2023
Percutaneous Transluminal Angioplasty for Infrapopliteal Chronic Limb-Threatening Ischemia: A Systematic Review and Meta-analysis of Primary Patency and Binary Restenosis Rates.
Snyder D, Zilinyi R, Pruthi S, George S, Tirziu D, Lansky A, Mintz A, Sethi S, Parikh S. Percutaneous Transluminal Angioplasty for Infrapopliteal Chronic Limb-Threatening Ischemia: A Systematic Review and Meta-analysis of Primary Patency and Binary Restenosis Rates. Journal Of Endovascular Therapy 2023, 15266028231212133. PMID: 38008929, DOI: 10.1177/15266028231212133.Peer-Reviewed Original ResearchChronic limb-threatening ischemiaPercutaneous transluminal angioplastyBinary restenosis ratePrimary patencyPrimary patency rateBinary restenosisTransluminal angioplastyRestenosis rateFuture RCTsPatency ratesTrial dataChronic limb threatening ischemiaLimb threatening ischemiaLimb-threatening ischemiaRandom-effects modelMeta-analysis demonstrateIntermittent claudicationEndovascular therapyCochrane CENTRALPower calculationMeta-analysis estimatesControl armPatencyRCTsSystematic reviewTCT-627 Binary Restenosis Rates Following Percutaneous Transluminal Angioplasty for Below-the-Knee Chronic Limb-Threatening Ischemia: A Meta-Analysis of Randomized Controlled Trial Data
Snyder D, Zilinyi R, Pruthi S, George S, Tirziu D, Lansky A, Mintz A, Sethi S, Parikh S. TCT-627 Binary Restenosis Rates Following Percutaneous Transluminal Angioplasty for Below-the-Knee Chronic Limb-Threatening Ischemia: A Meta-Analysis of Randomized Controlled Trial Data. Journal Of The American College Of Cardiology 2023, 82: b252-b253. DOI: 10.1016/j.jacc.2023.09.638.Peer-Reviewed Original Research
2009
The GENESIS (Randomized, Multicenter Study of the Pimecrolimus-Eluting and Pimecrolimus/Paclitaxel-Eluting Coronary Stent System in Patients with De Novo Lesions of the Native Coronary Arteries) Trial
Verheye S, Agostoni P, Dawkins KD, Dens J, Rutsch W, Carrie D, Schofer J, Lotan C, Dubois CL, Cohen SA, Fitzgerald PJ, Lansky AJ. The GENESIS (Randomized, Multicenter Study of the Pimecrolimus-Eluting and Pimecrolimus/Paclitaxel-Eluting Coronary Stent System in Patients with De Novo Lesions of the Native Coronary Arteries) Trial. JACC Cardiovascular Interventions 2009, 2: 205-214. PMID: 19463427, DOI: 10.1016/j.jcin.2008.12.011.Peer-Reviewed Original ResearchConceptsPaclitaxel-eluting stentsMajor adverse cardiac event ratesAdverse cardiac event ratesSingle de novo lesionsMajor adverse clinical eventsStent late lumen lossEnd pointBinary angiographic restenosisCardiac event ratePrimary end pointSecondary end pointsDe novo lesionsRandomized multicenter trialAdverse clinical eventsStent late lossLate lumen lossNative coronary arteriesStent restenosis rateBare metal stentsAngiographic restenosisNovo lesionsCoronary angiographyMulticenter trialRestenosis rateLumen loss
2007
Cobalt chromium stent with antiproliferative for restenosis trial in India (COSTAR I).
