14-3-3 Regulates the Lnk/JAK2 Pathway In Hematopoietic Stem and Progenitor Cells
Balcerek J, Jiang J, Bersenev A, Song Y, Wu C, Tong W. 14-3-3 Regulates the Lnk/JAK2 Pathway In Hematopoietic Stem and Progenitor Cells. Blood 2010, 116: 86. DOI: 10.1182/blood.v116.21.86.86.Peer-Reviewed Original ResearchOncogenic JAK2HSPC expansionHematopoietic stemRegulation of JAK2Serine phosphorylation eventsTyrosine kinase JAK2Progenitor cell homeostasisLymphocyte adaptor proteinHSPC developmentPhosphorylation eventsAdaptor proteinScaffold proteinCellular processesSerine residuesKinase JAK2Lnk-/- miceGene productsCritical binding siteRegulatory mechanismsCell homeostasisHSPC homeostasisJAK2 activityInactive stateFunction mutationsJAK2 pathway