Strategies for Multivessel Revascularization in Patients with Diabetes
Farkouh ME, Domanski M, Sleeper LA, Siami FS, Dangas G, Mack M, Yang M, Cohen DJ, Rosenberg Y, Solomon SD, Desai AS, Gersh BJ, Magnuson EA, Lansky A, Boineau R, Weinberger J, Ramanathan K, Sousa JE, Rankin J, Bhargava B, Buse J, Hueb W, Smith CR, Muratov V, Bansilal S, King S, Bertrand M, Fuster V. Strategies for Multivessel Revascularization in Patients with Diabetes. New England Journal Of Medicine 2012, 367: 2375-2384. PMID: 23121323, DOI: 10.1056/nejmoa1211585.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionCoronary artery diseaseMultivessel coronary artery diseaseDrug-eluting stentsCABG groupPCI groupArtery diseaseMyocardial infarctionMedical therapyMean ageAdvanced coronary artery diseaseLow-density lipoprotein cholesterolAggressive medical therapyBenefit of CABGComposite of deathCoronary artery bypassNonfatal myocardial infarctionPatients' mean ageThree-vessel diseaseSystolic blood pressurePrimary outcome measureRate of deathMultivessel revascularizationNonfatal strokeCoronary interventionThe Future REvascularization Evaluation in patients with Diabetes mellitus: Optimal management of Multivessel disease (FREEDOM) trial: Clinical and angiographic profile at study entry
Bansilal S, Farkouh ME, Hueb W, Ogdie M, Dangas G, Lansky AJ, Cohen DJ, Magnuson EA, Ramanathan K, Tanguay JF, Muratov V, Sleeper LA, Domanski M, Bertrand ME, Fuster V. The Future REvascularization Evaluation in patients with Diabetes mellitus: Optimal management of Multivessel disease (FREEDOM) trial: Clinical and angiographic profile at study entry. American Heart Journal 2012, 164: 591-599. PMID: 23067919, PMCID: PMC4536808, DOI: 10.1016/j.ahj.2012.06.012.Peer-Reviewed Original ResearchConceptsMultivessel coronary artery diseasePercutaneous coronary interventionDiabetic patientsFREEDOM trialBaseline characteristicsContemporary coronary artery bypassFuture Revascularization EvaluationMean hemoglobin A1cMean SYNTAX scoreMultivessel Disease (FREEDOM) trialOptimal medical therapyOptimal revascularization strategyCoronary artery bypassRisk factor controlMedian diabetes durationPrior myocardial infarctionSystolic blood pressureCoronary artery diseaseDrug-eluting stentsLow-density lipoproteinAngiographic profileVascular medicationsArtery bypassDiabetes durationSYNTAX score