2015
Prognostic utility of myocardial blush grade after PCI in patients with NSTE‐ACS: Analysis from the ACUITY trial
Ng VG, Lansky AJ, Toro S, Parise H, Cristea E, Mehran R, Stone GW. Prognostic utility of myocardial blush grade after PCI in patients with NSTE‐ACS: Analysis from the ACUITY trial. Catheterization And Cardiovascular Interventions 2015, 88: 215-224. PMID: 25641255, DOI: 10.1002/ccd.25865.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedChi-Square DistributionCoronary AngiographyCoronary CirculationCoronary VesselsFemaleHumansKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisMyocardial Perfusion ImagingNon-ST Elevated Myocardial InfarctionOdds RatioPercutaneous Coronary InterventionPredictive Value of TestsProportional Hazards ModelsRisk AssessmentRisk FactorsTreatment OutcomeConceptsMyocardial blush gradePercutaneous coronary interventionST-segment elevation myocardial infarctionNSTE-ACS patientsComposite ischemiaMBG 0/1Non-ST segment elevation acute coronary syndromesSegment elevation acute coronary syndromesElevation acute coronary syndromeFinal myocardial blush gradeIndependent angiographic core laboratoryNet adverse clinical eventsNon-CABG major bleedingNormal epicardial flowOutcomes of patientsTIMI 3 flowAcute coronary syndromeIschemia-driven revascularizationAdverse clinical eventsElevation myocardial infarctionNormal myocardial perfusionAngiographic core laboratoryHigh rateACUITY trialMajor bleeding
2014
Impact of Cigarette Smoking on Extent of Coronary Artery Disease and Prognosis of Patients With Non–ST-Segment Elevation Acute Coronary Syndromes An Analysis From the ACUITY Trial (Acute Catheterization and Urgent Intervention Triage Strategy)
Robertson JO, Ebrahimi R, Lansky AJ, Mehran R, Stone GW, Lincoff AM. Impact of Cigarette Smoking on Extent of Coronary Artery Disease and Prognosis of Patients With Non–ST-Segment Elevation Acute Coronary Syndromes An Analysis From the ACUITY Trial (Acute Catheterization and Urgent Intervention Triage Strategy). JACC Cardiovascular Interventions 2014, 7: 372-379. PMID: 24630881, DOI: 10.1016/j.jcin.2013.11.017.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedChi-Square DistributionComorbidityCoronary AngiographyCoronary Artery DiseaseFemaleHemorrhageHumansKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionOdds RatioPercutaneous Coronary InterventionProportional Hazards ModelsProspective StudiesRisk AssessmentRisk FactorsSeverity of Illness IndexSmokingTime FactorsTreatment OutcomeTriageConceptsCoronary artery diseaseMyocardial infarctionACUITY trialMajor bleedingNSTE-ACSArtery diseaseSegment elevation acute coronary syndromesExtent of CADST-segment elevation myocardial infarctionElevation acute coronary syndromeHigh-risk NSTE-ACSSegment Elevation Acute CoronaryDiffuse coronary artery diseaseMyocardial infarction (TIMI) flowAcute coronary syndromeElevation myocardial infarctionPercutaneous coronary interventionPrognosis of patientsPresence of thrombusIncidence of deathLong-term outcomesAcute myocardial infarctionFavorable baseline characteristicsCoronary syndromeNon–STImpact of Nonculprit Vessel Myocardial Perfusion on Outcomes of Patients Undergoing Percutaneous Coronary Intervention for Acute Coronary Syndromes Analysis From the ACUITY Trial (Acute Catheterization and Urgent Intervention Triage Strategy)
