2024
The Updated Registry of Fast Myocardial Perfusion Imaging with Next-Generation SPECT (REFINE SPECT 2.0).
Miller R, Lemley M, Shanbhag A, Ramirez G, Liang J, Builoff V, Kavanagh P, Sharir T, Hauser M, Ruddy T, Fish M, Bateman T, Acampa W, Einstein A, Dorbala S, Di Carli M, Feher A, Miller E, Sinusas A, Halcox J, Martins M, Kaufmann P, Dey D, Berman D, Slomka P. The Updated Registry of Fast Myocardial Perfusion Imaging with Next-Generation SPECT (REFINE SPECT 2.0). Journal Of Nuclear Medicine 2024, 65: 1795-1801. PMID: 39362762, PMCID: PMC11533915, DOI: 10.2967/jnumed.124.268292.Peer-Reviewed Original ResearchCoronary artery calciumCT attenuation correction imagesStress total perfusion deficitMyocardial perfusion imagingTotal perfusion deficitAttenuation correction imagesPerfusion imagingREFINE SPECTImprove prediction of adverse outcomesPerfusion deficitsSPECT myocardial perfusion imagingIncreased risk of MACEPredictive of adverse outcomesMedian follow-upInvasive coronary angiographyRisk of MACEAdverse cardiovascular eventsCAC scoreExperience MACECoronary angiographyArtery calciumInternational registryCardiovascular eventsFollow-upClinical dataAssociation between 82Rb positron emission tomography-derived regional myocardial blood flow, severity of angiographic coronary artery stenosis, and mortality in patients with chest pain
Gallegos C, Paredes C, Hu J, Posada E, Saito Y, Lansky A, Shah S, Liu Y, Smolderen K, Mena-Hurtado C, Sinusas A, Miller E. Association between 82Rb positron emission tomography-derived regional myocardial blood flow, severity of angiographic coronary artery stenosis, and mortality in patients with chest pain. Advances In Radiotherapy & Nuclear Medicine 2024, 2: 3786. DOI: 10.36922/arnm.3786.Peer-Reviewed Original ResearchMyocardial flow reserveGlobal myocardial flow reserveQuantitative coronary angiographyAssociated with increased all-cause mortalityPositron emission tomographyCoronary artery stenosis severityMyocardial blood flowAll-cause mortalityCoronary angiographyChest painStenosis severityAngiographic coronary artery stenosisResting myocardial blood flowAcute chest painBlood flowInvasive coronary angiographyLeft circumflex arteryLeft descending arteryRight coronary arteryCoronary artery stenosisStress testCoronary stenosis severityCardiovascular eventsDescending arteryWeak correlation
2023
Comparison of the prognostic value between quantification and visual estimation of coronary calcification from attenuation CT in patients undergoing SPECT myocardial perfusion imaging
Feher A, Pieszko K, Shanbhag A, Lemley M, Miller R, Huang C, Miras L, Liu Y, Gerber J, Sinusas A, Miller E, Slomka P. Comparison of the prognostic value between quantification and visual estimation of coronary calcification from attenuation CT in patients undergoing SPECT myocardial perfusion imaging. The International Journal Of Cardiovascular Imaging 2023, 40: 185-193. PMID: 37845406, PMCID: PMC466934, DOI: 10.1007/s10554-023-02980-1.Peer-Reviewed Original ResearchConceptsMajor adverse cardiovascular eventsCoronary artery calcificationMyocardial perfusion imagingCT myocardial perfusion imagingSPECT/CT myocardial perfusion imagingArtery calcificationPrognostic valuePrior coronary stentingAdverse cardiovascular eventsSimilar prognostic valueSPECT myocardial perfusionREFINE SPECT registrySPECT/CTCardiovascular eventsCAC scoringCalcium scoreCoronary calcificationCoronary stentingPrognostic utilitySingle centerCoronary arteryLow doseMyocardial perfusionPerfusion imagingSurvival analysisTime and event-specific deep learning for personalized risk assessment after cardiac perfusion imaging
