2017
FIB‐4 stage of liver fibrosis predicts incident heart failure among HIV‐infected and uninfected patients
So‐Armah K, Lim JK, Re V, Tate JP, Chang C, Butt AA, Gibert CL, Rimland D, Marconi VC, Goetz MB, Rodriguez‐Barradas M, Budoff MJ, Tindle HA, Samet JH, Justice AC, Freiberg MS, Team F. FIB‐4 stage of liver fibrosis predicts incident heart failure among HIV‐infected and uninfected patients. Hepatology 2017, 66: 1286-1295. PMID: 28543215, PMCID: PMC5609079, DOI: 10.1002/hep.29285.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusFibrosis/cirrhosisHIV/HCV statusAdvanced fibrosis/cirrhosisLiver fibrosisCHF eventsHCV statusFIB-4Hepatitis CAdvanced liver fibrosis/cirrhosisIncident CHFCongestive heart failure riskCardiovascular disease risk factorsVeterans Aging Cohort StudyProportional hazards regression modelsLiver fibrosis/cirrhosisIncident CHF eventsRisk of CHFFibrosis-4 indexIncident heart failureDisease risk factorsHeart failure riskAging Cohort StudyCardiovascular disease riskPrevalent cardiovascular diseaseRisk of Acute Liver Injury After Statin Initiation by Human Immunodeficiency Virus and Chronic Hepatitis C Virus Infection Status
Byrne DD, Tate JP, Forde KA, Lim JK, Goetz MB, Rimland D, Rodriguez-Barradas MC, Butt AA, Gibert CL, Brown ST, Bedimo R, Freiberg MS, Justice AC, Kostman JR, Roy JA, Re V. Risk of Acute Liver Injury After Statin Initiation by Human Immunodeficiency Virus and Chronic Hepatitis C Virus Infection Status. Clinical Infectious Diseases 2017, 65: 1542-1550. PMID: 29020184, PMCID: PMC5850026, DOI: 10.1093/cid/cix564.Peer-Reviewed Original ResearchConceptsSevere acute liver injuryAcute liver injuryHuman immunodeficiency virusStatin initiatorsLower riskHCV statusCohort studyHazard ratioStatin nonusersLiver injuryUninfected personsImmunodeficiency virusChronic hepatitis C virus (HCV) infectionHepatitis C virus (HCV) infection statusHIV/HCV-coinfected patientsPropensity score-adjusted hazard ratiosHIV/HCV statusHepatitis C virus infectionVeterans Aging Cohort StudyC virus infectionAging Cohort StudyConfidence intervalsVirus infection statusDevelopment of liverAminotransferase elevation
2016
Hepatic Safety of Buprenorphine in HIV-Infected and Uninfected Patients With Opioid Use Disorder: The Role of HCV-Infection
Tetrault JM, Tate JP, Edelman EJ, Gordon AJ, Re V, Lim JK, Rimland D, Goulet J, Crystal S, Gaither JR, Gibert CL, Rodriguez-Barradas MC, Fiellin LE, Bryant K, Justice AC, Fiellin DA. Hepatic Safety of Buprenorphine in HIV-Infected and Uninfected Patients With Opioid Use Disorder: The Role of HCV-Infection. Journal Of Substance Use And Addiction Treatment 2016, 68: 62-67. PMID: 27431048, PMCID: PMC4976086, DOI: 10.1016/j.jsat.2016.06.002.Peer-Reviewed Original ResearchConceptsLiver enzyme elevationAlcohol use disorderUninfected patientsHepatotoxic medicationsHCV infectionUse disordersComposite endpointLiver injuryHIV/HCV co-infected patientsHCV co-infected patientsHIV/HCV statusPre-existing liver injuryCo-infected patientsCohort of HIVHepatitis C infectionHIV/HCVOpioid use disorderRisk of hepatotoxicityHCV statusHepatic safetyMedian ALTC infectionChart reviewEnzyme elevationHIV infection
2015
Injection Drug Use and Hepatitis C as Risk Factors for Mortality in HIV-Infected Individuals
May MT, Justice AC, Birnie K, Ingle SM, Smit C, Smith C, Neau D, Guiguet M, Schwarze-Zander C, Moreno S, Guest JL, Monforte A, Tural C, Gill MJ, Bregenzer A, Kirk O, Saag M, Sterling TR, Crane HM, Sterne JA. Injection Drug Use and Hepatitis C as Risk Factors for Mortality in HIV-Infected Individuals. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2015, 69: 348-354. PMID: 25848927, PMCID: PMC4506784, DOI: 10.1097/qai.0000000000000603.Peer-Reviewed Original ResearchConceptsInjection drug useDrug useLiver-related mortalityHepatitis C infectionEffect of HCVMortality hazard ratioNorth American cohortHCV coinfectionHCV statusAntiretroviral therapyC infectionHepatitis CHazard ratioSurvival differencesRisk factorsExcess mortalityPoor survivalRisk groupsHCVAmerican cohortHIVNew treatmentsMortalitySubstantial proportionComplete data
