2020
Survival After Coronary Revascularization With Paclitaxel-Coated Balloons
Scheller B, Vukadinovic D, Jeger R, Rissanen TT, Scholz SS, Byrne R, Kleber FX, Latib A, Clever YP, Ewen S, Böhm M, Yang Y, Lansky A, Mahfoud F. Survival After Coronary Revascularization With Paclitaxel-Coated Balloons. Journal Of The American College Of Cardiology 2020, 75: 1017-1028. PMID: 32138961, DOI: 10.1016/j.jacc.2019.11.065.Peer-Reviewed Original ResearchConceptsDrug-coated balloonsPaclitaxel-coated balloonRisk of deathCause mortalityRisk ratioStent restenosisPaclitaxel drug-coated balloonPaclitaxel-coated devicesDe novo lesionsCoronary artery diseaseSuperficial femoral arteryCochrane Library databasesConfidence intervalsNumber of patientsWeb of ScienceCardiac mortalityCoronary revascularizationNovo lesionsCoronary interventionDCB groupDifferent time pointsArtery diseasePrimary outcomeFemoral arteryPeripheral arteries
2010
Comparison of Everolimus-Eluting and Paclitaxel-Eluting Coronary Stents in Patients Undergoing Multilesion and Multivessel Intervention The SPIRIT III (A Clinical Evaluation of the Investigational Device XIENCE V Everolimus Eluting Coronary Stent System [EECSS] in the Treatment of Subjects With De Novo Native Coronary Artery Lesions) and SPIRIT IV (Clinical Evaluation of the XIENCE V Everolimus Eluting Coronary Stent System in the Treatment of Subjects With De Novo Native Coronary Artery Lesions) Randomized Trials
Kereiakes DJ, Sudhir K, Hermiller JB, Gordon PC, Ferguson J, Yaqub M, Sood P, Su X, Yakubov S, Lansky AJ, Stone GW. Comparison of Everolimus-Eluting and Paclitaxel-Eluting Coronary Stents in Patients Undergoing Multilesion and Multivessel Intervention The SPIRIT III (A Clinical Evaluation of the Investigational Device XIENCE V Everolimus Eluting Coronary Stent System [EECSS] in the Treatment of Subjects With De Novo Native Coronary Artery Lesions) and SPIRIT IV (Clinical Evaluation of the XIENCE V Everolimus Eluting Coronary Stent System in the Treatment of Subjects With De Novo Native Coronary Artery Lesions) Randomized Trials. JACC Cardiovascular Interventions 2010, 3: 1229-1239. PMID: 21232716, DOI: 10.1016/j.jcin.2010.09.014.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, Balloon, CoronaryAntineoplastic Agents, PhytogenicCoronary Artery BypassCoronary Artery DiseaseDrug-Eluting StentsEverolimusFemaleHumansImmunosuppressive AgentsKaplan-Meier EstimateMaleMiddle AgedPaclitaxelRandomized Controlled Trials as TopicSirolimusTime FactorsUnited StatesConceptsPaclitaxel-eluting stentsIschemia-driven target lesion revascularizationTarget vessel myocardial infarctionSPIRIT IV trialTarget lesion revascularizationVessel myocardial infarctionLesion revascularizationMultivessel diseaseMultivessel interventionAbsolute benefitMyocardial infarctionOptimal revascularization strategySingle-vessel interventionDe novo lesionsReference vessel diameterEverolimus-ElutingMultilesion interventionEfficacy outcomesNovo lesionsRevascularization strategyCoronary diseaseClinical outcomesCoronary arteryClinical safetySingle lesion
2009
The GENESIS (Randomized, Multicenter Study of the Pimecrolimus-Eluting and Pimecrolimus/Paclitaxel-Eluting Coronary Stent System in Patients with De Novo Lesions of the Native Coronary Arteries) Trial
