Lnk Controls Hematopoietic Stem Cell Self-Renewal through Direct Interactions with JAK2 and Contributes to Oncogenic JAK2-Induced Myeloproliferative Diseases in Mice
Bersenev A, Wu C, Balcerek J, Tong W. Lnk Controls Hematopoietic Stem Cell Self-Renewal through Direct Interactions with JAK2 and Contributes to Oncogenic JAK2-Induced Myeloproliferative Diseases in Mice. Blood 2008, 112: 895. DOI: 10.1182/blood.v112.11.895.895.Peer-Reviewed Original ResearchOncogenic JAK2TPO stimulationHematopoietic stem cell homeostasisStem Cell Self-RenewalHematopoietic Stem Cell Self-RenewalDownstream signal transduction pathwaysStem cell homeostasisPhosphorylated tyrosine residuesAdaptor protein LNKCell Self-RenewalSignal transduction pathwaysPhysiological negative regulatorCell surface receptorsImportant signaling axisWild-type HSCsTransduction pathwaysGenetic evidenceJAK2 activationSelf-RenewalBiochemical experimentsLNK deficiencyNegative regulatorHSC poolHSC quiescenceJanus kinase