2015
Heart rate and respiratory response to doxapram in patients with panic disorder
Martinez JM, Garakani A, Aaronson CJ, Gorman JM. Heart rate and respiratory response to doxapram in patients with panic disorder. Psychiatry Research 2015, 227: 32-38. PMID: 25819170, PMCID: PMC4420657, DOI: 10.1016/j.psychres.2015.03.001.Peer-Reviewed Original ResearchConceptsPD patientsLF/HFPanic disorderHealthy controlsAnticipatory anxietyPD subjectsParasympathetic componentRespiratory responsesLF/HF ratioSensation of dyspneaHeart rate variability indicesHigher sympathetic activityInjection of salinePanic statesSympathetic activityRespiratory abnormalitiesBrain stemRespiratory stimulantHeart rateParasympathetic responsePanic attacksPatientsExaggerated fear responsePanic symptomsHF ratioSchizotypal Personality Disorder
Garakani A, Siever L. Schizotypal Personality Disorder. 2015, 1-7. DOI: 10.1002/9781118625392.wbecp390.ChaptersSchizotypal personality disorderPersonality disorderLack of empathySchizophrenia spectrum disordersPatterns of functioningSpectrum disorderFocus of treatmentOccupational functioningCognitive deficitsMagical thinkingNeural abnormalitiesCognitive impairmentStereotyped behaviorDopamine agonistsAntipsychotic treatmentSchizophreniaChronic disordersFunctioningHealthy controlsHealthy relativesPsychiatric hospitalizationClinical linesDisordersPhenotypic associationsFamilial studies
2012
Cerebrospinal fluid levels of glutamate and corticotropin releasing hormone in major depression before and after treatment
Garakani A, Martinez JM, Yehuda R, Gorman JM. Cerebrospinal fluid levels of glutamate and corticotropin releasing hormone in major depression before and after treatment. Journal Of Affective Disorders 2012, 146: 262-265. PMID: 22840611, DOI: 10.1016/j.jad.2012.06.037.Peer-Reviewed Original Research
2011
PROINFLAMMATORY AND “RESILIENCY” PROTEINS IN THE CSF OF PATIENTS WITH MAJOR DEPRESSION
Martinez JM, Garakani A, Yehuda R, Gorman JM. PROINFLAMMATORY AND “RESILIENCY” PROTEINS IN THE CSF OF PATIENTS WITH MAJOR DEPRESSION. Depression And Anxiety 2011, 29: 32-38. PMID: 21898706, DOI: 10.1002/da.20876.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntidepressive Agents, Second-GenerationBrain-Derived Neurotrophic FactorCyclohexanolsDepressive Disorder, MajorFemaleHumansInflammationInflammation MediatorsInterleukin-1Interleukin-6MaleMiddle AgedNeuropeptide YSeverity of Illness IndexTumor Necrosis Factor-alphaUp-RegulationVenlafaxine HydrochlorideConceptsInflammatory cytokinesDepressed patientsHealthy controlsMajor depressionCSF cytokine levelsCSF of patientsCerebrospinal fluid levelsLumbar puncture procedureNormal comparison groupInflammatory hypothesisNPY concentrationsNPY levelsCytokine levelsIL-6Lumbar punctureClinical severityTreatment protocolIL-1CSF samplesPatientsNeuroprotective peptideFluid levelsSuicidal ideationPuncture procedureSmall sample size
2010
Heart Rate and Blood Pressure Changes During Autonomic Nervous System Challenge in Panic Disorder Patients
Martinez JM, Garakani A, Kaufmann H, Aaronson CJ, Gorman JM. Heart Rate and Blood Pressure Changes During Autonomic Nervous System Challenge in Panic Disorder Patients. Psychosomatic Medicine 2010, 72: 442-449. PMID: 20368476, DOI: 10.1097/psy.0b013e3181d972c2.Peer-Reviewed Original ResearchConceptsLower heart rate variabilityMean diastolic blood pressureHigher heart rateHeart rate variabilityDiastolic blood pressureBlood pressureHealthy controlsHeart ratePanic disorder patientsPD patientsLF/HFOrthostatic challengeSympathovagal balanceDisorder patientsHigher mean diastolic blood pressureGreater cardiac riskIllness severity ratingsLess ill patientsSystolic blood pressureBlood pressure changesSeverity of illnessHigher low-frequency componentsAutonomic nervous systemIll patientsCardiac risk