2007
α2A-Adrenoceptors Strengthen Working Memory Networks by Inhibiting cAMP-HCN Channel Signaling in Prefrontal Cortex
Wang M, Ramos BP, Paspalas CD, Shu Y, Simen A, Duque A, Vijayraghavan S, Brennan A, Dudley A, Nou E, Mazer JA, McCormick DA, Arnsten AF. α2A-Adrenoceptors Strengthen Working Memory Networks by Inhibiting cAMP-HCN Channel Signaling in Prefrontal Cortex. Cell 2007, 129: 397-410. PMID: 17448997, DOI: 10.1016/j.cell.2007.03.015.Peer-Reviewed Original ResearchConceptsHCN channel blockadePrefrontal cortical neuronsDelay-related firingΑ2A adrenoceptorsChannel blockadeCortical neuronsInhibition of cAMPAlpha2A adrenoceptorsDendritic spinesNetwork firingElectrophysiological studiesPFC neuronsRecurrent excitationFunctional connectivityHCN channelsPrefrontal cortexHCN1 channelsPFC networksCAMP inhibitionStimulationBlockade
1984
Selective prefrontal cortical projections to the region of the locus coeruleus and raphe nuclei in the rhesus monkey
Arnsten A, Goldman-Rakic PS. Selective prefrontal cortical projections to the region of the locus coeruleus and raphe nuclei in the rhesus monkey. Brain Research 1984, 306: 9-18. PMID: 6466989, DOI: 10.1016/0006-8993(84)90351-2.Peer-Reviewed Original ResearchConceptsRaphe nucleusLocus coeruleusDorsal prefrontal cortexInferior temporal gyrusCortical areasPrefrontal cortexCortical projectionsRhesus monkeysTemporal gyrusAnterograde labeling techniquesCentral superior raphe nucleiPrefrontal cortical projectionsNoradrenergic locus coeruleusContralateral locus coeruleusParietal association cortexSuperior raphe nucleusDorsolateral prefrontal cortexSerotonergic dorsalLabeled fibersCerebral cortexCortical injectionsOrbital prefrontal cortexMonoaminergic innervationRaphe regionSomatosensory cortex
1983
Naloxone augments electrophysiological signs of selective attention in man
Arnsten A, Segal D, Neville H, Hillyard S, Janowsky D, Judd L, Bloom F. Naloxone augments electrophysiological signs of selective attention in man. Nature 1983, 304: 725-727. PMID: 6888538, DOI: 10.1038/304725a0.Peer-Reviewed Original ResearchConceptsEndogenous opioid systemOpioid systemSelective attentionOpiate antagonist naloxoneSelective information processingNormal human subjectsAntagonist naloxoneOpiate antagonistElectrophysiological signsAuditory attentionOpioid roleElectrophysiological measuresGeneral arousalElectrophysiological evidenceInformation processingBehavioral functionsNaloxoneHuman subjectsSource of stimulusMenPrevious researchArousalAttentionAntagonist