2023
Multiaxial pressure-strain analysis of regional myocardial work in the setting of graded coronary stenoses and dobutamine stress
Stendahl J, Liu Z, Boutagy N, Parajuli N, Lu A, Alkhalil I, Lin B, Duncan J, Sinusas A. Multiaxial pressure-strain analysis of regional myocardial work in the setting of graded coronary stenoses and dobutamine stress. AJP Heart And Circulatory Physiology 2023, 325: h492-h509. PMID: 37417870, PMCID: PMC10538990, DOI: 10.1152/ajpheart.00735.2022.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCoronary CirculationCoronary StenosisDobutamineDogsHeartMyocardial ContractionMyocardial IschemiaMyocardiumConceptsLow-dose dobutaminePressure-strain loopsCoronary stenosisMyocardial workRegional myocardial workPressure-strain analysisDobutamine stressBlood flowLow-dose dobutamine stressInvasive hemodynamic monitoringMid-left anteriorLow cardiac outputRegional myocardial blood flowCoronary blood flowIschemic heart diseasePresence of ischemiaMyocardial work indexModerate coronary stenosisMyocardial blood flowOpen-chest modelEjection of bloodInotropic supportPressure-strain relationshipHemodynamic monitoringCardiac outputThe Association Between Obstructive Sleep Apnea and Abnormal 82Rubidium Cardiac PET Perfusion Myocardial Flow Reserve
Aneni E, Thorn S, Feher A, Hong Chen J, Sinusas A, Yaggi H, Miller E. The Association Between Obstructive Sleep Apnea and Abnormal 82Rubidium Cardiac PET Perfusion Myocardial Flow Reserve. JACC Cardiovascular Imaging 2023, 16: 856-858. PMID: 36881426, PMCID: PMC10718199, DOI: 10.1016/j.jcmg.2022.11.024.Peer-Reviewed Original Research
2019
Application of Hybrid Matrix Metalloproteinase-Targeted and Dynamic 201Tl Single-Photon Emission Computed Tomography/Computed Tomography Imaging for Evaluation of Early Post-Myocardial Infarction Remodeling
Thorn SL, Barlow SC, Feher A, Stacy MR, Doviak H, Jacobs J, Zellars K, Renaud JM, Klein R, deKemp RA, Khakoo AY, Lee T, Spinale FG, Sinusas AJ. Application of Hybrid Matrix Metalloproteinase-Targeted and Dynamic 201Tl Single-Photon Emission Computed Tomography/Computed Tomography Imaging for Evaluation of Early Post-Myocardial Infarction Remodeling. Circulation Cardiovascular Imaging 2019, 12: e009055. PMID: 31707811, PMCID: PMC7250243, DOI: 10.1161/circimaging.119.009055.Peer-Reviewed Original ResearchConceptsMyocardial blood flowSingle photon emissionBlood flowRecombinant TIMP-3Matrix metalloproteinasesR injuryTomography/Intracoronary deliveryMMP activationPost-myocardial infarction remodelingSubsequent left ventricular remodelingHybrid single-photon emissionDual-isotope single-photon emissionTomography/Computed Tomography ImagingLeft ventricular remodelingIschemia/reperfusionPost-MI remodelingPost-myocardial infarctionComputed tomography (CT) imagingIntracoronary infusionVentricular functionSaline groupVentricular remodelingNoninvasive evaluationTreatment groups
2016
High-Sensitivity and High-Resolution SPECT/CT Systems Provide Substantial Dose Reduction Without Compromising Quantitative Precision for Assessment of Myocardial Perfusion and Function
Palyo RJ, Sinusas A, Liu YH. High-Sensitivity and High-Resolution SPECT/CT Systems Provide Substantial Dose Reduction Without Compromising Quantitative Precision for Assessment of Myocardial Perfusion and Function. Journal Of Nuclear Medicine 2016, 57: 893-899. PMID: 26848173, DOI: 10.2967/jnumed.115.164632.Peer-Reviewed Original ResearchConceptsMyocardial perfusion SPECTEjection fractionDose reductionMyocardial perfusionAnterior descendingRight coronary artery territoryTetrofosmin myocardial perfusion SPECTNormal MPS resultsNuclear Cardiology guidelinesCoronary artery territoryLarge perfusion defectsLV ejection fractionLeft anterior descendingData of patientsNormal myocardial perfusionEnd-systolic volumeRelative dose reductionDefect sizeMPS resultsShort imaging protocolsTetrofosmin scanArtery territoryCardiology guidelinesSubstantial dose reductionLV function
2001
Does contrast echocardiography provide new insight regarding regulation of microcirculatory flow and stress perfusion imaging?
