Linkage analysis in spinopontine atrophy: Correlation or HLA linkage with phenotypic findings in hereditary ataxia
Bale A, Bale S, Schlesinger S, McFarland H, Opitz J, Reynolds J. Linkage analysis in spinopontine atrophy: Correlation or HLA linkage with phenotypic findings in hereditary ataxia. American Journal Of Medical Genetics 1987, 27: 595-602. PMID: 3477098, DOI: 10.1002/ajmg.1320270312.Peer-Reviewed Original ResearchConceptsHLA linkageHereditary ataxiasLoss of proprioceptionNervous system signsExtraocular movement abnormalitiesNeuropathologic changesNeuropathological descriptionOlivopontocerebellar atrophyMovement abnormalitiesAffected family membersPathologic changesSystem signsLower limbsType 1AtrophyHLAPhenotypic findingsNegative resultsAtaxiaFamily membersPresent familyDysphagiaDysarthriaReflexAbnormalities