2020
Alcohol Use and Antiretroviral Adherence Among Patients Living with HIV: Is Change in Alcohol Use Associated with Change in Adherence?
Williams EC, McGinnis KA, Rubinsky AD, Matson TE, Bobb JF, Lapham GT, Edelman EJ, Satre DD, Catz SL, Richards JE, Bryant KJ, Marshall BDL, Kraemer KL, Crystal S, Gordon AJ, Skanderson M, Fiellin DA, Justice AC, Bradley KA. Alcohol Use and Antiretroviral Adherence Among Patients Living with HIV: Is Change in Alcohol Use Associated with Change in Adherence? AIDS And Behavior 2020, 25: 203-214. PMID: 32617778, PMCID: PMC7775874, DOI: 10.1007/s10461-020-02950-x.Peer-Reviewed Original ResearchConceptsAlcohol useAntiretroviral therapyLow-level alcohol useInitial adherenceAntiretroviral adherenceAdherence interventionsAdherence decreasesAlcohol use increasesScreening scoresLongitudinal associationsAdherencePLWHHIVAnnual changesLinear regression modelsStable scoresRegression modelsScoresSmall annual changesDynamic longitudinal associationsAssociationUse increasesPatientsTherapy
2018
Efficacy of Extended-Release Naltrexone on HIV-Related and Drinking Outcomes Among HIV-Positive Patients: A Randomized-Controlled Trial
Edelman EJ, Moore BA, Holt SR, Hansen N, Kyriakides TC, Virata M, Brown ST, Justice AC, Bryant KJ, Fiellin DA, Fiellin LE. Efficacy of Extended-Release Naltrexone on HIV-Related and Drinking Outcomes Among HIV-Positive Patients: A Randomized-Controlled Trial. AIDS And Behavior 2018, 23: 211-221. PMID: 30073637, PMCID: PMC6476298, DOI: 10.1007/s10461-018-2241-z.Peer-Reviewed Original ResearchConceptsHIV-positive patientsHeavy drinking daysVACS Index scoreXR-NTXART adherenceDrinking daysIndex scoreUndetectable HIV viral loadCD4 cell countExtended-release naltrexoneDouble-blind placeboHIV viral loadRandomized-controlled trialDrinking outcomesHIV biomarkersSecondary outcomesHIV outcomesPrimary outcomeViral loadAntiretroviral adherenceClinical trialsCell countAlcohol treatmentHIVPatients
2015
Incarceration and health outcomes in HIV‐infected patients: The impact of substance use, primary care engagement, and antiretroviral adherence
Wang EA, McGinnis KA, Long JB, Akgün KM, Edelman EJ, Rimland D, Wang KH, Justice AC, Fiellin DA. Incarceration and health outcomes in HIV‐infected patients: The impact of substance use, primary care engagement, and antiretroviral adherence. American Journal On Addictions 2015, 24: 178-184. PMID: 25662297, PMCID: PMC4397180, DOI: 10.1111/ajad.12177.Peer-Reviewed Original ResearchConceptsVeterans Aging Cohort StudyHistory of incarcerationHIV disease outcomeVACS Index scorePrimary care engagementAntiretroviral adherenceCare engagementDisease outcomeIndex scoreDrug useHigher VACS Index scoresHealth of HIVAging Cohort StudyUnhealthy alcohol useViral RNA loadRecent drug useLow CD4Cohort studyRNA loadDrug treatmentHIVHealth outcomesMultivariate analysisMediation analysisPatients
2013
Personal Health Record Use and Its Association with Antiretroviral Adherence: Survey and Medical Record Data from 1871 US Veterans Infected with HIV
Keith McInnes D, Shimada SL, Rao SR, Quill A, Duggal M, Gifford AL, Brandt CA, Houston TK, Ohl ME, Gordon KS, Mattocks KM, Kazis LE, Justice AC. Personal Health Record Use and Its Association with Antiretroviral Adherence: Survey and Medical Record Data from 1871 US Veterans Infected with HIV. AIDS And Behavior 2013, 17: 3091-3100. PMID: 23334359, DOI: 10.1007/s10461-012-0399-3.Peer-Reviewed Original ResearchConceptsPersonal health record useMedical record dataPHR useAntiretroviral adherenceElectronic personal health record useVeterans Aging Cohort StudyRecord useHIV care processesMedication possession ratioAging Cohort StudyPharmacy refill dataRecord dataImproved patient outcomesCross-sectional surveyCohort studyPossession ratioDepression careRefill dataMedication adherenceUS veteransPatient outcomesAdherence measuresCare processesSocio-demographic variablesAdherence
2012
Antiretroviral Adherence Among Rural Compared to Urban Veterans with HIV Infection in the United States
Ohl ME, Perencevich E, McInnes DK, Kim N, Rimland D, Akgun K, Fiellin DA, Skanderson M, Wang K, Justice A. Antiretroviral Adherence Among Rural Compared to Urban Veterans with HIV Infection in the United States. AIDS And Behavior 2012, 17: 174-180. PMID: 23080359, DOI: 10.1007/s10461-012-0325-8.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-Retroviral AgentsConfidence IntervalsFemaleFollow-Up StudiesHIV InfectionsHumansLogistic ModelsMaleMedication AdherenceMiddle AgedOdds RatioResidence CharacteristicsRetrospective StudiesRural PopulationSocioeconomic FactorsUnited StatesUnited States Department of Veterans AffairsUrban PopulationVeteransConceptsRural-dwelling personsAntiretroviral therapyAntiretroviral adherenceUrban veteransRural-Urban Commuting Area codesVeterans Affairs Healthcare SystemCombination antiretroviral therapyHepatitis C infectionMultivariable logistic regressionSubstance use disordersC infectionHIV infectionRemote residentsHigh adherenceWhite raceVA healthcareUse disordersMedian proportionLogistic regressionAdherenceHealthcare systemRemote settingsTherapyInfectionFace barriers
2010
Evaluating Interventions to Improve Antiretroviral Adherence: How Much of an Effect Is Required for Favorable Value?
