2008
Angiographic Surrogate End Points in Drug-Eluting Stent Trials A Systematic Evaluation Based on Individual Patient Data From 11 Randomized, Controlled Trials
Pocock SJ, Lansky AJ, Mehran R, Popma JJ, Fahy MP, Na Y, Dangas G, Moses JW, Pucelikova T, Kandzari DE, Ellis SG, Leon MB, Stone GW. Angiographic Surrogate End Points in Drug-Eluting Stent Trials A Systematic Evaluation Based on Individual Patient Data From 11 Randomized, Controlled Trials. Journal Of The American College Of Cardiology 2008, 51: 23-32. PMID: 18174032, DOI: 10.1016/j.jacc.2007.07.084.Peer-Reviewed Original ResearchConceptsDrug-eluting stentsBare metal stentsAngiographic measuresTLR riskEnd pointDifferent drug-eluting stentsPrimary end pointRisk of TLRFollow-up angiographyLower revascularization ratesSurrogate end pointsIndividual patient dataSuitable surrogate markerDES trialsRevascularization ratesTLR rateClinical restenosisControlled TrialsFuture trialsStent implantationStent trialsSurrogate marker
2000
Relation of coronary artery size to one-year clinical events after new device angioplasty of native coronary arteries (a New Approach to Coronary Intervention [NACI] Registry report)
Saucedo J, Popma J, Kennard E, Talley J, Lansky A, Leon M, Baim D, Investigators F. Relation of coronary artery size to one-year clinical events after new device angioplasty of native coronary arteries (a New Approach to Coronary Intervention [NACI] Registry report). The American Journal Of Cardiology 2000, 85: 166-171. PMID: 10955371, DOI: 10.1016/s0002-9149(99)00649-9.Peer-Reviewed Original ResearchConceptsReference vessel diameterNew device angioplastyNative coronary arteriesMinimal lumen diameterClinical eventsAngiographic outcomesCoronary arteryFinal minimal lumen diameterFinal percent diameter stenosisMajor adverse clinical eventsOne-year clinical eventsSmaller reference vessel diameterBaseline lesion characteristicsRisk of TLRCombined end pointAdverse clinical eventsCoronary artery diseaseCoronary Intervention RegistryEarly clinical eventsIncidence of deathSmall vesselsCoronary artery sizePercent diameter stenosisLesion revascularizationMultivessel disease