Lansky AJ, Ng VG, Meller S, Xu K, Fahy M, Feit F, Ohman EM, White HD, Mehran R, Bertrand ME, Desmet W, Hamon M, Stone GW. Impact of Nonculprit Vessel Myocardial Perfusion on Outcomes of Patients Undergoing Percutaneous Coronary Intervention for Acute Coronary Syndromes Analysis From the ACUITY Trial (Acute Catheterization and Urgent Intervention Triage Strategy). JACC Cardiovascular Interventions 2014, 7: 266-275. PMID: 24650400, DOI: 10.1016/j.jcin.2013.08.016.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedCardiac CatheterizationCoronary AngiographyCoronary CirculationDouble-Blind MethodElectrocardiographyEmergenciesFemaleFollow-Up StudiesHumansMaleMiddle AgedMyocardial Perfusion ImagingPercutaneous Coronary InterventionPericardiumPractice Guidelines as TopicPrognosisProspective StudiesSurvival RateTriageUnited StatesConceptsPercutaneous coronary interventionMyocardial blush gradeNSTE-ACS patientsMBG 0/1Myocardial perfusionACUITY trialNonculprit vesselsCulprit vesselCoronary interventionSegment elevation acute coronary syndrome patientsST-segment elevation myocardial infarction (STEMI) patientsElevation acute coronary syndrome patientsOutcomes of PCIAcute Coronary Syndromes AnalysisTIMI flow grade 3Worse baseline clinical characteristicsAcute coronary syndrome patientsElevation myocardial infarction patientsLong-term mortality ratesInfarct-related vesselBaseline clinical characteristicsOutcomes of patientsCoronary syndrome patientsRisk-stratify patientsMyocardial infarction patientsIschemic Outcomes After Coronary Intervention of Calcified Vessels in Acute Coronary Syndromes Pooled Analysis From the HORIZONS-AMI (Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction) and ACUITY (Acute Catheterization and Urgent Intervention Triage Strategy) Trials
Généreux P, Madhavan MV, Mintz GS, Maehara A, Palmerini T, LaSalle L, Xu K, McAndrew T, Kirtane A, Lansky AJ, Brener SJ, Mehran R, Stone GW. Ischemic Outcomes After Coronary Intervention of Calcified Vessels in Acute Coronary Syndromes Pooled Analysis From the HORIZONS-AMI (Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction) and ACUITY (Acute Catheterization and Urgent Intervention Triage Strategy) Trials. Journal Of The American College Of Cardiology 2014, 63: 1845-1854. PMID: 24561145, DOI: 10.1016/j.jacc.2014.01.034.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionSevere target lesion calcificationAcute coronary syndromePercutaneous coronary interventionTarget lesion calcificationTarget lesion revascularizationElevation acute coronary syndromeDefinite stent thrombosisLesion calcificationStent thrombosisHORIZONS-AMICoronary syndromeCoronary interventionCoronary calcificationST-segment elevation acute coronary syndromeSegment elevation acute coronary syndromesIndependent angiographic core laboratoryStable coronary artery diseaseSevere lesion calcificationOne-year outcomesElevation myocardial infarctionCoronary artery diseaseAngiographic core laboratoryACUITY trialIschemic outcomes
2013
The impact of the coronary collateral circulation on outcomes in patients with acute coronary syndromes: results from the ACUITY trial
Meier P, Lansky AJ, Fahy M, Xu K, White HD, Bertrand ME, Mehran R, Stone GW. The impact of the coronary collateral circulation on outcomes in patients with acute coronary syndromes: results from the ACUITY trial. Heart 2013, 100: 647. PMID: 24310521, DOI: 10.1136/heartjnl-2013-304435.