Verheye S, Agostoni P, Dawkins KD, Dens J, Rutsch W, Carrie D, Schofer J, Lotan C, Dubois CL, Cohen SA, Fitzgerald PJ, Lansky AJ. The GENESIS (Randomized, Multicenter Study of the Pimecrolimus-Eluting and Pimecrolimus/Paclitaxel-Eluting Coronary Stent System in Patients with De Novo Lesions of the Native Coronary Arteries) Trial. JACC Cardiovascular Interventions 2009, 2: 205-214. PMID: 19463427, DOI: 10.1016/j.jcin.2008.12.011.Peer-Reviewed Original ResearchConceptsPaclitaxel-eluting stentsMajor adverse cardiac event ratesAdverse cardiac event ratesSingle de novo lesionsMajor adverse clinical eventsStent late lumen lossEnd pointBinary angiographic restenosisCardiac event ratePrimary end pointSecondary end pointsDe novo lesionsRandomized multicenter trialAdverse clinical eventsStent late lossLate lumen lossNative coronary arteriesStent restenosis rateBare metal stentsAngiographic restenosisNovo lesionsCoronary angiographyMulticenter trialRestenosis rateLumen loss
2007
Clinical Outcomes After Heterogeneous Overlap Stenting With Drug-Eluting Stents and Bare-Metal Stents for de Novo Coronary Artery Narrowings
Aoki J, Kirtane AJ, Dangas GD, Lansky AJ, Morales A, Kimura M, Kim YH, Moussa I, Weisz G, Kreps EM, Collins M, Frankin-Bond T, Stone GW, Moses JW, Leon MB, Mehran R. Clinical Outcomes After Heterogeneous Overlap Stenting With Drug-Eluting Stents and Bare-Metal Stents for de Novo Coronary Artery Narrowings. The American Journal Of Cardiology 2007, 101: 58-62. PMID: 18157966, DOI: 10.1016/j.amjcard.2007.07.049.Peer-Reviewed Original ResearchConceptsDrug-eluting stentsBare metal stentsClinical outcomesTarget vessel revascularization rateMultiple drug-eluting stentsAcute stent thrombosisVessel revascularization rateDe novo lesionsTarget vessel revascularizationPercutaneous coronary interventionCoronary artery narrowingImplanted stent diameterNovo lesionsProspective registryRevascularization ratesVessel revascularizationBMS implantationCoronary interventionDES implantationConsecutive patientsArtery narrowingStent thrombosisMyocardial infarctionStent restenosisStent diameterNonrandomized Comparison of Coronary Stenting Under Intravascular Ultrasound Guidance of Direct Stenting Without Predilation Versus Conventional Predilation With a Semi-Compliant Balloon Versus Predilation With a New Scoring Balloon
de Ribamar Costa J, Mintz GS, Carlier SG, Mehran R, Teirstein P, Sano K, Liu X, Lui J, Na Y, Castellanos C, Biro S, Dani L, Rinker J, Moussa I, Dangas G, Lansky AJ, Kreps EM, Collins M, Stone GW, Moses JW, Leon MB. Nonrandomized Comparison of Coronary Stenting Under Intravascular Ultrasound Guidance of Direct Stenting Without Predilation Versus Conventional Predilation With a Semi-Compliant Balloon Versus Predilation With a New Scoring Balloon. The American Journal Of Cardiology 2007, 100: 812-817. PMID: 17719325, DOI: 10.1016/j.amjcard.2007.03.100.Peer-Reviewed Original ResearchConceptsIntravascular ultrasound guidanceMinimum stent areaStent expansionDirect stentingStent areaUltrasound guidanceStent diameterConsecutive de novo lesionsFinal minimum stent areaDrug-eluting stent eraDe novo lesionsReference vessel sizeSemi-compliant balloonMinimum stent diameterNovo lesionsCoronary stentingStent eraNonrandomized studyNonrandomized comparisonLesion preparationFinal stent expansionScoring balloonPredilationLesion morphologyDES expansionCobalt chromium stent with antiproliferative for restenosis trial in India (COSTAR I).
