2021
The relationship of smoking and unhealthy alcohol use to the HIV care continuum among people with HIV in an integrated health care system
Satre DD, Levine-Hall T, Sterling SA, Young-Wolff KC, Lam JO, Alexeeff S, Hojilla JC, Williams A, Justice AC, Sterne J, Cavassini M, Bryant KJ, Williams EC, Horberg MA, Volberding P, Weisner C, Silverberg MJ. The relationship of smoking and unhealthy alcohol use to the HIV care continuum among people with HIV in an integrated health care system. Drug And Alcohol Dependence 2021, 219: 108481. PMID: 33429295, PMCID: PMC7869693, DOI: 10.1016/j.drugalcdep.2020.108481.Peer-Reviewed Original ResearchConceptsUnhealthy alcohol useHIV care continuum outcomesIntegrated health care systemCare continuum outcomesAlcohol useHealth care systemContinuum outcomesCare continuumOdds ratioHigher oddsKaiser Permanente Northern CaliforniaCare systemHIV RNA controlPrimary care screeningHIV care continuumRelationship of smokingAdjusted odds ratioSeparate logistic regression modelsLogistic regression modelsRace/ethnicityHIV careHIV RNASmoking statusMean ageCare screening
2020
Development and validation of a 30-day mortality index based on pre-existing medical administrative data from 13,323 COVID-19 patients: The Veterans Health Administration COVID-19 (VACO) Index
King JT, Yoon JS, Rentsch CT, Tate JP, Park LS, Kidwai-Khan F, Skanderson M, Hauser RG, Jacobson DA, Erdos J, Cho K, Ramoni R, Gagnon DR, Justice AC. Development and validation of a 30-day mortality index based on pre-existing medical administrative data from 13,323 COVID-19 patients: The Veterans Health Administration COVID-19 (VACO) Index. PLOS ONE 2020, 15: e0241825. PMID: 33175863, PMCID: PMC7657526, DOI: 10.1371/journal.pone.0241825.Peer-Reviewed Original ResearchConceptsCharlson Comorbidity IndexVeterans Health AdministrationVACO IndexValidation cohortMedical administrative dataDevelopment cohortSARS-CoV-2 testing resultsMortality indexICD-10 diagnosis codesUS Veterans Health AdministrationSARS-CoV-2 infectionPre-existing medical conditionsCOVID-19 mortality riskPeripheral vascular diseaseCOVID-19 patientsCOVID-19 infectionCOVID-19 mortalitySARS-CoV-2Administrative dataLogistic regression modelsRace/ethnicityCohort subgroupsComorbidity indexOverall mortalityComorbid conditionsDoes Reducing Drinking in Patients with Unhealthy Alcohol Use Improve Pain Interference, Use of Other Substances, and Psychiatric Symptoms?
Caniglia EC, Stevens ER, Khan M, Young KE, Ban K, Marshall BDL, Chichetto NE, Gaither JR, Crystal S, Edelman EJ, Fiellin DA, Gordon AJ, Bryant KJ, Tate J, Justice AC, Braithwaite RS. Does Reducing Drinking in Patients with Unhealthy Alcohol Use Improve Pain Interference, Use of Other Substances, and Psychiatric Symptoms? Alcohol Clinical And Experimental Research 2020, 44: 2257-2265. PMID: 33030753, PMCID: PMC8077101, DOI: 10.1111/acer.14455.Peer-Reviewed Original ResearchConceptsUnhealthy alcohol useAlcohol usePain interferenceTobacco smokingUS veteransOdds ratioPsychiatric symptomsDepressive symptomsCocaine useVeterans Aging Cohort StudyAlcohol Use Disorders Identification Test (AUDIT) questionnaireCannabis useSubstance useAging Cohort StudyAnxiety symptomsSeparate logistic regression modelsChronic pain interferenceMultisite observational studyLogistic regression modelsCohort studyInverse probability weightingNext followObservational studyPotential selection biasYears postbaselineT Lymphocyte Subsets Associated With Prevalent Diabetes in Veterans With and Without Human Immunodeficiency Virus
Bailin SS, McGinnis KA, McDonnell WJ, So-Armah K, Wellons M, Tracy RP, Doyle MF, Mallal S, Justice AC, Freiberg MS, Landay AL, Wanjalla C, Koethe JR. T Lymphocyte Subsets Associated With Prevalent Diabetes in Veterans With and Without Human Immunodeficiency Virus. The Journal Of Infectious Diseases 2020, 222: 252-262. PMID: 32052044, PMCID: PMC7323499, DOI: 10.1093/infdis/jiaa069.Peer-Reviewed Original ResearchConceptsT cell subsetsT cellsMemory CD4Prevalent diabetesMemory T cell expansionVeterans Aging Cohort StudyMultivariable logistic regression modelHuman immunodeficiency virus (HIV) populationPrevalent diabetes casesPrevalent diabetes mellitusChronic immune activationHIV-negative individualsHIV-negative participantsT lymphocyte subsetsPrevalence of diabetesTraditional risk factorsAging Cohort StudyHuman immunodeficiency virusT cell expansionLogistic regression modelsCytomegalovirus serostatusLymphocyte subsetsCohort studyDiabetes mellitusHIV status