Kaul U, Gupta RK, Mathur A, Dani S, Sapra R, Nayak PR, Lansky A, Cristea E, Carlier S, Gambone L, Litvack F. Cobalt chromium stent with antiproliferative for restenosis trial in India (COSTAR I). Indian Heart Journal 2007, 59: 165-72. PMID: 19122251.Peer-Reviewed Original ResearchConceptsStent late lossGroup 2Group 1Late lossI trialCoronary lesionsGroup 3De novo coronary lesionsSegment late lossBinary restenosis rateNative coronary lesionsNovo coronary lesionsMulti-center registryCoronary stent systemRelease formulationExtended-release formulationSmall-caliber vesselsCobalt-chromium stentNovo lesionsPrimary endpointRestenosis TrialRestenosis rateClinical outcomesFeasibility trialClinical results
2006
Drug-Eluting and Bare Nitinol Stents for the Treatment of Atherosclerotic Lesions in the Superficial Femoral Artery: Long-Term Results from the SIROCCO Trial
Duda SH, Bosiers M, Lammer J, Scheinert D, Zeller T, Oliva V, Tielbeek A, Anderson J, Wiesinger B, Tepe G, Lansky A, Jaff MR, Mudde C, Tielemans H, Beregi JP. Drug-Eluting and Bare Nitinol Stents for the Treatment of Atherosclerotic Lesions in the Superficial Femoral Artery: Long-Term Results from the SIROCCO Trial. Journal Of Endovascular Therapy 2006, 13: 701-710. PMID: 17154704, DOI: 10.1583/05-1704.1.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAlloysAngioplasty, BalloonAnti-Bacterial AgentsAtherosclerosisBlood Vessel Prosthesis ImplantationCoated Materials, BiocompatibleDouble-Blind MethodDrug CarriersFemaleFemoral ArteryHumansKaplan-Meier EstimateMaleMiddle AgedProspective StudiesProsthesis FailureRecurrenceSafetySirolimusStentsTreatment OutcomeConceptsChronic limb ischemiaAnkle-brachial indexBare stent groupRestenosis rateSirolimus groupLimb ischemiaStent groupSuperficial femoral artery occlusionType C lesionsDouble-blinded studySymptoms of claudicationBare nitinol stentsMajority of patientsSuperficial femoral arteryFemoral artery occlusionStent restenosis rateNitinol self-expanding stentsSelf-expanding stentsTypes of stentsTVR ratesTLR rateArtery occlusionC lesionsClinical outcomesDrug-Eluting
2005
Bifurcation Coronary Lesions Treated With the “Crush” Technique An Intravascular Ultrasound Analysis
Costa RA, Mintz GS, Carlier SG, Lansky AJ, Moussa I, Fujii K, Takebayashi H, Yasuda T, Costa JR, Tsuchiya Y, Jensen LO, Cristea E, Mehran R, Dangas GD, Iyer S, Collins M, Kreps EM, Colombo A, Stone GW, Leon MB, Moses JW. Bifurcation Coronary Lesions Treated With the “Crush” Technique An Intravascular Ultrasound Analysis. Journal Of The American College Of Cardiology 2005, 46: 599-605. PMID: 16098422, DOI: 10.1016/j.jacc.2005.05.034.Peer-Reviewed Original ResearchConceptsMinimum stent areaStent areaBifurcation lesionsSB ostiumDistal stentMain vesselCrush areaCrush stent techniqueIntravascular ultrasound findingsHigh restenosis rateSirolimus-eluting stentsBifurcation coronary lesionsIntravascular ultrasound analysisSide branch ostiumIncomplete appositionRestenosis rateCoronary lesionsUltrasound findingsMain lesionIVUS analysisCrush techniqueLesionsOstiumUltrasound analysisBranch ostiumGender-based outcomes after paclitaxel-eluting stent implantation in patients with coronary artery disease