Kaul U, Gupta RK, Mathur A, Dani S, Sapra R, Nayak PR, Lansky A, Cristea E, Carlier S, Gambone L, Litvack F. Cobalt chromium stent with antiproliferative for restenosis trial in India (COSTAR I). Indian Heart Journal 2007, 59: 165-72. PMID: 19122251.Peer-Reviewed Original ResearchConceptsStent late lossGroup 2Group 1Late lossI trialCoronary lesionsGroup 3De novo coronary lesionsSegment late lossBinary restenosis rateNative coronary lesionsNovo coronary lesionsMulti-center registryCoronary stent systemRelease formulationExtended-release formulationSmall-caliber vesselsCobalt-chromium stentNovo lesionsPrimary endpointRestenosis TrialRestenosis rateClinical outcomesFeasibility trialClinical results
2000
Randomized Trial of Contrast Media Utilization in High-Risk PTCA
Davidson C, Laskey W, Hermiller J, Harrison J, Matthai W, Vlietstra R, Brinker J, Kereiakes D, Muhlestein J, Lansky A, Popma J, Buchbinder M, Hirshfeld J. Randomized Trial of Contrast Media Utilization in High-Risk PTCA. Circulation 2000, 101: 2172-2177. PMID: 10801758, DOI: 10.1161/01.cir.101.18.2172.Peer-Reviewed Original ResearchConceptsMajor adverse clinical eventsHospital major adverse clinical eventsPrimary end pointClinical eventsNonionic dimer iodixanolDimer iodixanolEnd pointLow-osmolar contrast agentsHigh-risk PTCAHospital clinical eventsThrombus-related eventsTotal clinical eventsDouble-blind trialAcute coronary syndromeHigh-risk patientsProspective multicenter trialAdverse clinical eventsCoronary artery interventionPTCA outcomeAngiographic successCoronary syndromeNovo lesionsArtery interventionMulticenter trialRandomized trialsOptimally deployed stents in the treatment of restenotic versus de novo lesions
Gruberg L, Hong M, Mintz G, Mehran R, Waksman R, Dangas G, Kent K, Pichard A, Satler L, Lansky A, Kornowski R, Stone G, Leon M. Optimally deployed stents in the treatment of restenotic versus de novo lesions. The American Journal Of Cardiology 2000, 85: 333-337. PMID: 11078302, DOI: 10.1016/s0002-9149(99)00742-0.Peer-Reviewed Original ResearchConceptsDe novo lesionsOptimal stent deploymentTarget lesion revascularizationEvent-free survivalVein graft lesionsNovo lesionsLong-term outcomesMinimal lumen diameterRestenotic lesionsStent deploymentLesion revascularizationGraft lesionsDiabetes mellitusMyocardial infarctionHigh incidenceNon-Q-wave myocardial infarctionDe novo lesions groupFinal minimal lumen diameterLumen diameterSaphenous vein graft lesionsIndependent risk factorDe novo groupIncidence of deathStent deployment techniquesStatistical significant difference
1998
Intracoronary Radiation Post PTCA Prevents Late Arterial Constriction
WAKSMAN R, CONDADO J, SAUCEDO J, LANSKY A, POPMA J, KLEIN J, CROCKER I, WILLIAMS D, KING S. Intracoronary Radiation Post PTCA Prevents Late Arterial Constriction. Journal Of Interventional Cardiology 1998, 11: 535-541. DOI: 10.1111/j.1540-8183.1998.tb00165.x.Peer-Reviewed Original ResearchPost-PTCABalloon angioplastyIntracoronary radiationLate lossLate loss indexLower late lossVascular remodeling effectDe novo lesionsIntracoronary radiation therapyPilot clinical studyMechanism of restenosisNovo lesionsRestenosis rateRadiation trialsPositive remodelingTotal occlusionArterial constrictionClinical studiesVascular remodelingRadiation therapyNeointima formationAnimal modelsPatientsRemodeling effectTrials