Biodistribution and Radiation Dosimetry of LMI1195: First-in-Human Study of a Novel 18F-Labeled Tracer for Imaging Myocardial Innervation
Sinusas AJ, Lazewatsky J, Brunetti J, Heller G, Srivastava A, Liu YH, Sparks R, Puretskiy A, Lin SF, Crane P, Carson RE, Lee LV. Biodistribution and Radiation Dosimetry of LMI1195: First-in-Human Study of a Novel 18F-Labeled Tracer for Imaging Myocardial Innervation. Journal Of Nuclear Medicine 2014, 55: 1445-1451. PMID: 24994931, DOI: 10.2967/jnumed.114.140137.Peer-Reviewed Original ResearchMeSH KeywordsAdultFemaleFluorine RadioisotopesFluorobenzenesGuanidinesHeartHumansMaleRadiometryRadionuclide ImagingRadiopharmaceuticalsTissue DistributionConceptsAdministered activityBlood-pool standardized uptake valuesPhase 1 clinical trialCardiac nerve terminalsCardiac imagingMSv/MBqMean effective doseStandardized uptake valueRadiation doseOLINDA/EXMPatient radiation doseRadiation dose estimatesAdverse eventsBlood pressureWhole-body imagesClinical trialsBlood radioactivityMyocardial innervationNerve terminalsUrinary bladderHealthy subjectsLiver ratioHeart rateLung activityMyocardial uptake