2020
Biochemical characterization of age‐related calcium‐cAMP‐PKA signaling dysregulation and its effect on tau pathology in rhesus monkey cortex
Leslie S, Datta D, Wang M, van Dyck C, Arnsten A, Nairn A. Biochemical characterization of age‐related calcium‐cAMP‐PKA signaling dysregulation and its effect on tau pathology in rhesus monkey cortex. Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.042017.Peer-Reviewed Original ResearchTau pathologyAge-related dysregulationAlzheimer's diseaseIntracellular calciumTau phosphorylationRhesus monkeysRat primary cortical culturesHuman post-mortem samplesVulnerable brain regionsSporadic Alzheimer's diseaseAmyloid-beta plaquesPrimary cortical culturesMain pathological hallmarksRhesus monkey cortexTau neurofibrillary tanglesYears of ageEarly-onset formAge-related vulnerabilityDorsolateral prefrontal cortexAge-related changesMonkey DLPFCPost-mortem samplesAD pathologyAmyloid pathologyUnknown etiology
1999
Age-Related Cognitive Deficits and Neurotransmitters
Arnsten A. Age-Related Cognitive Deficits and Neurotransmitters. Cerebral Cortex 1999, 14: 89-110. DOI: 10.1007/978-1-4615-4885-0_5.Peer-Reviewed Original ResearchAge-related changesCognitive deficitsAge-related cognitive declineAge-related cognitive deficitsAged monkeysHigher cortical functionsSimilar neuropathological changesCognitive declineCortical functionDeficitsMonoamine systemsLife spanMonkeysSimilar patternHumansCortexNeuropathological changesNonhuman primate modelPrimate model