Molecular characterization of colorectal adenomas with and without malignancy reveals distinguishing genome, transcriptome and methylome alterations
Druliner B, Wang P, Bae T, Baheti S, Slettedahl S, Mahoney D, Vasmatzis N, Xu H, Kim M, Bockol M, O’Brien D, Grill D, Warner N, Munoz-Gomez M, Kossick K, Johnson R, Mouchli M, Felmlee-Devine D, Washechek-Aletto J, Smyrk T, Oberg A, Wang J, Chia N, Abyzov A, Ahlquist D, Boardman L. Molecular characterization of colorectal adenomas with and without malignancy reveals distinguishing genome, transcriptome and methylome alterations. Scientific Reports 2018, 8: 3161. PMID: 29453410, PMCID: PMC5816667, DOI: 10.1038/s41598-018-21525-4.Peer-Reviewed Original ResearchConceptsColorectal cancerManagement of polypsPolyp patientsPolyp groupMalignant polypsPrecursor lesionsColorectal adenomasResidual polypPolyp tissuesPolyp sizePolypsCancerAltered expressionMethylome alterationsPatientsWhole-genome sequencingTissueMore mutationsAlterationsExpression changesSignificant expression changesMolecular determinantsMethylation alterationsMolecular distinctionMolecular characterization