2015
Pretreatment with aspirin in acute coronary syndromes: Lessons from the ACUITY and HORIZONS-AMI trials
Brener SJ, Mehran R, Lansky AJ, Ayele GM, Stone GW. Pretreatment with aspirin in acute coronary syndromes: Lessons from the ACUITY and HORIZONS-AMI trials. European Heart Journal Acute Cardiovascular Care 2015, 5: 449-454. PMID: 26722003, DOI: 10.1177/2048872615624848.Peer-Reviewed Original ResearchConceptsAcute coronary syndromeHORIZONS-AMI trialCoronary syndromeAspirin pretreatmentMyocardial infarctionCardiac deathStent thrombosisSegment elevation acute coronary syndromesST-segment elevation myocardial infarctionElevation acute coronary syndromeAcute coronary syndrome patientsLarge randomized clinical trialsAdverse ischemic eventsTarget vessel revascularizationCoronary syndrome patientsIndependent risk factorElevation myocardial infarctionLarge prospective studiesHigh-risk cohortIncidence of deathRandomized clinical trialsMultivariable regression analysisPrior revascularizationVessel revascularizationIschemic events
2006
Ischemic and bleeding outcomes in women treated with bivalirudin during percutaneous coronary intervention: A subgroup analysis of the Randomized Evaluation in PCI Linking Angiomax to Reduced Clinical Events (REPLACE)–2 trial
Chacko M, Lincoff AM, Wolski KE, Cohen DJ, Bittl JA, Lansky AJ, Tsuchiya Y, Betriu A, Yen MH, Chew DP, Cho L, Topol EJ. Ischemic and bleeding outcomes in women treated with bivalirudin during percutaneous coronary intervention: A subgroup analysis of the Randomized Evaluation in PCI Linking Angiomax to Reduced Clinical Events (REPLACE)–2 trial. American Heart Journal 2006, 151: 1032.e1-1032.e7. PMID: 16644331, DOI: 10.1016/j.ahj.2006.02.012.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryAnticoagulantsDrug Therapy, CombinationFemaleHemorrhageHeparinHirudinsHumansMaleMulticenter Studies as TopicMyocardial InfarctionMyocardial RevascularizationPeptide FragmentsPlatelet Glycoprotein GPIIb-IIIa ComplexRandomized Controlled Trials as TopicRecombinant ProteinsRetrospective StudiesRisk AssessmentSex FactorsConceptsPercutaneous coronary interventionIschemic end pointsComposite ischemic end pointsContemporary percutaneous coronary interventionGpIIb-IIIa blockadeEnd pointMajor bleedingCoronary interventionMyocardial infarctionSubgroup analysisProvisional glycoprotein IIb/IIIa blockadeGlycoprotein IIb/IIIa blockadeAccess site bleedingInherent bleeding riskPCI Linking AngiomaxCongestive heart failureSex-based subgroup analysisPrior revascularizationUrgent revascularizationBleeding riskMinor bleedingMore diabetesSite bleedingHeart failurePoor outcome