2023
Molecular Characterization of Leptospira Species Detected in the Kidneys of Slaughtered Livestock in Abattoirs in Gauteng Province, South Africa
Dogonyaro B, van Heerden H, Potts A, Fasina F, Casanovas-Massana A, Kolo F, Lötter C, Byaruhanga C, Ko A, Wunder E, Adesiyun A. Molecular Characterization of Leptospira Species Detected in the Kidneys of Slaughtered Livestock in Abattoirs in Gauteng Province, South Africa. Pathogens 2023, 12: 666. PMID: 37242336, PMCID: PMC10223745, DOI: 10.3390/pathogens12050666.Peer-Reviewed Original ResearchHardjo-bovisQPCR-positive samplesLivestock populationsFirst molecular characterizationLivestockSouth AfricaMolecular characterizationSheepLeptospira speciesGauteng ProvinceCattleMolecular methodsSerovar IcterohaemorrhagiaeBovisSppPigsAfricaGene regionAbattoirProvinceIcterohaemorrhagiaeTreesLeptospirosisQPCRSpecies
2022
Leptospira Infection in Rural Areas of Urabá Region, Colombia: A Prospective Study.
Quintero-Vélez J, Rodas J, Rojas C, Ko A, Wunder E. Leptospira Infection in Rural Areas of Urabá Region, Colombia: A Prospective Study. American Journal Of Tropical Medicine And Hygiene 2022, 107: 1267-1277. PMID: 36375452, PMCID: PMC9768283, DOI: 10.4269/ajtmh.21-1103.Peer-Reviewed Original ResearchConceptsOutdoor occupationsLeptospira infectionProspective studyRisk factorsMultivariable modelLeptospira seroprevalenceLogistic regression modelsEco-epidemiological aspectsMultinomial logistic regression modelsMultivariable analysisSerologic testingPrimary exposureMale genderMicroscopic agglutinationPresence of ratsOlder ageRural areasLeptospira serogroupsInfectionSeroincidenceLeptospira speciesSeroprevalenceSerogroupsRegression modelsDirt floors
2021
A live attenuated-vaccine model confers cross-protective immunity against different species of the Leptospira genus
Wunder EA, Adhikarla H, Hamond C, Bonner K, Liang L, Rodrigues CB, Bisht V, Nally JE, Alt DP, Reis MG, Diggle PJ, Felgner PL, Ko A. A live attenuated-vaccine model confers cross-protective immunity against different species of the Leptospira genus. ELife 2021, 10: e64166. PMID: 33496263, PMCID: PMC7837694, DOI: 10.7554/elife.64166.Peer-Reviewed Original ResearchConceptsCross-protective immunityPathogenic Leptospira speciesTerms of morbidityLeptospira speciesTransient bacteremiaSingle doseAntibody responseImmune responseApplicable vaccinesVaccine candidatesAnimal modelsEffective preventionAttenuated mutantsZoonotic diseaseLeptospira genusPotential correlatesDisease transmissionDiseaseLeptospirosisImmunityBacteremiaMorbidityImmunizationVaccineRelevant proteins