRural-urban designationC virus infectionElectronic health record dataHepatitis C virusPrior treatment experienceLower odds ratioHealth record dataZone improvement plan codeEligible patientsHCV treatmentAntiretroviral medicationsRural-urban residenceLiver diseaseUnadjusted analysesC virusRural-urban differencesOdds ratioMultivariable modelLower incidenceObservational study
2017
HIV and Obesity Comorbidity Increase Interleukin 6 but Not Soluble CD14 or D-Dimer
Taylor BS, So-Armah K, Tate JP, Marconi VC, Koethe JR, Bedimo RJ, Butt AA, Gibert CL, Goetz MB, Rodriguez-Barradas MC, Womack JA, Gerschenson M, Lo Re V, Rimland D, Yin MT, Leaf D, Tracy RP, Justice AC, Freiberg MS. HIV and Obesity Comorbidity Increase Interleukin 6 but Not Soluble CD14 or D-Dimer. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2017, 75: 500-508. PMID: 28696344, PMCID: PMC5513170, DOI: 10.1097/qai.0000000000001444.Peer-Reviewed Original ResearchConceptsIL-6Nonobese/Obese/D-dimerMedian IL-6 levelHIV status groupsElevated IL-6D-dimer levelsIL-6 levelsBody mass indexLogistic regression modelsElevated sCD14Uninfected participantsSCD14 levelsHIV infectionProinflammatory stateHIV statusInflammation increasesMass indexObesity/Soluble CD14Interleukin-6Obesity prevalenceOdds ratioInclusion criteria
2016
Minority Men Who Have Sex with Men Demonstrate Increased Risk for HIV Transmission
Gordon KS, Edelman EJ, Justice AC, Fiellin DA, Akgün K, Crystal S, Duggal M, Goulet JL, Rimland D, Bryant KJ. Minority Men Who Have Sex with Men Demonstrate Increased Risk for HIV Transmission. AIDS And Behavior 2016, 21: 1497-1510. PMID: 27771818, PMCID: PMC5380471, DOI: 10.1007/s10461-016-1590-8.Peer-Reviewed Original ResearchConceptsDetectable HIV-1 RNAHIV-1 RNAHIV transmissionOdds ratioMSM groupVeterans Aging Cohort StudyMinority MSMAging Cohort StudyMultiple sexual partnersMultiple sex partnersNon-condom useCohort studyInfluence of drugsComparator groupRisk factorsHispanic MSMWhite MSMLow prevalenceHigh incidenceSex partnersSexual partnersMSMSexMinority menGroup
2010
Virologic and immunologic response to HAART, by age and regimen class
Althoff KN, Justice AC, Gange SJ, Deeks SG, Saag MS, Silverberg MJ, Gill MJ, Lau B, Napravnik S, Tedaldi E, Klein MB, Gebo KA. Virologic and immunologic response to HAART, by age and regimen class. AIDS 2010, 24: 2469-2479. PMID: 20829678, PMCID: PMC3136814, DOI: 10.1097/qad.0b013e32833e6d14.Peer-Reviewed Original ResearchConceptsCD4 cell countImmunologic responseNorth American AIDS Cohort CollaborationCell countMean CD4 cell countProtease inhibitor-based regimenNonnucleoside reverse transcriptase inhibitorAntiretroviral-naive adultsInhibitor-based regimenInitial antiretroviral regimenProspective cohort studyConfidence intervalsReverse transcriptase inhibitorImpact of ageInverse probability weightsCohort CollaborationInitial regimenAntiretroviral regimenVirologic responseCohort studyViral loadEligible participantsOdds ratioTranscriptase inhibitorRegimenThe Association Between Alcohol Consumption and Prevalent Cardiovascular Diseases Among HIV-Infected and HIV-Uninfected Men
Freiberg MS, McGinnis KA, Kraemer K, Samet JH, Conigliaro J, Ellison R, Bryant K, Kuller LH, Justice AC. The Association Between Alcohol Consumption and Prevalent Cardiovascular Diseases Among HIV-Infected and HIV-Uninfected Men. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2010, 53: 247-253. PMID: 20009766, PMCID: PMC2858978, DOI: 10.1097/qai.0b013e3181c6c4b7.Peer-Reviewed Original ResearchConceptsPrevalent cardiovascular diseaseCardiovascular diseaseAlcohol consumptionHigh prevalenceAlcohol abuseHazardous drinkingRisk factorsOdds ratioModerate drinkingTraditional CVD risk factorsVeterans Aging Cohort StudyCVD risk factorsTraditional risk factorsAging Cohort StudyHIV-uninfected (HIV-) menHIV-InfectedSimilar HIVAntiretroviral therapyCD4 countCohort studyProspective cohortPast drinkersKidney diseaseHIVLogistic regression
2009
HIV infection and the risk of diabetes mellitus
Butt AA, McGinnis K, Rodriguez-Barradas MC, Crystal S, Simberkoff M, Goetz MB, Leaf D, Justice AC. HIV infection and the risk of diabetes mellitus. AIDS 2009, 23: 1227-1234. PMID: 19444074, PMCID: PMC2752953, DOI: 10.1097/qad.0b013e32832bd7af.Peer-Reviewed Original ResearchConceptsRisk of diabetesHCV coinfectionHIV infectionUninfected veteransDiabetes mellitusRisk factorsVeterans Aging Cohort StudyMinority raceDiabetes mellitus differsPrevalent diabetes mellitusOdds of diabetesAging Cohort StudyCohort studyInhibitor therapyHIV statusUninfected personsLower BMIMale sexBaseline prevalenceARV treatmentOdds ratioHigh riskLow prevalenceHIVLower risk