2009
FOG-1 Requires NuRD to Promote Hematopoiesis and Maintain Lineage Fidelity within the Megakaryocytic–Erythroid Compartment.
Gregory G, Miccio A, Bersenev A, Wang Y, Hong W, Zhang Z, Poncz M, Tong W, Blobel G. FOG-1 Requires NuRD to Promote Hematopoiesis and Maintain Lineage Fidelity within the Megakaryocytic–Erythroid Compartment. Blood 2009, 114: 702. DOI: 10.1182/blood.v114.22.702.702.Peer-Reviewed Original ResearchMegakaryocyte-erythroid progenitorsMast cell gene expressionCell gene expressionFOG-1Mast cell genesGATA-1Gene expressionLineage fidelityErythroid cellsCell genesGenome-wide transcriptome analysisTranscription factor GATA-1Epigenetic silencing mechanismsWide transcriptome analysisCofactor FOG-1Mast cell-specific genesStage-specific rolesCell-specific genesNuRD complexNucleosome remodelingGATA factorsSilencing mechanismNuRDTranscriptome analysisHematopoietic development
2008
The GATA-1 Cofactor FOG-1 Recruits NuRD to Promote Normal Erythroid and Megakaryocyte Development and Maintain Lineage Fidelity by Restricting Mast Cell Gene Expression.
Gregory G, Wang Y, Hong W, Miccio A, Bersenev A, Yu X, Wang H, Choi J, Shelat S, Tong W, Poncz M, Blobel G. The GATA-1 Cofactor FOG-1 Recruits NuRD to Promote Normal Erythroid and Megakaryocyte Development and Maintain Lineage Fidelity by Restricting Mast Cell Gene Expression. Blood 2008, 112: 1373. DOI: 10.1182/blood.v112.11.1373.1373.Peer-Reviewed Original ResearchGATA-1/FOGFOG-1Megakaryocytic-erythroid progenitorsMast cell gene expressionCell gene expressionErythroid cellsGene expressionMegakaryocyte developmentCell lineagesLineage-specific transcription factorsLevel of GATA2Mast cell fateTissue-specific nuclear factorsGATA-1 activityCo-repressor complexCofactor FOG-1Mast cell genesMast cell-specific genesCell-specific genesGene expression patternsMast cell lineageMature erythroid cellsNucleosome remodelingCell fateGATA-1