2013
NMDA Receptors Subserve Persistent Neuronal Firing during Working Memory in Dorsolateral Prefrontal Cortex
Wang M, Yang Y, Wang CJ, Gamo NJ, Jin LE, Mazer JA, Morrison JH, Wang XJ, Arnsten AF. NMDA Receptors Subserve Persistent Neuronal Firing during Working Memory in Dorsolateral Prefrontal Cortex. Neuron 2013, 77: 736-749. PMID: 23439125, PMCID: PMC3584418, DOI: 10.1016/j.neuron.2012.12.032.Peer-Reviewed Original ResearchConceptsPersistent firingDorsolateral prefrontal cortexAMPA receptorsPrefrontal cortexPrimate dorsolateral prefrontal cortexSystemic ketamine administrationPersistent neuronal firingAMPAR blockadePrimate dlPFCKetamine actionKetamine administrationNMDAR blockadeNMDA receptorsSystemic ketamineNetwork firingNeuronal firingAlzheimer's diseaseReceptor influencesImpair cognitionResponse cellsRecurrent excitationSensory stimulation
1997
Catecholamine regulation of the prefrontal cortex
Arnsten A. Catecholamine regulation of the prefrontal cortex. Journal Of Psychopharmacology 1997, 11: 151-162. PMID: 9208378, DOI: 10.1177/026988119701100208.Peer-Reviewed Original ResearchConceptsPrefrontal cortexAdrenergic receptorsAlpha-1 adrenergic receptorsPFC functionPFC cognitive functionAlpha 2A-adrenergic receptorD1 receptor stimulationTreatment of disordersCatecholamine regulationCatecholamine releaseDA stimulationCatecholamine stimulationD2 familyProminent symptomReceptor stimulationModulatory influencePFC dysfunctionCognitive functionSubcortical structuresReview evidenceDetrimental actionsCatecholamines dopamineReceptorsStimulationNorepinephrinePathogenesis of Tourette's Syndrome
Leckman J, Peterson B, Anderson G, Arnsten A, Pauls D, Cohen D. Pathogenesis of Tourette's Syndrome. Journal Of Child Psychology And Psychiatry 1997, 38: 119-142. PMID: 9232461, DOI: 10.1111/j.1469-7610.1997.tb01508.x.Peer-Reviewed Original ResearchMeSH KeywordsBasal GangliaBrainBrain MappingCerebral CortexChildHumansNerve NetNeurotransmitter AgentsPhenotypeTourette Syndrome
1985
Catecholamines and Cognitive Decline in Aged Nonhuman Primates
ARNSTEN A, GOLDMAN‐RAKIC P. Catecholamines and Cognitive Decline in Aged Nonhuman Primates. Annals Of The New York Academy Of Sciences 1985, 444: 218-234. PMID: 3925850, DOI: 10.1111/j.1749-6632.1985.tb37592.x.Peer-Reviewed Original Research