2024
Polypharmacy in elective lumbar spinal surgery for degenerative conditions with 24-month follow-up
Dietz N, Kumar C, Elsamadicy A, Bjurström M, Wong K, Jamieson A, Sharma M, Wang D, Ugiliweneza B, Drazin D, Boakye M. Polypharmacy in elective lumbar spinal surgery for degenerative conditions with 24-month follow-up. Scientific Reports 2024, 14: 25340. PMID: 39455709, PMCID: PMC11511981, DOI: 10.1038/s41598-024-76248-6.Peer-Reviewed Original ResearchConceptsDegenerative lumbar pathologySurgical site infectionSpinal surgeryPolypharmacy groupSite infectionLumbar pathologyFollow-upMedical complicationsElective lumbar spinal surgeryLumbar spinal surgeryUrinary tract infectionDegenerative lumbar conditionsReturn to the emergency departmentTract infectionsNon-polypharmacy groupSurgical patientsLumbar conditionsSurgeryPatientsComplicationsPolypharmacyEmergency departmentPrescribed medicationsMarketScan datasetDegenerative conditionsEffect of cannabis use history on postoperative opioid utilization in lumbar fusion patients: an American retrospective study.
Mirpuri P, Khalid S, King P, Roy J, Elsamadicy A, Mehta A, Adogwa O. Effect of cannabis use history on postoperative opioid utilization in lumbar fusion patients: an American retrospective study. Asian Spine Journal 2024, 18: 639-646. PMID: 39434224, DOI: 10.31616/asj.2024.0194.Peer-Reviewed Original ResearchCannabis use historyPostoperative opioid utilizationOpioid utilizationCannabis usersLumbar fusionHistory of cannabis useChronic opioid useNon-cannabis usersDegenerative spine diseaseCannabis use patternsImmediate postoperative periodPostsurgical pain managementLumbar fusion patientsPropensity score matchingUse historyOpioid useSpine surgeryPain medicationFusion patientsRetrospective studySpine diseasePostoperative periodCannabis usePain managementWidespread prescriptionUtility of Risk Analysis Index for Assessing Morbidity in Patients Undergoing Posterior Spinal Fusion for Adult Spinal Deformity
Elsamadicy A, Sadeghzadeh S, Serrato P, Sayeed S, Hengartner A, Belkasim S, Khalid S, Lo S, Sciubba D. Utility of Risk Analysis Index for Assessing Morbidity in Patients Undergoing Posterior Spinal Fusion for Adult Spinal Deformity. World Neurosurgery 2024 PMID: 39321916, DOI: 10.1016/j.wneu.2024.09.089.Peer-Reviewed Original ResearchPosterior spinal fusionAdult spinal deformityRisk Analysis IndexLength of stayMFI-5Spinal fusionReceiver operating characteristicSpinal deformityFrail patientsMultivariate analysisModified 5-item frailty indexACS NSQIP databasePreoperative surgical planningRetrospective cohort studyNSQIP databasePatient ageAssess morbidityComplication riskPredicting 30-day readmissionCohort studySurgical planningNormal patientsAdvanced ageComplicationsPatientsLumbocaval Shunt for Idiopathic Intracranial Hypertension: A Technical Report and Case Series
Sujijantarat N, Koo A, Elsamadicy A, Antonios J, Renedo D, Haynes J, Fathima B, Theriault B, Chavez M, Amllay A, Nowicki K, Kanzler M, Jiang J, Shekar A, Hebert R, DiLuna M, Matouk C. Lumbocaval Shunt for Idiopathic Intracranial Hypertension: A Technical Report and Case Series. Neurosurgery Open 2024, 5: e00113. DOI: 10.1227/neuprac.0000000000000113.Peer-Reviewed Original ResearchIdiopathic intracranial hypertensionIntracranial hypertensionTreatment of idiopathic intracranial hypertensionManagement of idiopathic intracranial hypertensionMedical records of patientsAssessment of long-term outcomesHigh-pressure headachesMedian operative timeDifficult-to-manage patientsLow-pressure headacheCerebrospinal fluid shuntsElectronic medical records of patientsRecords of patientsFollow-up visitLong-term outcomesLumbar shuntDifficult-to-manage casesIntraoperative complicationsShunt revisionImprove headacheCase seriesEarly outcomesSurgical techniqueNeurosurgical managementOperative timeHigh inpatient-opioid consumption predicts extended length of hospital stay in patients undergoing spinal fusion for adolescent idiopathic scoliosis
Sandhu M, Craft S, Reeves B, Sayeed S, Hengartner A, Tuason D, DiLuna M, Elsamadicy A. High inpatient-opioid consumption predicts extended length of hospital stay in patients undergoing spinal fusion for adolescent idiopathic scoliosis. Spine Deformity 2024, 1-11. PMID: 39320702, DOI: 10.1007/s43390-024-00960-6.Peer-Reviewed Original ResearchLength of hospital stayPosterior spinal fusionAdolescent idiopathic scoliosisProportion of patientsAdverse eventsCost of admissionHospital stayIdiopathic scoliosisSpinal fusionMethodsA retrospective cohort studyLogistic multivariate regression analysisIncreased 30-day readmission ratePost-operative adverse eventsExtended length of hospital stayHospital length of stayReadmission ratesPost-operative analgesiaRetrospective cohort studyPremier Healthcare DatabaseHigh cohortPerioperative adverse eventsMultivariate regression analysisIncreased cost of admissionLength of staySpine surgeryAssessing a revised-risk analysis index for morbidity and mortality after spine surgery for metastatic spinal tumors
