Cytoplasmic tail deletion converts membrane immunoglobulin to a phosphatidylinositol-linked form lacking signaling and efficient antigen internalization functions
Mitchell RN, Shaw AC, Weaver YK, Leder P, Abbas AK. Cytoplasmic tail deletion converts membrane immunoglobulin to a phosphatidylinositol-linked form lacking signaling and efficient antigen internalization functions. Journal Of Biological Chemistry 1991, 266: 8856-8860. PMID: 2026599, DOI: 10.1016/s0021-9258(18)31524-2.Peer-Reviewed Original ResearchConceptsPhosphatidylinositol-linked formSignal transduction functionsPhosphatidylinositol-linked proteinsB cell lymphoma A20Cytoplasmic domainCytoplasmic tailMembrane proteinsSignal transductionTransmembrane proteinTransmembrane residuesTransduction functionMolecular massInternalization functionProteinAntigen receptorAntigen presentationEarly eventsMembrane immunoglobulinIg moleculesMode of expressionTransductionMIgMB lymphocytesSignalingResidues