2020
Insights into Cognitive Disorders in Aging and Mental Illness: Molecular Influences on Circuits of the Prefrontal Cortex
Arnsten A. Insights into Cognitive Disorders in Aging and Mental Illness: Molecular Influences on Circuits of the Prefrontal Cortex. 2020 DOI: 10.1093/oxfordhb/9780190069162.013.4.Peer-Reviewed Original ResearchPrefrontal cortexAbsence of sensory stimulationGoal-directed behaviorTop-down controlWorking memoryPrefrontal microcircuitsAffective disordersDynamic network connectivityMental disordersArousal systemCognitive disordersMental illnessCortical synaptic connectivityAbstract thoughtCortexRepresentation of informationDisordersSensory stimulationSynaptic strengthAlzheimer's diseaseRecurrent excitatory connectionsSynaptic connectionsExcitatory connectionsSchizophreniaNetwork connectivity
2009
Stress signalling pathways that impair prefrontal cortex structure and function
Arnsten AF. Stress signalling pathways that impair prefrontal cortex structure and function. Nature Reviews Neuroscience 2009, 10: 410-422. PMID: 19455173, PMCID: PMC2907136, DOI: 10.1038/nrn2648.Peer-Reviewed Original ResearchConceptsPrefrontal functionMemory abilityUncontrollable stressPrefrontal cortex structurePrefrontal pyramidal cellsControl of behaviorCognitive abilitiesEmotional operationsPrefrontal networkImpair performanceMental illnessPrefrontal dysfunctionPrefrontal cortexPrefrontal gray matterPrefrontal neuronsMemory functionStress impairsPersistent firingNeurochemical environmentStress exposureNeurochemical eventsCortex structureHigh levelsEmotionsChronic stress
2006
Estrogen enhances stress-induced prefrontal cortex dysfunction: relevance to Major Depressive Disorder in women
Shansky R, Arnsten A. Estrogen enhances stress-induced prefrontal cortex dysfunction: relevance to Major Depressive Disorder in women. Dialogues In Clinical Neuroscience 2006, 8: 478-481. PMCID: PMC3181833.Peer-Reviewed Original ResearchMajor depressive disorderPost-traumatic stress disorderDepressive disorderPrevalence of MDDPrefrontal cortex dysfunctionMost anxiety disordersAnimal modelsMental illnessBrain regionsEstrogenStress disorderAnxiety disordersNeurobiological responsesWomenDisordersEffects of stressLiterature demonstratingMenGreater vulnerabilityBiological causesDysfunctionIllnessPrevalenceStress responseBrain