Induction of Ig light chain gene rearrangement in heavy chain-deficient B cells by activated Ras
Shaw A, Swat W, Davidson L, Alt F. Induction of Ig light chain gene rearrangement in heavy chain-deficient B cells by activated Ras. Proceedings Of The National Academy Of Sciences Of The United States Of America 1999, 96: 2239-2243. PMID: 10051625, PMCID: PMC26767, DOI: 10.1073/pnas.96.5.2239.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsB-LymphocytesBase SequenceBlastocystCell DifferentiationDNA-Binding ProteinsEmbryo, MammalianGene Rearrangement, B-Lymphocyte, Light ChainGenes, ImmunoglobulinImmunoglobulin Heavy ChainsImmunoglobulin kappa-ChainsImmunoglobulin Light ChainsImmunoglobulin Variable RegionKidneyMiceMolecular Sequence DataRas ProteinsRecombinant Fusion ProteinsSignal TransductionSpleenStem CellsTransfectionConceptsRas expressionVariable region gene assemblyEmbryonic stem cellsIg light chain gene rearrangementGene rearrangementsB cell developmentWild-type B cellsB lineage cellsLight chain gene rearrangementsDevelopmental checkpointsHeavy chain geneGene productsGene assemblyExpression constructsB cell differentiationGene expressionBlastocyst complementationIg heavy chain genesCell developmentCell differentiationVariable region genesB cellsDifferentiation potentialLineage cellsChain geneActivated Ras Signals Developmental Progression of Recombinase-activating Gene (RAG)-deficient Pro-B Lymphocytes
Shaw A, Swat W, Ferrini R, Davidson L, Alt F. Activated Ras Signals Developmental Progression of Recombinase-activating Gene (RAG)-deficient Pro-B Lymphocytes. Journal Of Experimental Medicine 1999, 189: 123-129. PMID: 9874569, PMCID: PMC1887686, DOI: 10.1084/jem.189.1.123.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsB-LymphocytesCell DifferentiationCell SurvivalDNA-Binding ProteinsEnzyme ActivationGene Expression Regulation, DevelopmentalGenes, RAG-1Immunoglobulin Heavy ChainsImmunoglobulin kappa-ChainsMiceMice, KnockoutPhenotypeRas ProteinsRNA, MessengerStem CellsTranscription, GeneticUp-RegulationConceptsB cellsRAG-deficient backgroundPeripheral lymphoid tissuesB-cell lineageEarly B cell developmentB lineage cellsLymphoid tissueBcl-2 transgeneCD43 expressionRecombination-activating gene 1B cell developmentHeavy chain transgeneSurface markersB cell stageLineage cellsIntracellular pathwaysMature B-cell stageDeficient backgroundProgressionGene 1Survival signalsCell developmentOverall phenotypeResult of expressionCell lineages