Sinusas A, Kailasnath P. Does contrast echocardiography provide new insight regarding regulation of microcirculatory flow and stress perfusion imaging? Journal Of Nuclear Cardiology 2001, 8: 707-710. PMID: 11725268, DOI: 10.1067/mnc.2001.120368.Peer-Reviewed Original ResearchMeSH KeywordsCapillariesCoronary CirculationEchocardiographyHumansHyperemiaMicrocirculationStress, PhysiologicalEstimation of coronary flow reserve: Can SPECT compete with other modalities?
Gullberg G, Di Bella E, Sinusas A. Estimation of coronary flow reserve: Can SPECT compete with other modalities? Journal Of Nuclear Cardiology 2001, 8: 620-625. PMID: 11593228, DOI: 10.1067/mnc.2001.118121.Peer-Reviewed Original ResearchComparison of Tl-201 with Tc-99m–labeled myocardial perfusion agents: Technical, physiologic, and clinical issues
Kailasnath P, Sinusas A. Comparison of Tl-201 with Tc-99m–labeled myocardial perfusion agents: Technical, physiologic, and clinical issues. Journal Of Nuclear Cardiology 2001, 8: 482-498. PMID: 11481571, DOI: 10.1067/mnc.2001.115078.Peer-Reviewed Original ResearchTechnetium-99m-labeled Myocardial Perfusion Agents: Are They Better than Thallium-201?
Kailasnath P, Sinusas A. Technetium-99m-labeled Myocardial Perfusion Agents: Are They Better than Thallium-201? Cardiology In Review 2001, 9: 160-172. PMID: 11304401, DOI: 10.1097/00045415-200105000-00009.Peer-Reviewed Original ResearchMeSH KeywordsCoronary CirculationHumansMyocardial IschemiaOrganotechnetium CompoundsRadionuclide ImagingThalliumThallium RadioisotopesConceptsCoronary artery diseasePerfusion tracerPerfusion agentArtery diseaseMyocardial viabilityThallium-201Perfusion imagingMyocardial perfusion imagingRegional flow heterogeneityPharmacologic stressorChest painMyocardial perfusion agentRisk stratificationAcute assessmentNew perfusion agentTechnetium-99mClinical valueMyocardial uptakeIschemic regionAssessment of viabilityCoronary vasculatureMyocardial flowClearance kineticsMyocardial retentionTracer availability
2000
Assessment of left ventricular ejection fraction with quantitative gated SPECT: Accuracy and correlation with first-pass radionuclide angiography
Vallejo E, Dione D, Sinusas A, Wackers F. Assessment of left ventricular ejection fraction with quantitative gated SPECT: Accuracy and correlation with first-pass radionuclide angiography. Journal Of Nuclear Cardiology 2000, 7: 461-470. PMID: 11083195, DOI: 10.1067/mnc.2000.107820.Peer-Reviewed Original ResearchConceptsVentricular ejection fractionEjection fractionPatient studiesLeft ventricular ejection fractionExtracardiac activityFirst-pass radionuclide angiographyLarger end-diastolic volumeStress-induced ischemiaEnd-diastolic volumeQuantitative gated SPECTSingle photon emissionAbnormal LVEFNormal LVEFRadionuclide angiographyDiastolic volumeLVEFPerfusion defectsLVEF valuesSame patientHeart sizeLeft ventricleGated SPECTSPECT studiesQGSMean restAcute ischemic dysfunction alters coronary flow reserve in remote nonischemic regions: Potential mechanical etiology identified in an acute canine model
Daher E, Dione D, Heller E, Holahan J, DeMan P, Shen M, Hu J, Sinusas A. Acute ischemic dysfunction alters coronary flow reserve in remote nonischemic regions: Potential mechanical etiology identified in an acute canine model. Journal Of Nuclear Cardiology 2000, 7: 112-122. PMID: 10796000, DOI: 10.1016/s1071-3581(00)90031-x.Peer-Reviewed Original ResearchConceptsCoronary flow reserveRemote nonischemic regionsProximal occlusionNonischemic regionsThickening fractionCanine modelDistal occlusionCoronary flowIschemic areaFlow reserveMechanical etiologyLeft ventricleLeft circumflex artery regionAnterior descending (LAD) coronary artery occlusionProgressive decreaseAnesthetized open-chest canine modelCoronary artery occlusionExtent of ischemiaGlobal hemodynamic parametersProximal coronary occlusionRegional ischemic dysfunctionAcute canine modelImportant clinical implicationsOpen-chest canine modelMicrosphere blood flowSevere regional ischemia alters coronary flow reserve in the remote perfusion area
