978-P: Rare Variants in Melanocortin 4 Receptor Gene (MC4R) Are Associated with Increased Visceral Fat and Altered Glucose Metabolism Independent of the Effect of Obesity in Children
GALUPPO B, MANNAM P, TRICO D, BALE A, CAPRIO S, SANTORO N. 978-P: Rare Variants in Melanocortin 4 Receptor Gene (MC4R) Are Associated with Increased Visceral Fat and Altered Glucose Metabolism Independent of the Effect of Obesity in Children. Diabetes 2022, 71 DOI: 10.2337/db22-978-p.Peer-Reviewed Original ResearchOral glucose tolerance testEffect of obesityIntrahepatic fatInsulin resistanceVisceral fatMelanocortin-4 receptor gene mutationsVariant groupsSimilar BMI z-scoresOverweight/obese youthRare variantsAbdominal fat distributionGlucose tolerance testLower insulin clearanceBMI z-scoreEarly-onset obesityBody fat percentageΒ-cell functionGreater visceral fatMelanocortin-4 receptor geneHigher plasma glucoseRegion of MC4RReceptor gene mutationsMetabolic sequelaeInsulin clearanceTolerance test