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedCollateral CirculationCoronary AngiographyCoronary Artery BypassCoronary CirculationFemaleFibrinolytic AgentsHumansKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionPercutaneous Coronary InterventionPredictive Value of TestsProportional Hazards ModelsRisk FactorsTime FactorsTreatment OutcomeConceptsMajor adverse cardiac eventsAcute coronary syndromeTarget vessel revascularisationPercutaneous coronary interventionAdverse cardiac eventsCoronary collateral circulationMyocardial infarctionCoronary syndromeCardiac eventsClinical outcomesCollateral circulationHigh-risk acute coronary syndromesUrgent Intervention Triage Strategy (ACUITY) trialIndependent angiographic core laboratorySubgroup of patientsCoronary collateral vesselsAngiographic core laboratoryPresence of collateralsACUITY trialAcute CatheterizationRentrop scoreVessel revascularisationMultivariable adjustmentCoronary interventionVisible collateralsPrognostic Utility of the SYNTAX Score in Patients With Single Versus Multivessel Disease Undergoing Percutaneous Coronary Intervention (from the Acute Catheterization and Urgent Intervention Triage StrategY [ACUITY] Trial)
Caixeta A, Généreux P, Palmerini T, Lansky AJ, Mehran R, Dangas GD, Xu K, Brener SJ, Stone GW. Prognostic Utility of the SYNTAX Score in Patients With Single Versus Multivessel Disease Undergoing Percutaneous Coronary Intervention (from the Acute Catheterization and Urgent Intervention Triage StrategY [ACUITY] Trial). The American Journal Of Cardiology 2013, 113: 203-210. PMID: 24176063, DOI: 10.1016/j.amjcard.2013.08.035.Peer-Reviewed Original ResearchConceptsMultivessel coronary artery diseaseMajor adverse cardiac eventsSingle-vessel diseasePercutaneous coronary interventionSurgery scoreCoronary interventionClinical outcomesMyocardial infarctionRate of MACETaxus drug-eluting stentsCardiac Surgery (SYNTAX) scoreOverall study cohortAdverse cardiac eventsCoronary artery diseaseDrug-eluting stentsACUITY trialMultivessel diseaseSS tertilesAngiographic predictorsSYNTAX scoreCardiac eventsThird tertileArtery diseaseCardiac deathIndependent predictorsIMPACT OF CORONARY CALCIFICATION ON ONE–YEAR OUTCOMES AFTER PCI IN STEMI AND NSTEMI: POOLED ANALYSIS FROM HORIZONS AND ACUITY TRIALS
Genereux P, Maehara A, Kirtane A, Brener S, Palmerini T, Lasalle L, McAndrew T, Lansky A, Mehran R, Mintz G, Stone G. IMPACT OF CORONARY CALCIFICATION ON ONE–YEAR OUTCOMES AFTER PCI IN STEMI AND NSTEMI: POOLED ANALYSIS FROM HORIZONS AND ACUITY TRIALS. Journal Of The American College Of Cardiology 2013, 61: e1716. DOI: 10.1016/s0735-1097(13)61716-7.Peer-Reviewed Original ResearchASSOCIATION BETWEEN CORONARY CALCIFICATION AND BLEEDING AFTER PCI IN ACS: POOLED ANALYSIS FROM HORIZONS-AMI AND ACUITY TRIALS
Genereux P, Maehara A, Kirtane A, Brener S, Palmerini T, Lasalle L, Sanidas E, Tarigopula M, Yadav M, McAndrew T, Fahy M, Lansky A, Mehran R, Mintz G, Stone G. ASSOCIATION BETWEEN CORONARY CALCIFICATION AND BLEEDING AFTER PCI IN ACS: POOLED ANALYSIS FROM HORIZONS-AMI AND ACUITY TRIALS. Journal Of The American College Of Cardiology 2013, 61: e143. DOI: 10.1016/s0735-1097(13)60144-8.Peer-Reviewed Original Research
2012
A New Score for Risk Stratification of Patients With Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention The ACUITY-PCI (Acute Catheterization and Urgent Intervention Triage Strategy–Percutaneous Coronary Intervention) Risk Score