Lansky AJ, Costa RA, Mooney M, Midei MG, Lui HK, Strickland W, Mehran R, Leon MB, Russell ME, Ellis SG, Stone GW, Investigators T. Gender-based outcomes after paclitaxel-eluting stent implantation in patients with coronary artery disease. Journal Of The American College Of Cardiology 2005, 45: 1180-1185. PMID: 15837246, DOI: 10.1016/j.jacc.2004.10.076.Peer-Reviewed Original ResearchConceptsTarget lesion revascularizationPaclitaxel-eluting stent implantationIndependent predictorsStent implantationTaxus stentPaclitaxel-eluting Taxus stentElective coronary interventionTAXUS-IV trialOnly independent predictorCoronary artery diseaseOne-year ratesGender-based outcomesBare metal stentsLesion revascularizationMore hypertensionAngiographic restenosisRenal insufficiencyCoronary interventionUnstable anginaArtery diseaseHeart failureRestenosis rateLess smokingFemale genderLate lossRandomized comparison of carbon ion–implanted stent versus bare metal stent in coronary artery disease: The Asian Pacific Multicenter Arthos Stent Study (PASS) trial
Kim YH, Lee CW, Hong MK, Park SW, Tahk SJ, Yang JY, Saito S, Santoso T, Quan L, Ge J, Weissman NJ, Lansky AJ, Mintz GS, Park SJ. Randomized comparison of carbon ion–implanted stent versus bare metal stent in coronary artery disease: The Asian Pacific Multicenter Arthos Stent Study (PASS) trial. American Heart Journal 2005, 149: 336-341. PMID: 15846274, DOI: 10.1016/j.ahj.2004.02.018.Peer-Reviewed Original ResearchConceptsMajor adverse cardiac eventsAngiographic restenosis rateLong-term outcomesLate lossRestenosis rateGroup 2Group 1Adverse cardiac eventsNative coronary lesionsNonfatal myocardial infarctionCoronary artery diseaseMulticenter clinical studyLesion revascularizationPrimary endpointSecondary endpointsBaseline characteristicsCardiac eventsArtery diseaseCoronary lesionsHospital eventsRandomized comparisonBare metalMyocardial infarctionClinical studiesInflammatory reaction
2004
High-dose 7-hexanoyltaxol-eluting stent with polymer sleeves for coronary revascularizationOne-year results from the SCORE randomized trial
GRUBE E, LANSKY A, HAUPTMANN K, DIMARIO C, DISCIASCIO G, COLOMBO A, SILBER S, STUMPF J, REIFART N, FAJADET J. High-dose 7-hexanoyltaxol-eluting stent with polymer sleeves for coronary revascularizationOne-year results from the SCORE randomized trial. Journal Of The American College Of Cardiology 2004, 44: 1368-1372. DOI: 10.1016/s0735-1097(04)01351-8.Peer-Reviewed Original ResearchConceptsRestenosis rateStent thrombosisMajor adverse cardiac event ratesAdverse cardiac event ratesDe novo coronary lesionsTarget vessel revascularization rateEnd pointNon-Q-wave MIAngiographic restenosis rateCardiac event rateNovo coronary lesionsPrimary end pointUnacceptable safety profileVessel revascularization rateMyocardial infarction rateOpen-label trialStent thrombosis ratesClinical end pointsOne-year resultsQuantitative coronary angiographyCoronary revascularizationRevascularization ratesInfarction rateCardiac deathCoronary angiographyHigh-dose 7-hexanoyltaxol-eluting stent with polymer sleeves for coronary revascularization One-year results from the SCORE randomized trial
Grube E, Lansky A, Hauptmann K, Di Mario C, Di Sciascio G, Colombo A, Silber S, Stumpf J, Reifart N, Fajadet J, Marzocchi A, Schofer J, Dumas P, Hoffmann R, Guagliumi G, Pitney M, Russell M. High-dose 7-hexanoyltaxol-eluting stent with polymer sleeves for coronary revascularization One-year results from the SCORE randomized trial. Journal Of The American College Of Cardiology 2004, 44: 1368-1372. PMID: 15464315, DOI: 10.1016/j.jacc.2004.06.054.Peer-Reviewed Original ResearchConceptsRestenosis rateStent thrombosisMajor adverse cardiac event ratesAdverse cardiac event ratesDe novo coronary lesionsTarget vessel revascularization rateEnd pointNon-Q-wave MIAngiographic restenosis rateCardiac event rateNovo coronary lesionsPrimary end pointUnacceptable safety profileVessel revascularization rateMyocardial infarction rateOpen-label trialStent thrombosis ratesClinical end pointsOne-year resultsQuantitative coronary angiographyCoronary revascularizationRevascularization ratesInfarction rateCardiac deathCoronary angiographySix- and Twelve-Month Results From First Human Experience Using Everolimus-Eluting Stents With Bioabsorbable Polymer