Elsamadicy A, Serrato P, Sadeghzadeh S, Sayeed S, Hengartner A, Khalid S, Lo S, Shin J, Mendel E, Sciubba D. Assessing a revised-risk analysis index for morbidity and mortality after spine surgery for metastatic spinal tumors. Journal Of Neuro-Oncology 2024, 1-16. PMID: 39320656, DOI: 10.1007/s11060-024-04830-z.Peer-Reviewed Original ResearchModified frailty index-5Length of stayRAI-revMetastatic spinal tumorsPredicting 30-day mortalityReceiver operating characteristicArea under the curveSpine surgeryFrail patientsSpinal tumorsNo significant differenceSpinal pathologyMultivariate analysisMethodsA retrospective cohort studySignificant differenceExtended length of stayReceiver operating characteristic analysisACS NSQIP databasePredictors of extended length of stayRetrospective cohort studyMultidisciplinary decision makingMetastatic diseaseNSQIP databasePatient ageSpinal surgeryImplications of surgical infection on surgical and hospital outcomes after spine surgery: A NSQIP study of 410,930 patients
Elsamadicy A, Serrato P, Sadeghzadeh S, Dietz N, Lo S, Sciubba D. Implications of surgical infection on surgical and hospital outcomes after spine surgery: A NSQIP study of 410,930 patients. Clinical Neurology And Neurosurgery 2024, 245: 108505. PMID: 39173491, DOI: 10.1016/j.clineuro.2024.108505.Peer-Reviewed Original ResearchExtended hospital length of stayNon-routine dischargeLength of staySurgical infectionsHospital length of stayExtended hospital lengthRetrospective cohort studySpine surgeryAdverse eventsStudy Design Retrospective cohort studyCohort studyPredictors of adverse eventsMultivariate logistic regression analysisRate of adverse eventsProlonged length of stayACS NSQIP databaseRisk of complicationsPostoperative adverse eventsHealthcare resource utilizationICD-9/10 codesLogistic regression analysisNon-home dischargeNSQIP studiesDesign Retrospective cohort studyMean BMIThe Impact of Preoperative Spinal Injection Timing on the Postoperative Complications of Lumbar Fusion
Mirpuri P, Khalid S, Colliander R, King P, Tao X, Elsamadicy A, Mehta A, Adogwa O. The Impact of Preoperative Spinal Injection Timing on the Postoperative Complications of Lumbar Fusion. World Neurosurgery 2024, 190: e121-e128. PMID: 39002778, DOI: 10.1016/j.wneu.2024.07.050.Peer-Reviewed Original ResearchTransforaminal lumbar interbody fusionCSF leakSurgical complicationsComplication rateIncidence of CSF leakRate of CSF leakSecondary outcomesRate of surgical complicationsSurgical complication ratePostoperative surgical complicationsSurgical site infectionDay of surgeryLumbar interbody fusionPostoperative complicationsSite infectionWound disruptionPostoperative rateAdult patientsLumbar fusionInterbody fusionIncreased riskPrimary outcomePatientsSurgeryPrimary analysisRegional variations in morbidity and mortality among neonates with intraventricular hemorrhage: a national database analysis
Sayeed S, Theriault B, Hengartner A, Serrato P, Sadeghzadeh S, Belkasim S, Ahsan N, Elsamadicy E, DiLuna M, Elsamadicy A. Regional variations in morbidity and mortality among neonates with intraventricular hemorrhage: a national database analysis. Child's Nervous System 2024, 40: 1-10. PMID: 38955900, DOI: 10.1007/s00381-024-06514-5.Peer-Reviewed Original ResearchNational Inpatient SampleIntraoperative variablesLong-term neurodevelopmental outcomesLow gestational ageMultivariate logistic regression analysisPermanent CSF shuntNational database analysisLow birth weightPercentage of patientsRetrospective cohort studyAssociated with decreased oddsImpact of insurance statusAssociated with reduced oddsMedian total costAssociated with mortalityLogistic regression analysisBackgroundIntraventricular hemorrhageNeonatal IVHGestational ageIntraventricular hemorrhageNeurodevelopmental outcomesCSF diversionCSF shuntingCost of admissionBirth weightImpact of Depression on Postoperative Medical and Surgical Outcomes in Spine Surgeries: A Systematic Review and Meta-Analysis
