2024
The meso-connectomes of mouse, marmoset, and macaque: network organization and the emergence of higher cognition
Magrou L, Joyce M, Froudist-Walsh S, Datta D, Wang X, Martinez-Trujillo J, Arnsten A. The meso-connectomes of mouse, marmoset, and macaque: network organization and the emergence of higher cognition. Cerebral Cortex 2024, 34: bhae174. PMID: 38771244, PMCID: PMC11107384, DOI: 10.1093/cercor/bhae174.Peer-Reviewed Original ResearchConceptsInter-areal connectionsVisual cortexPrimary visual cortexHigher cortical areasMacaque cortexPrimate specializationHigher cognitionPrimate cortexV1Working memory storageDendritic spine densityTop-down regulationPrefrontal cortexConnection structureSpine densityFunctional segregationCortical areasFrontal areasCortexConnectomeNetwork organizationMemory storageMultimodal association
1997
Pathogenesis of Tourette's Syndrome
Leckman J, Peterson B, Anderson G, Arnsten A, Pauls D, Cohen D. Pathogenesis of Tourette's Syndrome. Journal Of Child Psychology And Psychiatry 1997, 38: 119-142. PMID: 9232461, DOI: 10.1111/j.1469-7610.1997.tb01508.x.Peer-Reviewed Original ResearchMeSH KeywordsBasal GangliaBrainBrain MappingCerebral CortexChildHumansNerve NetNeurotransmitter AgentsPhenotypeTourette Syndrome
1990
Analysis of alpha-2 adrenergic agonist effects on the delayed nonmatch-to-sample performance of aged rhesus monkeys
Arnsten A, Goldman-Rakic PS. Analysis of alpha-2 adrenergic agonist effects on the delayed nonmatch-to-sample performance of aged rhesus monkeys. Neurobiology Of Aging 1990, 11: 583-590. PMID: 1980719, DOI: 10.1016/0197-4580(90)90021-q.Peer-Reviewed Original Research
1985
α2-Adrenergic Mechanisms in Prefrontal Cortex Associated with Cognitive Decline in Aged Nonhuman Primates
Arnsten A, Goldman-Rakic P. α2-Adrenergic Mechanisms in Prefrontal Cortex Associated with Cognitive Decline in Aged Nonhuman Primates. Science 1985, 230: 1273-1276. PMID: 2999977, DOI: 10.1126/science.2999977.Peer-Reviewed Original ResearchConceptsBeneficial effectsAlpha-adrenergic systemReceptor agonist clonidineAlpha 2 receptorsΑ2-adrenergic mechanismsAged nonhuman primatesDorsolateral prefrontal cortexAgonist clonidineSite of actionAged humansPharmacological profileAged nonhumanCognitive declineCognitive deficitsCognitive functionPrefrontal cortexDrug actionNonhuman primatesMemory disordersClonidineLesionsCortexCatecholamines and Cognitive Decline in Aged Nonhuman Primates
ARNSTEN A, GOLDMAN‐RAKIC P. Catecholamines and Cognitive Decline in Aged Nonhuman Primates. Annals Of The New York Academy Of Sciences 1985, 444: 218-234. PMID: 3925850, DOI: 10.1111/j.1749-6632.1985.tb37592.x.Peer-Reviewed Original Research
1984
Selective prefrontal cortical projections to the region of the locus coeruleus and raphe nuclei in the rhesus monkey
Arnsten A, Goldman-Rakic PS. Selective prefrontal cortical projections to the region of the locus coeruleus and raphe nuclei in the rhesus monkey. Brain Research 1984, 306: 9-18. PMID: 6466989, DOI: 10.1016/0006-8993(84)90351-2.Peer-Reviewed Original ResearchConceptsRaphe nucleusLocus coeruleusDorsal prefrontal cortexInferior temporal gyrusCortical areasPrefrontal cortexCortical projectionsRhesus monkeysTemporal gyrusAnterograde labeling techniquesCentral superior raphe nucleiPrefrontal cortical projectionsNoradrenergic locus coeruleusContralateral locus coeruleusParietal association cortexSuperior raphe nucleusDorsolateral prefrontal cortexSerotonergic dorsalLabeled fibersCerebral cortexCortical injectionsOrbital prefrontal cortexMonoaminergic innervationRaphe regionSomatosensory cortex
1983
Naloxone augments electrophysiological signs of selective attention in man
Arnsten A, Segal D, Neville H, Hillyard S, Janowsky D, Judd L, Bloom F. Naloxone augments electrophysiological signs of selective attention in man. Nature 1983, 304: 725-727. PMID: 6888538, DOI: 10.1038/304725a0.Peer-Reviewed Original ResearchConceptsEndogenous opioid systemOpioid systemSelective attentionOpiate antagonist naloxoneSelective information processingNormal human subjectsAntagonist naloxoneOpiate antagonistElectrophysiological signsAuditory attentionOpioid roleElectrophysiological measuresGeneral arousalElectrophysiological evidenceInformation processingBehavioral functionsNaloxoneHuman subjectsSource of stimulusMenPrevious researchArousalAttentionAntagonist