2020
Shear Stress Estimated by Quantitative Coronary Angiography Predicts Plaques Prone to Progress and Cause Events
Bourantas CV, Zanchin T, Torii R, Serruys PW, Karagiannis A, Ramasamy A, Safi H, Coskun AU, Koning G, Onuma Y, Zanchin C, Krams R, Mathur A, Baumbach A, Mintz G, Windecker S, Lansky A, Maehara A, Stone PH, Raber L, Stone GW. Shear Stress Estimated by Quantitative Coronary Angiography Predicts Plaques Prone to Progress and Cause Events. JACC Cardiovascular Imaging 2020, 13: 2206-2219. PMID: 32417338, DOI: 10.1016/j.jcmg.2020.02.028.Peer-Reviewed Original ResearchConceptsHigh endothelial shear stressEndothelial shear stressLipid-rich plaquesPlaque burdenCardiovascular eventsPlaque characteristicsMajor adverse cardiovascular eventsSmaller minimum lumen areaLow endothelial shear stressHigh-risk anatomyAdverse cardiovascular eventsUseful prognostic informationQuantitative coronary angiographyMinimum lumen areaPrediction of lesionsLipid-rich lesionsESS valuesCoronary angiographyIndependent predictorsMultivariable analysisHemodynamic variablesPrognostic valueVH-IVUSHemodynamic indicesPrognostic information
2013
Non-Fibroatheroma Lesion Phenotype and Long-Term Clinical Outcomes A Substudy Analysis From the PROSPECT Study
Dohi T, Mintz GS, McPherson JA, de Bruyne B, Farhat NZ, Lansky AJ, Mehran R, Weisz G, Xu K, Stone GW, Maehara A. Non-Fibroatheroma Lesion Phenotype and Long-Term Clinical Outcomes A Substudy Analysis From the PROSPECT Study. JACC Cardiovascular Imaging 2013, 6: 908-916. PMID: 23850249, DOI: 10.1016/j.jcmg.2013.04.008.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAge FactorsAgedAngina, UnstableChi-Square DistributionCoronary VesselsFemaleFibrosisHospitalizationHumansKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionNecrosisPercutaneous Coronary InterventionPhenotypePlaque, AtheroscleroticPredictive Value of TestsProportional Hazards ModelsProspective StudiesRisk FactorsSeverity of Illness IndexSex FactorsTime FactorsTreatment OutcomeUltrasonography, InterventionalVascular CalcificationConceptsMajor adverse cardiac eventsAcute coronary syndromeNonculprit lesionsClinical outcomesLong-term clinical outcomesVirtual histology intravascular ultrasoundPROSPECT studyCox proportional hazards modelAdverse cardiac eventsIntermediate-term prognosisSuccessful percutaneous interventionOverall plaque burdenLesion phenotypeFA lesionsProportional hazards modelSubstudy analysisCoronary syndromeCulprit lesionCardiac eventsPlaque burdenClinical eventsVH-IVUSPercutaneous interventionClinical impactHazards model