Age-Related Cognitive Deficits and Neurotransmitters
Arnsten A. Age-Related Cognitive Deficits and Neurotransmitters. Cerebral Cortex 1999, 14: 89-110. DOI: 10.1007/978-1-4615-4885-0_5.Peer-Reviewed Original ResearchAge-related changesCognitive deficitsAge-related cognitive declineAge-related cognitive deficitsAged monkeysHigher cortical functionsSimilar neuropathological changesCognitive declineCortical functionDeficitsMonoamine systemsLife spanMonkeysSimilar patternHumansCortexNeuropathological changesNonhuman primate modelPrimate modelα-1 noradrenergic receptor stimulation impairs prefrontal cortical cognitive function
Arnsten A, Mathew R, Ubriani R, Taylor J, Li B. α-1 noradrenergic receptor stimulation impairs prefrontal cortical cognitive function. Biological Psychiatry 1999, 45: 26-31. PMID: 9894572, DOI: 10.1016/s0006-3223(98)00296-0.Peer-Reviewed Original ResearchConceptsPrefrontal cortexCognitive functionPrefrontal cortical cognitive functionCortical cognitive functionsImpairs cognitive functionHigher cortical functionsMemory taskAlpha-1 adrenoceptorsMost antipsychotic medicationsAlternation performanceNoradrenergic turnoverCortical functionPhenylephrine responseAlpha-1 adrenoceptor stimulationNeuropsychiatric disordersAlpha-1 adrenergic antagonistAlpha-1 adrenergic agonistDisordersAntipsychotic medicationAnxietyHigh levelsPhenylephrine infusionAdrenoceptor stimulationAdrenergic antagonistsSecond messenger pathways