Palmerini T, Genereux P, Caixeta A, Cristea E, Lansky A, Mehran R, Della Riva D, Fahy M, Xu K, Stone GW. A New Score for Risk Stratification of Patients With Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention The ACUITY-PCI (Acute Catheterization and Urgent Intervention Triage Strategy–Percutaneous Coronary Intervention) Risk Score. JACC Cardiovascular Interventions 2012, 5: 1108-1116. PMID: 23174634, DOI: 10.1016/j.jcin.2012.07.011.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionAcute coronary syndromeCoronary artery diseaseRisk scoreRisk stratificationCoronary syndromeCoronary interventionArtery diseaseElectrocardiographic variablesSegment elevation acute coronary syndromesElevation acute coronary syndromeDiffuse coronary artery diseaseCardiac biomarker elevationClinical SYNTAX scoreEarly invasive strategyGRACE risk scoreTIMI risk scoreInsulin-treated diabetesNet reclassification improvementNew scoreBetter prognostic accuracyST-segment deviationACUITY trialAngiographic substudyRenal insufficiencyTCT-480 Outcomes in Patients with Non-obstructive Coronary Artery Disease With and Without Cardiac Biomarker Elevations: The ACUITY Trial
Newman J, Dangas G, Brener S, Xu K, Genereux P, Lansky A, Nikolsky E, Mehran R, Stone G. TCT-480 Outcomes in Patients with Non-obstructive Coronary Artery Disease With and Without Cardiac Biomarker Elevations: The ACUITY Trial. Journal Of The American College Of Cardiology 2012, 60: b139. DOI: 10.1016/j.jacc.2012.08.512.Peer-Reviewed Original ResearchImplications of pre-procedural TIMI flow in patients with non ST-segment elevation acute coronary syndromes undergoing percutaneous coronary revascularization: Insights from the ACUITY trial
De Luca G, Brener SJ, Mehran R, Lansky AJ, McLaurin BT, Cox DA, Cristea E, Fahy M, Stone GW. Implications of pre-procedural TIMI flow in patients with non ST-segment elevation acute coronary syndromes undergoing percutaneous coronary revascularization: Insights from the ACUITY trial. International Journal Of Cardiology 2012, 167: 727-732. PMID: 22464479, DOI: 10.1016/j.ijcard.2012.03.058.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionPercutaneous coronary interventionAcute coronary syndromeHigh-risk patientsTIMI flowACUITY trialCoronary syndromeMyocardial infarctionNon-ST segment elevation acute coronary syndromesST-segment elevation acute coronary syndromePost-PCI TIMI 3 flowElevation acute coronary syndromeIndependent angiographic core laboratoryPre-procedural TIMI flowBaseline TIMI flowPre-PCI TIMIPreprocedural TIMI flowTIMI 3 flowEarly invasive managementElevation myocardial infarctionNegative prognostic impactPercutaneous coronary revascularizationAngiographic core laboratoryReduced ThrombolysisTIMI 0/1IMPACT OF INCOMPLETE CORONARY REVASCULARIZATION ON ONE-YEAR OUTCOMES AFTER PERCUTANEOUS CORONARY INTERVENTION IN ACUTE CORONARY SYNDROMES: THE ACUITY TRIAL
Rosner G, Kirtane A, Genereux P, Lansky A, Cristea E, Gersh B, Weisz G, Parise H, Mehran R, Stone G. IMPACT OF INCOMPLETE CORONARY REVASCULARIZATION ON ONE-YEAR OUTCOMES AFTER PERCUTANEOUS CORONARY INTERVENTION IN ACUTE CORONARY SYNDROMES: THE ACUITY TRIAL. Journal Of The American College Of Cardiology 2012, 59: e538. DOI: 10.1016/s0735-1097(12)60539-7.Peer-Reviewed Original ResearchPrognostic Significance of Elevated Baseline Troponin in Patients With Acute Coronary Syndromes and Chronic Kidney Disease Treated With Different Antithrombotic Regimens
Acharji S, Baber U, Mehran R, Fahy M, Kirtane AJ, Lansky AJ, Stone GW. Prognostic Significance of Elevated Baseline Troponin in Patients With Acute Coronary Syndromes and Chronic Kidney Disease Treated With Different Antithrombotic Regimens. Circulation Cardiovascular Interventions 2012, 5: 157-165. PMID: 22354934, DOI: 10.1161/circinterventions.111.963876.