Grube E, Sonoda S, Ikeno F, Honda Y, Kar S, Chan C, Gerckens U, Lansky AJ, Fitzgerald PJ. Six- and Twelve-Month Results From First Human Experience Using Everolimus-Eluting Stents With Bioabsorbable Polymer. Circulation 2004, 109: 2168-2171. PMID: 15123533, DOI: 10.1161/01.cir.0000128850.84227.fd.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnticoagulantsCatheterizationCineangiographyCoated Materials, BiocompatibleComorbidityCoronary AngiographyCoronary RestenosisCoronary StenosisDrug ImplantsEverolimusFemaleFollow-Up StudiesGrowth InhibitorsHumansHyperplasiaImmunosuppressive AgentsLactic AcidMaleMiddle AgedMyocardial InfarctionPolyestersPolymersProspective StudiesSingle-Blind MethodSirolimusStainless SteelStentsTreatment OutcomeTunica IntimaUltrasonography, InterventionalConceptsEverolimus-eluting stentsBare metal stentsRestenosis rateMajor adverse cardiac event ratesAdverse cardiac event ratesDe novo coronary lesionsMajor adverse cardiac eventsPercent neointimal volumeSegment restenosis rateAdverse cardiac eventsCardiac event rateNovo coronary lesionsStent restenosis rateTwelve-month resultsFirst human experienceIntravascular ultrasound analysisInitial clinical experienceLate stent malappositionLate stent thrombosisStent neointimal hyperplasiaSignificant reductionRestenosis reductionCardiac eventsI trialCoronary lesionsGamma radiation for in‐stent restenosis: effect of lesion length on angiographic and clinical outcomes
Mehran R, Iakovou I, Dangas G, Lansky AJ, Stone GW, Mintz GS, Kent KM, Pichard AD, Satler LF, Fahy M, Leon MB, Waksman R. Gamma radiation for in‐stent restenosis: effect of lesion length on angiographic and clinical outcomes. Catheterization And Cardiovascular Interventions 2004, 61: 354-359. PMID: 14988895, DOI: 10.1002/ccd.10786.Peer-Reviewed Original ResearchConceptsISR groupLesion lengthClinical eventsIn-Stent Restenosis TrialBaseline lesion lengthLower late lossShort lesion groupTreatment of ISRStent restenosis lesionsLong-term outcomesRecurrent ISRRestenosis lesionsRestenosis TrialAngiographic outcomesISR lesionsRestenosis rateClinical outcomesWashington RadiationLate lossStent restenosisLumen dimensionsLong ISRRadiation treatmentPowerful predictorPatients
2003
Usefulness of the angiographic pattern of in-stent restenosis in predicting the success of gamma vascular brachytherapy
Costantini CO, Lansky AJ, Mintz GS, Shirai K, Dangas G, Mehran R, Stone GW, Leon MB. Usefulness of the angiographic pattern of in-stent restenosis in predicting the success of gamma vascular brachytherapy. The American Journal Of Cardiology 2003, 92: 1214-1217. PMID: 14609602, DOI: 10.1016/j.amjcard.2003.07.036.Peer-Reviewed Original ResearchConceptsStent restenosisAngiographic patternsVascular brachytherapyMajor adverse cardiac event ratesAdverse cardiac event ratesBinary angiographic restenosis rateAngiographic restenosis rateCardiac event rateStent restenosis patternsRestenosis patternLesion revascularizationPrognostic roleRestenosis rateTotal occlusionClinical trialsProliferative patternEvent ratesRestenosisPooled data setBrachytherapyRevascularizationPatientsAngiogramsBaselineTrialsBeta radiation in lesions > 15 mm: a START subgroup.
