2019
Immunoepidemiology of Plasmodium falciparum malaria
Bei A, Parikh S. Immunoepidemiology of Plasmodium falciparum malaria. 2019, 193-213. DOI: 10.1007/978-3-030-25553-4_12.Peer-Reviewed Original Research
2017
Genetic relatedness analysis reveals the cotransmission of genetically related Plasmodium falciparum parasites in Thiès, Senegal
Wong W, Griggs AD, Daniels RF, Schaffner SF, Ndiaye D, Bei AK, Deme AB, MacInnis B, Volkman SK, Hartl DL, Neafsey DE, Wirth DF. Genetic relatedness analysis reveals the cotransmission of genetically related Plasmodium falciparum parasites in Thiès, Senegal. Genome Medicine 2017, 9: 5. PMID: 28118860, PMCID: PMC5260019, DOI: 10.1186/s13073-017-0398-0.Peer-Reviewed Original ResearchConceptsPolygenomic infectionsRelatedness of strainsMalaria elimination activitiesPlasmodium falciparum parasitesPublic health interventionsEpidemiology modelFalciparum parasitesHealth interventionsDrug resistanceInfectionParasite populationsConclusionsOur findingsCotransmissionSuperinfection modelElimination activitiesTransmission intensityGenetic relatedness analysisGenetic profileInterventionParasitesMajor contributorPatientsPopulationSuperinfectionThiès
2013
Plasmodium falciparum Merozoite Surface Antigen, PfRH5, Elicits Detectable Levels of Invasion-Inhibiting Antibodies in Humans
Patel SD, Ahouidi AD, Bei AK, Dieye TN, Mboup S, Harrison SC, Duraisingh MT. Plasmodium falciparum Merozoite Surface Antigen, PfRH5, Elicits Detectable Levels of Invasion-Inhibiting Antibodies in Humans. The Journal Of Infectious Diseases 2013, 208: 1679-1687. PMID: 23904294, PMCID: PMC3805239, DOI: 10.1093/infdis/jit385.Peer-Reviewed Original ResearchConceptsMerozoite surface antigenSurface antigenPlasmodium falciparum merozoite surface antigenMulti-subunit vaccineMillions of infectionsIntracellular protozoan parasiteInvasion inhibition assaysSubstantial morbidityClinical isolatesP. falciparumBlood stagesPlasmodium falciparumNatural infectionAntibodiesPfRH5Protozoan parasiteDetectable levelsInhibition assaysInfectionAntigenFalciparumRecombinant formMorbidityLaboratory strainsVaccineExpansion of host cellular niche can drive adaptation of a zoonotic malaria parasite to humans
Lim C, Hansen E, DeSimone TM, Moreno Y, Junker K, Bei A, Brugnara C, Buckee CO, Duraisingh MT. Expansion of host cellular niche can drive adaptation of a zoonotic malaria parasite to humans. Nature Communications 2013, 4: 1638. PMID: 23535659, PMCID: PMC3762474, DOI: 10.1038/ncomms2612.Peer-Reviewed Original ResearchConceptsRed blood cellsParasite densityP. knowlesiHuman bloodPlasmodium falciparum infectionMalaria parasite Plasmodium knowlesiYoung red blood cellsZoonotic malaria parasiteHigh parasite densityOld red blood cellsFalciparum infectionClinical infectionSevere diseaseWide age rangeNormal human bloodPlasmodium knowlesiMalaria parasitesBlood cellsImportant zoonosisAge rangeInfectionBloodKnowlesiYoung cellsCulture system
2012
Functional analysis of erythrocyte determinants of Plasmodium infection
Bei AK, Duraisingh MT. Functional analysis of erythrocyte determinants of Plasmodium infection. International Journal For Parasitology 2012, 42: 575-582. PMID: 22726752, PMCID: PMC3383627, DOI: 10.1016/j.ijpara.2012.03.006.Peer-Reviewed Original ResearchConceptsFunctional analysisErythrocyte determinantsObligate intracellular pathogensPlasmodium infectionTransgenic approachesHuman erythrocytes resultsNatural variationErythrocyte invasionIntracellular pathogensPlasmodium falciparum parasitesUnexplored frontierClinical manifestationsMalaria researchErythrocytes resultsFalciparum parasitesInvasionMalarial diseaseChemical biologicalInfectionErythrocytesParasitesPathogensDeterminantsRemodellingDiscovery
2011
Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum
Crosnier C, Bustamante LY, Bartholdson SJ, Bei AK, Theron M, Uchikawa M, Mboup S, Ndir O, Kwiatkowski DP, Duraisingh MT, Rayner JC, Wright GJ. Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum. Nature 2011, 480: 534-537. PMID: 22080952, PMCID: PMC3245779, DOI: 10.1038/nature10606.Peer-Reviewed Original ResearchConceptsPlasmodium falciparum merozoitesInvasion of erythrocytesMalaria infectionFalciparum merozoitesAntimalarial therapeuticsP. falciparumBlood stagesPlasmodium falciparumErythrocyte invasionParasite invasionInvasionFalciparumReceptor essentialField strainsBasiginErythrocytesPfRH5VaccineInfectionAntibodies
2009
Trypanosoma cruzi Triggers an Early Type I IFN Response In Vivo at the Site of Intradermal Infection
Chessler AD, Unnikrishnan M, Bei AK, Daily JP, Burleigh BA. Trypanosoma cruzi Triggers an Early Type I IFN Response In Vivo at the Site of Intradermal Infection. The Journal Of Immunology 2009, 182: 2288-2296. PMID: 19201883, DOI: 10.4049/jimmunol.0800621.Peer-Reviewed Original ResearchConceptsInfection of miceIFN responseT. cruzi-infected miceIFN-gamma-deficient miceIFN-gamma-producing cellsLevels of IFNEarly type IType I IFN receptorInnate immune responseIntradermal infection modelEarly host responseSite of infectionType I IFNT. cruziI IFN receptorLocal infection siteSite of inoculationType IIntradermal infectionImmune responseI IFNPrimary siteHost responseIFN receptorInfection