2019
343. T-cell Subsets Associated with Diabetes in Veterans with and without HIV
Bailin S, McGinnis K, McDonnell W, So-Armah K, Wellons M, Doyle M, Mallal S, Justice A, Freiberg M, Koethe J. 343. T-cell Subsets Associated with Diabetes in Veterans with and without HIV. Open Forum Infectious Diseases 2019, 6: s182-s183. PMCID: PMC6810455, DOI: 10.1093/ofid/ofz360.416.Peer-Reviewed Original ResearchVeterans Aging Cohort StudyT cell subsetsPrevalent diabetesT cellsHIV statusMemory CD4Immune activationNaïve CD8VA electronic medical recordsMultivariate logistic regression modelAdaptive immune activationAdaptive immune profileT effector memoryChronic immune activationEffector memory cellsAging Cohort StudyCentral memory cellsMemory T cellsBody mass indexICD-9 codesPeripheral mononuclear cellsUnhealthy alcohol useElectronic medical recordsLogistic regression modelsRace/ethnicityDifferentiating Types of Self-Reported Alcohol Abstinence
Gordon KS, McGinnis K, Dao C, Rentsch CT, Small A, Smith RV, Kember RL, Gelernter J, Kranzler HR, Bryant KJ, Tate JP, Justice AC. Differentiating Types of Self-Reported Alcohol Abstinence. AIDS And Behavior 2019, 24: 655-665. PMID: 31435887, PMCID: PMC6994373, DOI: 10.1007/s10461-019-02638-x.Peer-Reviewed Original ResearchConceptsLifetime abstainersSelf-reported alcohol abstinenceAlcohol biomarkersGenetic polymorphismsLogistic regression modelsHepatitis CAlcohol abstinenceUninfected individualsCharacteristics of peopleAlcohol useAbstinenceHealth effectsSmokingAbstainersBiomarkersRegression modelsOddsAssociationPLWHPolymorphismHIVCocaine
2017
HIV and Obesity Comorbidity Increase Interleukin 6 but Not Soluble CD14 or D-Dimer
Taylor BS, So-Armah K, Tate JP, Marconi VC, Koethe JR, Bedimo RJ, Butt AA, Gibert CL, Goetz MB, Rodriguez-Barradas MC, Womack JA, Gerschenson M, Lo Re V, Rimland D, Yin MT, Leaf D, Tracy RP, Justice AC, Freiberg MS. HIV and Obesity Comorbidity Increase Interleukin 6 but Not Soluble CD14 or D-Dimer. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2017, 75: 500-508. PMID: 28696344, PMCID: PMC5513170, DOI: 10.1097/qai.0000000000001444.Peer-Reviewed Original ResearchConceptsIL-6Nonobese/Obese/D-dimerMedian IL-6 levelHIV status groupsElevated IL-6D-dimer levelsIL-6 levelsBody mass indexLogistic regression modelsElevated sCD14Uninfected participantsSCD14 levelsHIV infectionProinflammatory stateHIV statusInflammation increasesMass indexObesity/Soluble CD14Interleukin-6Obesity prevalenceOdds ratioInclusion criteria
2016
Incarceration History and Uncontrolled Blood Pressure in a Multi-Site Cohort
Howell BA, Long JB, Edelman EJ, McGinnis KA, Rimland D, Fiellin DA, Justice AC, Wang EA. Incarceration History and Uncontrolled Blood Pressure in a Multi-Site Cohort. Journal Of General Internal Medicine 2016, 31: 1496-1502. PMID: 27619934, PMCID: PMC5130961, DOI: 10.1007/s11606-016-3857-1.Peer-Reviewed Original ResearchConceptsVeterans Aging Cohort StudyRecent incarcerationPost-traumatic stress disorderBP controlPast historyUncontrolled blood pressureBlood pressure controlHistory of hypertensionAging Cohort StudyCardiovascular disease mortalityRisk of hypertensionPrimary care engagementHistory of incarcerationLogistic regression modelsConclusionsAmong patientsUncontrolled BPAntihypertensive medicationsCohort studyBlood pressureClinical factorsHypertension outcomesMultivariable analysisCare engagementDisease mortalityInclusion criteria
2014
Increased Risk of Radiographic Emphysema in HIV Is Associated With Elevated Soluble CD14 and Nadir CD4
