The GATA-1 Cofactor FOG-1 Recruits NuRD to Promote Normal Erythroid and Megakaryocyte Development and Maintain Lineage Fidelity by Restricting Mast Cell Gene Expression.
Gregory G, Wang Y, Hong W, Miccio A, Bersenev A, Yu X, Wang H, Choi J, Shelat S, Tong W, Poncz M, Blobel G. The GATA-1 Cofactor FOG-1 Recruits NuRD to Promote Normal Erythroid and Megakaryocyte Development and Maintain Lineage Fidelity by Restricting Mast Cell Gene Expression. Blood 2008, 112: 1373. DOI: 10.1182/blood.v112.11.1373.1373.Peer-Reviewed Original ResearchGATA-1/FOGFOG-1Megakaryocytic-erythroid progenitorsMast cell gene expressionCell gene expressionErythroid cellsGene expressionMegakaryocyte developmentCell lineagesLineage-specific transcription factorsLevel of GATA2Mast cell fateTissue-specific nuclear factorsGATA-1 activityCo-repressor complexCofactor FOG-1Mast cell genesMast cell-specific genesCell-specific genesGene expression patternsMast cell lineageMature erythroid cellsNucleosome remodelingCell fateGATA-1