2014
Relationship Between Alcohol Use Categories and Noninvasive Markers of Advanced Hepatic Fibrosis in HIV-Infected, Chronic Hepatitis C Virus–Infected, and Uninfected Patients
Lim JK, Tate JP, Fultz SL, Goulet JL, Conigliaro J, Bryant KJ, Gordon AJ, Gibert C, Rimland D, Goetz MB, Klein MB, Fiellin DA, Justice AC, Re V. Relationship Between Alcohol Use Categories and Noninvasive Markers of Advanced Hepatic Fibrosis in HIV-Infected, Chronic Hepatitis C Virus–Infected, and Uninfected Patients. Clinical Infectious Diseases 2014, 58: 1449-1458. PMID: 24569533, PMCID: PMC4001286, DOI: 10.1093/cid/ciu097.Peer-Reviewed Original ResearchConceptsChronic hepatitis C virusAdvanced hepatic fibrosisHuman immunodeficiency virusHepatitis C virusAlcohol use categoriesAlcohol-related diagnosesHIV/HCV-coinfected patientsHepatic fibrosisAlcohol consumptionNonhazardous drinkingBinge drinkingHIV/HCV groupAlcohol Use Disorders Identification Test-Consumption (AUDIT-C) questionnaireVeterans Aging Cohort StudyFIB-4 indexAging Cohort StudyCross-sectional studyHCV groupHCV statusHIV-InfectedUninfected participantsChronic hepatitisUninfected patientsCohort studyLiver disease
2013
Acetaminophen receipt among HIV‐infected patients with advanced hepatic fibrosis
Edelman EJ, Gordon KS, Re V, Skanderson M, Fiellin DA, Justice AC, Team F. Acetaminophen receipt among HIV‐infected patients with advanced hepatic fibrosis. Pharmacoepidemiology And Drug Safety 2013, 22: 1352-1356. PMID: 24285468, PMCID: PMC4164158, DOI: 10.1002/pds.3517.Peer-Reviewed Original ResearchConceptsAdvanced hepatic fibrosisAcetaminophen exposureHCV statusHepatic fibrosisHIV/HCV-coinfected patientsVeterans Aging Cohort StudyAdvanced liver fibrosisAging Cohort StudyAcetaminophen-induced hepatotoxicitySample of HIVCross-sectional associationsPolytomous logistic regressionAlcohol use disorderCross-sectional analysisAcetaminophen prescriptionsAcetaminophen useHIV-monoinfectedFIB-4Cohort studyLiver injuryPlatelet countLiver fibrosisAlanine aminotransferaseHIVPatients
2012
Does an Index Composed of Clinical Data Reflect Effects of Inflammation, Coagulation, and Monocyte Activation on Mortality Among Those Aging With HIV?
Justice AC, Freiberg MS, Tracy R, Kuller L, Tate JP, Goetz MB, Fiellin DA, Vanasse GJ, Butt AA, Rodriguez-Barradas MC, Gibert C, Oursler KA, Deeks SG, Bryant K, Team T. Does an Index Composed of Clinical Data Reflect Effects of Inflammation, Coagulation, and Monocyte Activation on Mortality Among Those Aging With HIV? Clinical Infectious Diseases 2012, 54: 984-994. PMID: 22337823, PMCID: PMC3297653, DOI: 10.1093/cid/cir989.Peer-Reviewed Original ResearchConceptsHIV-1 RNANet reclassification improvementHepatitis C virusD-dimerIL-6VACS IndexMonocyte activationVeterans Aging Cohort Study (VACS) IndexHuman immunodeficiency virus type 1 (HIV-1) RNAFIB-4 indexGlomerular filtration rateMarkers of liverRoutine clinical variablesCopies/mLPrediction of mortalityEffects of inflammationHCV statusAntiretroviral therapyCD4 countRenal injuryReclassification improvementClinical variablesC-statisticC virusFiltration rate
2011
The Risk of Incident Coronary Heart Disease Among Veterans With and Without HIV and Hepatitis C
Freiberg MS, Chang CC, Skanderson M, McGinnis K, Kuller LH, Kraemer KL, Rimland D, Goetz MB, Butt AA, Barradas M, Gibert C, Leaf D, Brown ST, Samet J, Kazis L, Bryant K, Justice AC. The Risk of Incident Coronary Heart Disease Among Veterans With and Without HIV and Hepatitis C. Circulation Cardiovascular Quality And Outcomes 2011, 4: 425-432. PMID: 21712519, PMCID: PMC3159506, DOI: 10.1161/circoutcomes.110.957415.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusHepatitis C virusHIV-HCVCensoring eventVeterans Aging Cohort Study Virtual CohortIncident coronary heart diseaseCoronary heart disease riskHeart disease riskCoronary heart diseaseHIV-1 RNARisk of CHDIncidence of CHDHCV statusVeteran EnrolleesAdjusted riskAntiretroviral therapyCD4 countCHD eventsHCV infectionHepatitis CCHD riskImmunodeficiency virusC virusHeart diseaseRisk factors