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAged, 80 and overBiomarkersFemaleFibrinolytic AgentsFollow-Up StudiesHeparinHirudinsHumansKidney Failure, ChronicMaleMyocardial InfarctionPeptide FragmentsPlatelet Glycoprotein GPIIb-IIIa ComplexPrognosisRecombinant ProteinsReference StandardsSurvival AnalysisTroponin TConceptsGlycoprotein IIb/IIIa inhibitorsAcute coronary syndromeBaseline troponin elevationChronic kidney diseaseMajor adverse cardiac eventsTroponin elevationMyocardial infarctionBivalirudin monotherapyMajor bleedingCKD patientsCoronary syndromeBaseline troponinKidney diseaseHigh-risk acute coronary syndromesIIb/IIIa inhibitorsLong-term clinical outcomesBaseline cardiac troponinBaseline troponin levelsDifferent antithrombotic regimensAdverse cardiac eventsACS patientsACUITY trialAntithrombotic regimensComposite deathRandomization arm
2011
Prognostic Significance of Coronary Thrombus in Patients Undergoing Percutaneous Coronary Intervention for Acute Coronary Syndromes A Subanalysis of the ACUITY (Acute Catheterization and Urgent Intervention Triage strategY) Trial
Goto K, Lansky AJ, Nikolsky E, Fahy M, Feit F, Ohman EM, White HD, Mehran R, Bertrand ME, Desmet W, Hamon M, Stone GW. Prognostic Significance of Coronary Thrombus in Patients Undergoing Percutaneous Coronary Intervention for Acute Coronary Syndromes A Subanalysis of the ACUITY (Acute Catheterization and Urgent Intervention Triage strategY) Trial. JACC Cardiovascular Interventions 2011, 4: 769-777. PMID: 21777885, DOI: 10.1016/j.jcin.2011.02.019.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionAcute coronary syndromeACUITY trialStent thrombosisMyocardial infarctionACS patientsCoronary interventionIndependent predictorsHigh-risk acute coronary syndromesSegment elevation acute coronary syndromesElevation acute coronary syndromeHigh-risk ACS patientsIndependent angiographic core laboratoryEpicardial coronary flowEarly invasive strategyRisk of deathHigh-risk populationAngiographic core laboratoryHigh rateBaseline angiographyCoronary syndromeIschemic complicationsAdjunctive pharmacotherapyCoronary thrombusPrognostic importancePrognostic Value of the SYNTAX Score in Patients With Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention Analysis From the ACUITY (Acute Catheterization and Urgent Intervention Triage StrategY) Trial
Palmerini T, Genereux P, Caixeta A, Cristea E, Lansky A, Mehran R, Dangas G, Lazar D, Sanchez R, Fahy M, Xu K, Stone GW. Prognostic Value of the SYNTAX Score in Patients With Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention Analysis From the ACUITY (Acute Catheterization and Urgent Intervention Triage StrategY) Trial. Journal Of The American College Of Cardiology 2011, 57: 2389-2397. PMID: 21658558, DOI: 10.1016/j.jacc.2011.02.032.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAngioplasty, Balloon, CoronaryCardiac CatheterizationCoronary AngiographyCoronary Artery BypassElectrocardiographyEmergency TreatmentFemaleHeparin, Low-Molecular-WeightHirudinsHospital MortalityHumansItalyKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisPeptide FragmentsPrognosisProportional Hazards ModelsProspective StudiesRecombinant ProteinsRisk AssessmentROC CurveSeverity of Illness IndexStatistics, NonparametricSurvival AnalysisTreatment OutcomeTriageConceptsSegment elevation acute coronary syndromesElevation acute coronary syndromePercutaneous coronary interventionAcute coronary syndromeSYNTAX scoreCoronary syndromeCardiac deathACUITY trialIndependent predictorsPredictive valueTarget vessel revascularization rateStable ischemic heart diseaseTriple-vessel coronary diseaseVessel revascularization rateCardiac mortality rateMyocardial infarction ratePre-specified subgroupsRisk-stratify patientsIschemic heart diseaseAngiographic substudySS tertilesInfarction rateRevascularization ratesCoronary interventionCoronary diseasePROGNOSTIC UTILITY OF THE SYNTAX SCORE IN PATIENTS WITH SINGLE VS. MULTIVESSEL DISEASE UNDERGOING PERCUTANEOUS CORONARY INTERVENTION: INSIGHTS FROM THE ACUITY TRIAL