Pieszko K, Shanbhag A, Singh A, Hauser M, Miller R, Liang J, Motwani M, Kwieciński J, Sharir T, Einstein A, Fish M, Ruddy T, Kaufmann P, Sinusas A, Miller E, Bateman T, Dorbala S, Di Carli M, Berman D, Dey D, Slomka P. Time and event-specific deep learning for personalized risk assessment after cardiac perfusion imaging. Npj Digital Medicine 2023, 6: 78. PMID: 37127660, PMCID: PMC10151323, DOI: 10.1038/s41746-023-00806-x.Peer-Reviewed Original ResearchAcute coronary syndromeMajor adverse cardiovascular eventsMyocardial perfusion imagingCause deathAdverse cardiovascular eventsModifiable risk factorsPrediction of deathPersonalized risk assessmentCardiovascular eventsCoronary syndromeClinical featuresPrognostic valueRisk factorsExternal cohortStandard clinical interpretationPerfusion imagingAbnormality measuresCardiac perfusionTime pointsPatients' explanationsClinical interpretationExternal validationDeathPatientsRisk assessmentCorrection to: Integration of coronary artery calcium scoring from CT attenuation scans by machine learning improves prediction of adverse cardiovascular events in patients undergoing SPECT/CT myocardial perfusion imaging
Feher A, Pieszko K, Miller R, Lemley M, Shanbhag A, Huang C, Miras L, Liu Y, Sinusas A, Miller E, Slomka P. Correction to: Integration of coronary artery calcium scoring from CT attenuation scans by machine learning improves prediction of adverse cardiovascular events in patients undergoing SPECT/CT myocardial perfusion imaging. Journal Of Nuclear Cardiology 2023, 30: 860-863. PMID: 36598750, DOI: 10.1007/s12350-022-03196-x.Peer-Reviewed Original Research
2020
Coronary Computed Tomography Angiography Compared With Single Photon Emission Computed Tomography Myocardial Perfusion Imaging as a Guide to Optimal Medical Therapy in Patients Presenting With Stable Angina: The RESCUE Trial
Stillman A, Gatsonis C, Lima J, Liu T, Snyder B, Cormack J, Malholtra V, Schnall M, Udelson J, Hoffmann U, Woodard P, Kim M, Hegde V, Kenny, Afaq M, Clouse M, Malhotra V, Cole, Al‐Khori F, Scherer M, Rothenberg F, Kirsch J, Shah A, Quyyumi A, Engberding N, Becker C, Li D, Pantelic M, Duerinckx A, Martin, Schrank J, Zachariah, Jacob R, Borges A, Roberge E, Truong Q, Edelman R, Akers S, Marsh K, Kemp, Reingold J, Chilakapati V, Osborne J, Lui K, Gomes A, Bajpai A, del Rio J, Singh, Thompson B, Rivard A, Jha S, Mavromatis K, Woodard P, Sinusas A. Coronary Computed Tomography Angiography Compared With Single Photon Emission Computed Tomography Myocardial Perfusion Imaging as a Guide to Optimal Medical Therapy in Patients Presenting With Stable Angina: The RESCUE Trial. Journal Of The American Heart Association 2020, 9: e017993. PMID: 33283579, PMCID: PMC7955393, DOI: 10.1161/jaha.120.017993.Peer-Reviewed Original ResearchConceptsMajor adverse cardiovascular eventsOptimal medical therapyAcute myocardial infarctionMedical therapyStable anginaMyocardial perfusion imagingMyocardial infarctionSingle photon emissionNegative CCTAHazard ratioRescue trialPerfusion imagingFirst major adverse cardiovascular eventTomography myocardial perfusion imagingSPECT myocardial perfusion imagingAdverse cardiovascular eventsOutcomes of patientsTomography myocardial perfusionFirst imaging testPhoton emissionCCTA armPositive CCTACardiovascular eventsSegment involvementOutcome trials
2019
TRANSIENT ISCHEMIC DILATATION IS INDEPENDENTLY ASSOCIATED WITH INCREASED CARDIOVASCULAR EVENTS IN PATIENTS WITHOUT ISCHEMIA: ANALYSIS OF THE REFINE REGISTRY
Miller R, Hu L, Gransar H, Betancur J, Eisenberg E, Sharir T, Fish M, Ruddy T, Dorbala S, Di Carli M, Einstein A, Kaufmann P, Sinusas A, Miller E, Bateman T, Tamarappoo B, Dey D, Berman D, Slomka P. TRANSIENT ISCHEMIC DILATATION IS INDEPENDENTLY ASSOCIATED WITH INCREASED CARDIOVASCULAR EVENTS IN PATIENTS WITHOUT ISCHEMIA: ANALYSIS OF THE REFINE REGISTRY. Journal Of The American College Of Cardiology 2019, 73: 1454. DOI: 10.1016/s0735-1097(19)32060-1.Peer-Reviewed Original Research