Braithwaite RS, Fiellin DA, Nucifora K, Bryant K, Roberts M, Kim N, Justice AC. Evaluating Interventions to Improve Antiretroviral Adherence: How Much of an Effect Is Required for Favorable Value? Value In Health 2010, 13: 535-542. PMID: 20345544, PMCID: PMC3032536, DOI: 10.1111/j.1524-4733.2010.00714.x.Peer-Reviewed Original ResearchConceptsAbsolute risk reductionNonadherent patientsAdherence interventionsRelative riskRisk factorsAntiretroviral therapy adherence interventionsEffect sizeNonadherence risk factorsBehavioral risk factorsHIV careAntiretroviral adherencePatientsNonadherenceSocietal perspectiveIncremental costIntervention costsSmall effect sizesLife expectancyInterventionRisk reductionPlausible effect sizes
2007
Estimating the impact of alcohol consumption on survival for HIV+ individuals
Braithwaite RS, Conigliaro J, Roberts MS, Shechter S, Schaefer A, McGinnis K, Rodriguez MC, Rabeneck L, Bryant K, Justice AC. Estimating the impact of alcohol consumption on survival for HIV+ individuals. AIDS Care 2007, 19: 459-466. PMID: 17453583, PMCID: PMC3460376, DOI: 10.1080/09540120601095734.Peer-Reviewed Original ResearchConceptsAlcohol consumptionFrequency of consumptionDaily consumptionModifiable risk factorsLarge observational cohortHazardous alcohol consumptionDose-response relationshipImpact of alcoholHIV diseaseObservational cohortOverall survivalAntiretroviral adherencePoor outcomeRisk factorsPoor survivalClinical dataHazardous drinkersNonhazardous drinkersAdherence resultsAlcohol's impactSurvivalWeeksDrinkersAdherenceYearsExplaining variability in the relationship between antiretroviral adherence and HIV mutation accumulation
Braithwaite R, Shechter S, Roberts M, Schaefer A, Bangsberg D, Harrigan P, Justice A. Explaining variability in the relationship between antiretroviral adherence and HIV mutation accumulation. Journal Of Antimicrobial Chemotherapy 2007, 59: 821-821. DOI: 10.1093/jac/dkm027.Peer-Reviewed Original ResearchAntiretroviral adherence
2001
Patient- and provider-reported adherence toward a clinically useful approach to measuring antiretroviral adherence
Wagner JH, Justice AC, Chesney M, Sinclair G, Weissman S, Rodriguez-Barradas M, Team F. Patient- and provider-reported adherence toward a clinically useful approach to measuring antiretroviral adherence. Journal Of Clinical Epidemiology 2001, 54: s91-s98. PMID: 11750214, DOI: 10.1016/s0895-4356(01)00450-4.Peer-Reviewed Original ResearchConceptsAlcohol Use Disorders Identification TestViral loadProvider assessmentCurrent drug useDepressive symptomsCurrent alcohol usePatient reportsDrug useAlcohol useIndependent associationVeterans Affairs Health Care SystemPatient-reported adherenceCurrent viral loadPharmacy refill dataAntiretroviral medication adherenceEpidemiological Studies DepressionIllicit drug useDisorders Identification TestElectronic laboratory dataHealth care systemRefill dataMedication adherencePatient adherenceAntiretroviral adherenceMultivariate regression model