Caixeta A, Palmerini T, Genereux P, Cristea E, Lansky A, Mehran R, Dangas G, Corral M, Jankovic I, Lazar D, Sanchez R, Fahy M, Xu K, Stone G. PROGNOSTIC UTILITY OF THE SYNTAX SCORE IN PATIENTS WITH SINGLE VS. MULTIVESSEL DISEASE UNDERGOING PERCUTANEOUS CORONARY INTERVENTION: INSIGHTS FROM THE ACUITY TRIAL. Journal Of The American College Of Cardiology 2011, 57: e1773. DOI: 10.1016/s0735-1097(11)61773-7.Peer-Reviewed Original ResearchPROGNOSTIC UTILITY OF MYOCARDIAL BLUSH GRADE AFTER PCI IN PATIENTS WITH NSTEMI: ANALYSIS FROM THE ACUITY TRIAL
Lansky A, Ng V, Cristea E, Mehran R, Fahy M, Stone G. PROGNOSTIC UTILITY OF MYOCARDIAL BLUSH GRADE AFTER PCI IN PATIENTS WITH NSTEMI: ANALYSIS FROM THE ACUITY TRIAL. Journal Of The American College Of Cardiology 2011, 57: e1772. DOI: 10.1016/s0735-1097(11)61772-5.Peer-Reviewed Original ResearchPROGNOSTIC UTILITY OF PRE-PROCEDURAL TIMI FLOW IN PATIENTS WITH NON ST-SEGMENT ELEVATION ACUTE CORONARY SYNDROMES UNDERGOING PERCUTANEOUS CORONARY REVASCULARIZATION: THE ACUITY TRIAL
De Luca G, Brener S, Mehran R, Lansky A, Cristea E, Fahy M, Stone G. PROGNOSTIC UTILITY OF PRE-PROCEDURAL TIMI FLOW IN PATIENTS WITH NON ST-SEGMENT ELEVATION ACUTE CORONARY SYNDROMES UNDERGOING PERCUTANEOUS CORONARY REVASCULARIZATION: THE ACUITY TRIAL. Journal Of The American College Of Cardiology 2011, 57: e1649. DOI: 10.1016/s0735-1097(11)61649-5.Peer-Reviewed Original ResearchCOMPARISON OF THE PROGNOSTIC UTILITY OF VARIOUS CLINICAL AND ANGIOGRAPHIC RISK SCORES IN PATIENTS WITH ACUTE CORONARY SYNDROMES: ANALYSIS FROM THE ACUITY TRIAL
Palmerini T, Caixeta A, Genereux P, Cristea E, Lansky A, Mehran R, Dangas G, Lazar D, Sanchez R, Corral M, Jankovic I, Fahy M, Xu K, Stone G. COMPARISON OF THE PROGNOSTIC UTILITY OF VARIOUS CLINICAL AND ANGIOGRAPHIC RISK SCORES IN PATIENTS WITH ACUTE CORONARY SYNDROMES: ANALYSIS FROM THE ACUITY TRIAL. Journal Of The American College Of Cardiology 2011, 57: e1106. DOI: 10.1016/s0735-1097(11)61106-6.Peer-Reviewed Original ResearchIncidence and clinical consequences of acquired thrombocytopenia after antithrombotic therapies in patients with acute coronary syndromes: Results from the Acute Catheterization and Urgent Intervention Triage Strategy (ACUITY) trial
Caixeta A, Dangas GD, Mehran R, Feit F, Nikolsky E, Lansky AJ, Aoki J, Moses JW, Steinhubl SR, White HD, Ohman EM, Manoukian SV, Fahy M, Stone GW. Incidence and clinical consequences of acquired thrombocytopenia after antithrombotic therapies in patients with acute coronary syndromes: Results from the Acute Catheterization and Urgent Intervention Triage Strategy (ACUITY) trial. American Heart Journal 2011, 161: 298-306.e1. PMID: 21315212, DOI: 10.1016/j.ahj.2010.10.035.Peer-Reviewed Original ResearchConceptsIIb/IIIa inhibitorsGP IIb/IIIa inhibitorsAcute coronary syndromeBivalirudin monotherapyMajor bleedingCoronary syndromePlatelet countClinical consequencesUrgent Intervention Triage Strategy (ACUITY) trialGlycoprotein IIb/IIIa inhibitorsPredictors of mortalityAcquired thrombocytopeniaACUITY trialAcute CatheterizationAntiplatelet medicationsAntithrombotic therapyIschemic complicationsAnticoagulant regimenIndependent predictorsStrategy trialThrombocytopeniaPatientsMultivariate analysisMonotherapyLess decline