2019
Noninvasive In Vivo Quantification of Adeno-Associated Virus Serotype 9–Mediated Expression of the Sodium/Iodide Symporter Under Hindlimb Ischemia and Neuraminidase Desialylation in Skeletal Muscle Using Single-Photon Emission Computed Tomography/Computed Tomography
Boutagy NE, Ravera S, Papademetris X, Onofrey JA, Zhuang ZW, Wu J, Feher A, Stacy MR, French BA, Annex BH, Carrasco N, Sinusas AJ. Noninvasive In Vivo Quantification of Adeno-Associated Virus Serotype 9–Mediated Expression of the Sodium/Iodide Symporter Under Hindlimb Ischemia and Neuraminidase Desialylation in Skeletal Muscle Using Single-Photon Emission Computed Tomography/Computed Tomography. Circulation Cardiovascular Imaging 2019, 12: e009063. PMID: 31296047, PMCID: PMC6629470, DOI: 10.1161/circimaging.119.009063.Peer-Reviewed Original ResearchConceptsMicro-single photon emissionSingle photon emissionHindlimb ischemiaTomography/Tomography/Computed TomographyIschemic gastrocnemius muscleNIS inhibitor perchloratePeripheral artery diseaseSkeletal muscleUnilateral hindlimb ischemiaAdeno-Associated Virus Serotype 9Standardized uptake valueSodium/iodide symporterVivo quantificationVirus serotype 9Vivo validationNonischemic limbsArtery diseaseNonischemic muscleC57BL/6J miceMurine modelGastrocnemius muscleComputed tomographyIschemic conditionsRadiotracer uptake
2004
Evaluation of myocardial matrix metalloproteinase (MMP) mediated post-MI remodeling with a novel radiolabeled MMP inhibitor
Su H, Spinale F, Dobrucki1 L, Chow C, Sweterlitsch S, Hu X, Bourke B, Cavaliere P, Hua J, Azure M, Edwards D, Sinusas A. Evaluation of myocardial matrix metalloproteinase (MMP) mediated post-MI remodeling with a novel radiolabeled MMP inhibitor. Journal Of Nuclear Cardiology 2004, 11: s20. DOI: 10.1016/j.nuclcard.2004.06.063.Peer-Reviewed Original ResearchMyocardial infarctionPost-MI remodelingPost-myocardial infarctionMMP activationMMP inhibitorsControl groupSitu zymographyMyocardial matrix metalloproteinasesMI regionMin post injectionControl miceMI miceVentricular remodelingPost-MIMI groupMurine modelNew therapiesMatrix metalloproteinaseMMP activityMatrix metalloproteinasesShort-axis slicesMI areaPost injectionMyocardial retentionMice