Wu J, Yun J, Dione D, Heller E, Deckelbaum L, Sinusas A. Severe regional ischemia alters coronary flow reserve in the remote perfusion area. Journal Of Nuclear Cardiology 2000, 7: 43-52. PMID: 10698234, DOI: 10.1067/mnc.2000.99189.Peer-Reviewed Original ResearchConceptsLAD coronary flow reserveCoronary flow reserveLCX stenosisFlow reserveImpairment of CFRStenosis severityRemote nonischemic regionsRate-pressure productRegional myocardial dysfunctionDoppler flow probesTransstenotic pressure gradientOpen-chest dogsAcute canine modelIschemic dysfunctionAnterior descendingIntracoronary injectionMyocardial dysfunctionProximal LCXCoronary stenosisMyocardial infarctionAcute ischemiaProgressive impairmentPerfusion areaRegional myocardial flowTransstenotic gradient
1999
Quantification of SPECT myocardial perfusion images: Methodology and validation of the Yale-CQ method
Liu Y, Sinusas A, DeMan P, Zaret B, Wackers F. Quantification of SPECT myocardial perfusion images: Methodology and validation of the Yale-CQ method. Journal Of Nuclear Cardiology 1999, 6: 190-203. PMID: 10327104, DOI: 10.1016/s1071-3581(99)90080-6.Peer-Reviewed Original Research
1996
Quantification of technetium 99m-labeled sestamibi single-photon emission computed tomography based on mean counts improves accuracy for assessment of relative regional myocardial blood flow: Experimental validation in a canine model
Liu Y, Sinusas A, Shi C, Shen M, Dione D, Heller E, Wackers F. Quantification of technetium 99m-labeled sestamibi single-photon emission computed tomography based on mean counts improves accuracy for assessment of relative regional myocardial blood flow: Experimental validation in a canine model. Journal Of Nuclear Cardiology 1996, 3: 312-320. PMID: 8799250, DOI: 10.1016/s1071-3581(96)90091-4.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCoronary CirculationDogsHeartTechnetium Tc 99m SestamibiTomography, Emission-Computed, Single-PhotonConceptsMyocardial blood flowRelative blood flowRelative myocardial blood flowRegional myocardial blood flowCoronary artery occlusionBlood flowSingle photon emissionArtery occlusionCanine modelShort-axis slicesEx vivoSestamibi single-photon emissionMyocardial countsFlow deficitsMyocardial count densityNormal blood flowMean countsRegional myocardial perfusionCount profilesMIBI uptakeMIBI SPECTSestamibi SPECTMyocardial perfusionCircumferential count profilesRelative regional myocardial blood flowAssessment of reperfusion after acute myocardial infarction: Is there a role for acute technetium 99m-teboroxime imaging?
Sinusas A. Assessment of reperfusion after acute myocardial infarction: Is there a role for acute technetium 99m-teboroxime imaging? Journal Of Nuclear Cardiology 1996, 3: 82-85. PMID: 8799231, DOI: 10.1016/s1071-3581(96)90027-6.Peer-Reviewed Original Research
1989
Effect of ischemia and postischemic dysfunction on myocardial uptake of technetium-99m-labeled methoxyisobutyl isonitrile and thallium-201
Sinusas A, Watson D, Cannon J, Beller G. Effect of ischemia and postischemic dysfunction on myocardial uptake of technetium-99m-labeled methoxyisobutyl isonitrile and thallium-201. Journal Of The American College Of Cardiology 1989, 14: 1785-1793. PMID: 2584570, DOI: 10.1016/0735-1097(89)90034-x.Peer-Reviewed Original ResearchConceptsLow coronary flowThallium-201Postischemic dysfunctionMyocardial uptakeArtery occlusionMethoxyisobutyl isonitrileEndocardial flowCoronary flowGroup II dogsTwo-dimensional echocardiographyEffects of ischemiaRegional blood flowOpen-chest canine modelMyocardial perfusion agentEpicardial segmentsRadionuclide injectionBlood flowEndocardial segmentsRegional dysfunctionIschemic regionLeft ventricleCanine modelDysfunctionGroup IPerfusion agent