2019
Chromatin organization modulates the origin of heritable structural variations in human genome
Roychowdhury T, Abyzov A. Chromatin organization modulates the origin of heritable structural variations in human genome. Nucleic Acids Research 2019, 47: 2766-2777. PMID: 30773596, PMCID: PMC6451188, DOI: 10.1093/nar/gkz103.Peer-Reviewed Original Research
2015
Analysis of deletion breakpoints from 1,092 humans reveals details of mutation mechanisms
Abyzov A, Li S, Kim DR, Mohiyuddin M, Stütz AM, Parrish NF, Mu XJ, Clark W, Chen K, Hurles M, Korbel JO, Lam HY, Lee C, Gerstein MB. Analysis of deletion breakpoints from 1,092 humans reveals details of mutation mechanisms. Nature Communications 2015, 6: 7256. PMID: 26028266, PMCID: PMC4451611, DOI: 10.1038/ncomms8256.Peer-Reviewed Original ResearchMeSH KeywordsChromatinChromosome BreakpointsDNADNA ReplicationGene DeletionGenome, HumanHomologous RecombinationHumansMutationNucleotidesSequence DeletionConceptsNon-allelic homologous recombinationTemplate-switching eventsGenomic structural variantsDeletion breakpointsHi-C interactionsNon-homologous mechanismsRelaxed selectionGenomic averageHistone marksOpen chromatinGenomic sitesGermline cellsDNA replicationCell divisionDNA methylationHomologous recombinationGenome ProjectStructural variantsBasepair resolutionNearby SNPsMutation mechanismMicroinsertionsBreakpointsChromatinIndels