Modeling Strengthens Molecular Link between Circadian Polymorphisms and Major Mood Disorders
Liberman AR, Halitjaha L, Ay A, Ingram KK. Modeling Strengthens Molecular Link between Circadian Polymorphisms and Major Mood Disorders. Journal Of Biological Rhythms 2018, 33: 318-336. PMID: 29614896, DOI: 10.1177/0748730418764540.Peer-Reviewed Original ResearchConceptsSingle nucleotide polymorphismsCircadian phenotypesMammalian circadian clockCircadian gene expressionCLOCK polymorphismsClock gene mutationsRecent genetic studiesIntronic single nucleotide polymorphismKnockdown conditionsCircadian clockTranscription rateMolecular linkGene expressionCircadian genesMolecular mechanismsGenetic studiesFunction mutationsNucleotide polymorphismsLength polymorphismClock gene polymorphismsGenotypic associationPolymorphismGene variantsMutationsPhenotype