2019
Effects of Aging on Human Toll-Like Receptor Function
Shaw A. Effects of Aging on Human Toll-Like Receptor Function. 2019, 981-992. DOI: 10.1007/978-3-319-99375-1_98.Peer-Reviewed Original ResearchInnate immune pattern recognition receptorsPattern recognition receptorsImmune pattern recognition receptorsToll-like receptorsTLR functionAdaptive immunityImmune systemEndogenous ligandAge-related chronic inflammationToll-like receptor functionT cell responsesInnate immune primingInnate immune systemAge-associated alterationsCombination of alterationsAge-related changesEffect of ageDendritic cellsInflammatory dysregulationChronic inflammationImmune primingRecognition receptorsCell responsesReceptor functionOlder adults
2018
Effects of Aging on Human Toll-Like Receptor Function
Shaw A. Effects of Aging on Human Toll-Like Receptor Function. 2018, 1-12. DOI: 10.1007/978-3-319-64597-1_98-1.Peer-Reviewed Original ResearchInnate immune pattern recognition receptorsPattern recognition receptorsImmune pattern recognition receptorsToll-like receptorsTLR functionAdaptive immunityImmune systemEndogenous ligandAge-related chronic inflammationToll-like receptor functionT cell responsesInnate immune primingInnate immune systemAge-associated alterationsCombination of alterationsAge-related changesEffect of ageDendritic cellsInflammatory dysregulationChronic inflammationImmune primingRecognition receptorsReceptor functionOlder adultsYoung adults
2016
Host Resistance and Immune Aging
Bandaranayake T, Shaw AC. Host Resistance and Immune Aging. Clinics In Geriatric Medicine 2016, 32: 415-432. PMID: 27394014, PMCID: PMC6986475, DOI: 10.1016/j.cger.2016.02.007.Peer-Reviewed Original ResearchConceptsImmune systemImpaired innate immune responseToll-like receptor functionEarly pro-inflammatory responseNeutrophil extracellular trap formationT cell compartmentB cell subsetsPro-inflammatory responseExtracellular trap formationInnate immune responseInnate immune systemAdaptive immune systemHuman immune systemBasal inflammationCytomegalovirus infectionImmune agingCell subsetsImmunologic challengeImmune responseT-lineageReceptor functionOlder adultsFunction altersCell compartmentAge
2014
Aging of the human innate immune system in HIV infection
Zapata HJ, Shaw AC. Aging of the human innate immune system in HIV infection. Current Opinion In Immunology 2014, 29: 127-136. PMID: 24997358, PMCID: PMC4145838, DOI: 10.1016/j.coi.2014.06.007.Peer-Reviewed Original ResearchConceptsHIV infectionHIV-negative adultsChronic inflammatory statePro-inflammatory environmentInnate immune recognitionInnate immune responseInnate immune systemHuman innate immune systemMicrobial translocationImmune agingInflammatory stateImmune responseEndogenous ligandImmune recognitionImmune systemInfectionMultiple factorsEarly stagesHIV
2013
Age-dependent dysregulation of innate immunity
Shaw AC, Goldstein DR, Montgomery RR. Age-dependent dysregulation of innate immunity. Nature Reviews Immunology 2013, 13: 875-887. PMID: 24157572, PMCID: PMC4096436, DOI: 10.1038/nri3547.Peer-Reviewed Original ResearchConceptsMetabolic syndromeIntracellular killingInnate immunityToll-like receptor functionNeutrophil extracellular trap formationBasal cytokine productionInnate immune dysregulationDendritic cell populationsMonocyte-derived DCsChronic viral infectionsMyeloid cells-1Pro-inflammatory milieuChronic inflammatory conditionsInnate immune activationVirus-infected macrophagesExtracellular trap formationAge-dependent dysregulationInnate immune systemPattern recognition receptorsAge-associated alterationsMacrophage colony-stimulating factorGranulocyte/macrophage colony-stimulating factorColony-stimulating factorTLR expressionImmune dysregulation