Heuser R, Laskey W, Lansky A, Popma J, Bonan R. Beta radiation in lesions > 15 mm: a START subgroup. Journal Of Invasive Cardiology 2003, 15: 641-3. PMID: 14608136.Peer-Reviewed Original ResearchConceptsPlacebo groupLong lesionsStent restenosisSTART trialMajor adverse cardiac eventsAngiographic lesion characteristicsIntracoronary beta radiationAdverse cardiac eventsBinary restenosis rateIncidence of recurrentMean lesion lengthSignificant reductionLesion revascularizationRecurrent restenosisVessel revascularizationAngiographic parametersCardiac eventsClinical restenosisPatient demographicsRestenosis rateCoronary lesionsStent thrombosisLesion characteristicsRadiation groupRadiation therapyIntravascular brachytherapy for native coronary ostial in-stent restenotic lesions
Costantini CO, Lansky AJ, Mintz GS, Shirai K, Dangas G, Mehran R, Fahy M, Slack S, Coral M, Teirstein PS, Waksman R, Stone G, Moses J, Leon MB. Intravascular brachytherapy for native coronary ostial in-stent restenotic lesions. Journal Of The American College Of Cardiology 2003, 41: 1725-1731. PMID: 12767655, DOI: 10.1016/s0735-1097(03)00298-5.Peer-Reviewed Original ResearchConceptsAorto-ostial lesionsVascular brachytherapyRecurrence rateOstial ISRRestenosis rateStent restenosisBaseline lesion lengthStent restenotic lesionsHigh recurrence rateBinary restenosisPercutaneous reinterventionPlacebo patientsISR lesionsRestenotic lesionsQuantitative angiographyBeta patientsPatientsPooled databaseConventional treatmentRestenosisPlaceboLesionsLesion lengthBrachytherapySimilar reduction
2002
Balloon‐based radiation therapy for treatment of in‐stent restenosis in human coronary arteries: Results from the BRITE I study
Waksman R, Buchbinder M, Reisman M, Lansky AJ, Trauthen B, Whiting J, Li A. Balloon‐based radiation therapy for treatment of in‐stent restenosis in human coronary arteries: Results from the BRITE I study. Catheterization And Cardiovascular Interventions 2002, 57: 286-294. PMID: 12410499, DOI: 10.1002/ccd.10359.Peer-Reviewed Original ResearchMeSH KeywordsAgedArteriesBlood Vessel ProsthesisCatheterizationCoronary AngiographyCoronary RestenosisDose-Response Relationship, RadiationFemaleFollow-Up StudiesHumansIncidenceMaleMiddle AgedPilot ProjectsProspective StudiesRadiotherapy, Computer-AssistedReoperationRisk FactorsStentsTime FactorsTreatment OutcomeConceptsStent restenosisRadiation therapyMajor adverse cardiac eventsAdverse cardiac eventsIntracoronary radiation therapyStudy eligibility criteriaStent restenosis resultsInstances of deathHuman coronary arteriesBinary restenosisRepeat PTCAPrimary endpointCardiac eventsClinical restenosisEmergency surgeryLate complicationsAngioplasty siteRestenosis rateRecurrence rateTotal occlusionConventional therapyCoronary arteryEligibility criteriaLate thrombosisTarget vessel7-Hexanoyltaxol–Eluting Stent for Prevention of Neointimal Growth