Attia EF, Akgün KM, Wongtrakool C, Goetz MB, Rodriguez-Barradas MC, Rimland D, Brown ST, Hoo G, Kim J, Lee PJ, Schnapp LM, Sharafkhaneh A, Justice AC, Crothers K. Increased Risk of Radiographic Emphysema in HIV Is Associated With Elevated Soluble CD14 and Nadir CD4. CHEST Journal 2014, 146: 1543-1553. PMID: 25080158, PMCID: PMC4251616, DOI: 10.1378/chest.14-0543.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsBiomarkersCD4 AntigensComorbidityConfidence IntervalsCross-Sectional StudiesFemaleHIV InfectionsHumansLipopolysaccharide ReceptorsLogistic ModelsMaleMiddle AgedMultivariate AnalysisOdds RatioPrognosisPulmonary EmphysemaRadiographyReference ValuesRisk AssessmentSensitivity and SpecificitySeverity of Illness IndexSex FactorsStatistics, NonparametricConceptsIndependent risk factorSoluble CD14 levelsHIV infectionRadiographic emphysemaEmphysema severityCD14 levelsRisk factorsHIV-Associated Lung Emphysema (EXHALE) studyHigher soluble CD14 levelsNadir CD4 cell countMultivariable logistic regression modelElevated soluble CD14CD4 cell countCells/μLLower lung zonesRisk of HIVCross-sectional analysisLogistic regression modelsNadir CD4HIV RNALung involvementHIV severityD-dimerDiffuse involvementMultivariable analysis
2013
Hazardous drinking and its association with homelessness among veterans in care
Ghose T, Fiellin DA, Gordon AJ, Metraux S, Goetz MB, Blackstock O, McInnes K, Rodriguez-Barradas MC, Justice AC. Hazardous drinking and its association with homelessness among veterans in care. Drug And Alcohol Dependence 2013, 132: 202-206. PMID: 23474200, PMCID: PMC8101641, DOI: 10.1016/j.drugalcdep.2013.02.004.Peer-Reviewed Original ResearchConceptsVeterans Affairs Health Care SystemHazardous drinkingVeterans Aging Cohort StudyAlcohol useAging Cohort StudyLogistic regression modelsHealth care systemCohort studyVA careOlder veteransAlcohol abuseAlcohol misuseEarly interventionBrief interventionAlcohol dependenceHazardous useLow levelsBaselineCare systemRisk of homelessnessCareVeteransDrinkingRiskHousing stability
2006
Rate and predictors of treatment prescription for hepatitis C
Butt AA, Justice AC, Skanderson M, Rigsby MO, Good CB, Kwoh CK. Rate and predictors of treatment prescription for hepatitis C. Gut 2006, 56: 385. PMID: 17005764, PMCID: PMC1856823, DOI: 10.1136/gut.2006.099150.Peer-Reviewed Original ResearchConceptsHepatitis C virusNational Patient Care DatabaseTreatment prescriptionPrescription ratesAlcohol abuseVeterans Affairs National Patient Care DatabaseDiagnosis of HCVPharmacy Benefits Management databaseMultivariate logistic regression modelHepatitis B infectionCoronary artery diseasePatient Care DatabasePsychiatric comorbid conditionsNon-white raceLogistic regression analysisPredictors of treatmentAlcohol use diagnosisLogistic regression modelsB infectionComorbid illnessesHepatitis CArtery diseaseLiver cirrhosisComorbid conditionsHispanic race
2003
Differences in Symptom Expression in Older HIV-Positive Patients: The Veterans Aging Cohort 3 Site Study and HIV Cost and Service Utilization Study Experience
Zingmond DS, Kilbourne AM, Justice AC, Wenger NS, RodriguezBarradas M, Rabeneck L, Taub D, Weissman S, Briggs J, Wagner J, Smola S, Bozzette SA. Differences in Symptom Expression in Older HIV-Positive Patients: The Veterans Aging Cohort 3 Site Study and HIV Cost and Service Utilization Study Experience. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2003, 33: s84-s92. PMID: 12853857, DOI: 10.1097/00126334-200306012-00005.Peer-Reviewed Original ResearchConceptsOlder HIVHIV CostOlder HIV-positive patientsMultivariate logistic regression modelHIV-positive patientsServices Utilization StudyCross-sectional studyLogistic regression modelsCD4 countHIV diseasePeripheral neuropathyUnadjusted comparisonsHair lossIndividual symptomsSymptom recognitionHIVUtilization studiesDisease severityPatient careCertain symptomsSymptomsOlder ageDepressed moodWeight lossLower likelihood
1999
The Relationship Between Clinical Assessments of Nutritional Status and Adverse Outcomes in Older Hospitalized Medical Patients
Covinsky K, Martin G, Beyth R, Justice A, Sehgal A, Landefeld C. The Relationship Between Clinical Assessments of Nutritional Status and Adverse Outcomes in Older Hospitalized Medical Patients. Journal Of The American Geriatrics Society 1999, 47: 532-538. PMID: 10323645, DOI: 10.1111/j.1532-5415.1999.tb02566.x.Peer-Reviewed Original ResearchConceptsNursing home useAcute illness severityAdverse outcomesIllness severityNutritional statusClinical assessmentMalnourished patientsHospital admissionSubjective Global AssessmentProspective cohort studyTertiary care hospitalHome useIndex of comorbidityGeneral medical servicesPhysical exam findingsHospitalized older peopleYear of dischargeLogistic regression modelsNourished patientsSurrogate interviewsHospital outcomesChart reviewCohort studyCare hospitalHospitalized patients