1990
Mutations of immunoglobulin transmembrane and cytoplasmic domains: Effects on intracellular signaling and antigen presentation
Shaw A, Mitchell R, Weaver Y, Campos-Torres J, Abbas A, Leder P. Mutations of immunoglobulin transmembrane and cytoplasmic domains: Effects on intracellular signaling and antigen presentation. Cell 1990, 63: 381-392. PMID: 2119890, DOI: 10.1016/0092-8674(90)90171-a.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntibody FormationAntigensBase SequenceB-LymphocytesCalciumCell LineCell MembraneCytoplasmHumansImmunoglobulin mu-ChainsKineticsMiceMolecular Sequence DataMutagenesis, Site-DirectedOligonucleotide ProbesReceptors, Antigen, B-CellSequence Homology, Nucleic AcidSignal TransductionTransfectionConceptsCytoplasmic domainSignal transductionShort cytoplasmic domainDifferent protein interactionsMembrane-bound formMu chain geneProtein interactionsTransmembrane residuesIntracellular signalingChain geneSpecific mutationsTransductionAntigen presentationAntigen-specific receptorsMutationsTransmembraneB cellsGenesSignalingDomainResiduesCellsAssaysReceptors
1987
Allelic Exclusion in Transgenic Mice That Express the Membrane form of Immunoglobulin μ
Nussenzweig M, Shaw A, Sinn E, Danner D, Holmes K, Morse H, Leder P. Allelic Exclusion in Transgenic Mice That Express the Membrane form of Immunoglobulin μ. Science 1987, 236: 816-819. PMID: 3107126, DOI: 10.1126/science.3107126.Peer-Reviewed Original ResearchConceptsMembrane-bound formAllelic exclusionMembrane-bound proteinsMu chainsMu chain geneHeavy chainHeavy chain allelesHuman genesTransgenic miceImmunoglobulin μMessenger RNAMembrane formChain geneAntibody genesB cellsGenesImmunoglobulin M heavy chainHuman mu chainsMouse systemCellsRegulationMolecular formsRNATransgeneProtein