Kataoka T, Grube E, Honda Y, Morino Y, Hur SH, Bonneau HN, Colombo A, Di Mario C, Guagliumi G, Hauptmann KE, Pitney MR, Lansky AJ, Stertzer SH, Yock PG, Fitzgerald PJ. 7-Hexanoyltaxol–Eluting Stent for Prevention of Neointimal Growth. Circulation 2002, 106: 1788-1793. PMID: 12356631, DOI: 10.1161/01.cir.0000031734.11420.1c.Peer-Reviewed Original ResearchConceptsBare metal stentsNeointimal growthIntravascular ultrasoundDe novo coronary lesionsAdjacent reference segmentsNovo coronary lesionsIndependent core laboratoryHuman feasibility studyNeointimal tissue growthIVUS substudyUnhealed dissectionConventional mechanical treatmentMulticenter trialCoronary lesionsRestenosis rateAtherosclerotic diseaseIntracoronary brachytherapyIVUS analysisNeointimal responseLong-term benefitsNeointimal thickeningStented segmentsCore laboratoryMetal stentsReference segmentsLocalized intracoronary beta radiation therapy to inhibit recurrence of in-stent restenosis
Waksman R, Raizner A, Yeung A, Lansky A, Vandertie L, on behalf of the INHIBIT Investigators. Localized intracoronary beta radiation therapy to inhibit recurrence of in-stent restenosis. Clinical Research In Cardiology 2002, 91: 40-41. DOI: 10.1007/s00392-002-1307-z.Peer-Reviewed Original ResearchTarget lesion revascularizationMajor adverse cardiac eventsPrimary safety endpointTarget vessel revascularizationLesion revascularizationStent restenosisMyocardial infarctionSafety endpointRestenosis rateRadiated groupLong lesionsRadiation therapyBinary angiographic restenosis rateIntracoronary beta-radiation therapyBeta-radiation therapyIntracoronary beta radiationSuccessful coronary interventionAdverse cardiac eventsAngiographic restenosis ratePrimary efficacy endpointIntracoronary radiation therapyRecurrence of restenosisCentering catheterOverall revascularizationEfficacy endpointResults of the Jostent coronary stent graft implantation in various clinical settings: Procedural and follow‐up results
Gercken U, Lansky AJ, Buellesfeld L, Desai K, Badereldin M, Mueller R, Selbach G, Leon MB, Grube E. Results of the Jostent coronary stent graft implantation in various clinical settings: Procedural and follow‐up results. Catheterization And Cardiovascular Interventions 2002, 56: 353-360. PMID: 12112888, DOI: 10.1002/ccd.10223.Peer-Reviewed Original ResearchConceptsCoronary stent graftSaphenous vein graftsOverall restenosis rateStent graftRestenosis rateCoronary perforationStent restenosisAntiplatelet therapyVein graftsStent implantationComplex lesionsStent edgeStainless steel stentsHigh primary success ratePrimary angiographic success rateAngiographic success ratePrimary success ratePTFE layerIntravascular ultrasound guidanceLate lumen lossStent-graft implantationVein graft lesionsQ-wave MIComplex lesion subsetsTransient ventricular fibrillationFive-year clinical and angiographic follow-up after intracoronary iridium-192 radiation therapy
Condado JA, Waksman R, Saucedo JF, Bhargava B, Lansky AJ, Calderas C, Gurdiel O, Gonzalez J, Fadoul M, Parra B, Iturria I, Amezaga B. Five-year clinical and angiographic follow-up after intracoronary iridium-192 radiation therapy. Cardiovascular Revascularization Medicine 2002, 3: 74-81. PMID: 12699836, DOI: 10.1016/s1522-1865(03)00077-5.Peer-Reviewed Original ResearchConceptsQuantitative coronary analysisIntracoronary gamma radiationBalloon angioplastyRadiation therapyAngiographic complicationsStandard balloon angioplastyBinary restenosis rateIntracoronary radiation therapyIncidence of restenosisNew adverse effectsPrevention of restenosisLesion revascularizationUnstable anginaAngioplasty siteRestenosis rateNontarget vesselsTotal occlusionMyocardial infarctionAngiographic effectsClinical trialsAneurysm formationLate lossNeointimal formationLong-term effectsPatients