Aghajanian S, Shafiee A, Athar M, Mohammadifard F, Goodarzi S, Esmailpur F, Elsamadicy A. Impact of Depression on Postoperative Medical and Surgical Outcomes in Spine Surgeries: A Systematic Review and Meta-Analysis. Journal Of Clinical Medicine 2024, 13: 3247. PMID: 38892958, PMCID: PMC11172961, DOI: 10.3390/jcm13113247.Peer-Reviewed Original ResearchNon-routine dischargeSpine surgerySurgical complicationsSurgical outcomesStatistically significant higher rateUrinary tract infectionSurgical site infectionDeep vein thrombosisLength of hospitalizationSystematic reviewNon-depressed controlsSignificantly higher ratesUrinary retentionPostoperative medicationTract infectionsPostoperative outcomesPulmonary embolismSite infectionSpinal surgeryVein thrombosisImpact of depressionPooled analysisDepressed patientsHematoma formationHospital lengthInsurance Disparities in Patient Outcomes and Healthcare Resource Utilization Following Neonatal Intraventricular Hemorrhage
Sayeed S, Theriault B, Hengartner A, Ahsan N, Sadeghzadeh S, Elsamadicy E, DiLuna M, Elsamadicy A. Insurance Disparities in Patient Outcomes and Healthcare Resource Utilization Following Neonatal Intraventricular Hemorrhage. World Neurosurgery 2024, 189: e46-e54. PMID: 38815926, DOI: 10.1016/j.wneu.2024.05.136.Peer-Reviewed Original ResearchIntraventricular hemorrhagePI patientsInsurance statusAssociated with surgical delayDiagnosis of intraventricular hemorrhageMultivariate logistic regression analysisNeonatal intraventricular hemorrhageAssociated with increased healthcare utilizationNational Inpatient Sample databaseRetrospective cohort studyImpact of insurance statusTime to referralAssociated with increased oddsInpatient Sample databaseAssociation of insurance statusLogistic regression analysisLength of stayMyelomeningocele repairSurgical delayCost of admissionAdverse eventsPrivate insuranceCohort studyMedicaid patientsPI cohortSociodemographic Disparities and Postoperative Outcomes Following Cranial Vault Remodeling for Craniosynostosis: Analysis of the 2012 to 2021 NSQIP-Pediatric Database
Hengartner A, Serrato P, Sayeed S, Sadeghzadeh S, Prassinos A, Alperovich M, DiLuna M, Elsamadicy A. Sociodemographic Disparities and Postoperative Outcomes Following Cranial Vault Remodeling for Craniosynostosis: Analysis of the 2012 to 2021 NSQIP-Pediatric Database. Journal Of Craniofacial Surgery 2024, 35: 1310-1314. PMID: 38752737, DOI: 10.1097/scs.0000000000010303.Peer-Reviewed Original ResearchNon-Hispanic blacksNon-Hispanic whitesLength of stayCranial vault repairAdverse eventsNational Surgical Quality Improvement Program-Pediatric databaseAmerican College of Surgeons National Surgical Quality Improvement Program Pediatric databaseMultivariate logistic regression analysisNSQIP-Pediatric databaseAge of presentationNon-Hispanic Black patientsNon-Hispanic white patientsIncreased complication rateHospital length of stayExtended length of stayPostoperative clinical outcomesEquitable health careRetrospective cohort studyCranial vault remodelingCurrent Procedural Terminology codesPostoperative adverse eventsCranial vault reconstructionProcedural Terminology codesLogistic regression analysisNon-white patientsEfficacy and utility of antifibrinolytics in pediatric spine surgery: a systematic review and network meta-analysis
Aghajanian S, Mohammadifard F, Kohandel Gargari O, Naeimi A, Bahadorimonfared A, Elsamadicy A. Efficacy and utility of antifibrinolytics in pediatric spine surgery: a systematic review and network meta-analysis. Neurosurgical Review 2024, 47: 177. PMID: 38644447, DOI: 10.1007/s10143-024-02424-x.Peer-Reviewed Original ResearchConceptsNetwork meta-analysisRate of complicationsBlood lossSpine surgeryEpsilon-aminocaproic acidMeta-analysisTranexamic acidEfficacy of antifibrinolyticsPediatric spine surgeryPerioperative blood lossReduce blood lossStandardized outcome dataRandomized clinical trialsStandard of carePerioperative bleedingTransfusion volumeTransfusion rateAntifibrinolytic agentsMassive transfusionPediatric patientsSafety profilePediatric surgeryProbability of efficacyAntifibrinolyticsClinical trials167 Association Between Safety-net Hospital Status and Postoperative Outcomes Following ACDF or PCDF for Cervical Spondylotic Myelopathy
Elsamadicy A, Sayeed S, Craft S, Sherman J, Reeves B, Koo A, Khalid S, Lo S, Shin J, Mendel E, Sciubba D. 167 Association Between Safety-net Hospital Status and Postoperative Outcomes Following ACDF or PCDF for Cervical Spondylotic Myelopathy. Neurosurgery 2024, 70: 40-40. DOI: 10.1227/neu.0000000000002809_167.Peer-Reviewed Original ResearchCervical spondylotic myelopathyNon-routine dischargeSafety-net hospital statusSafety-net hospitalACDF cohortSpondylotic myelopathyPostoperative outcomesAdverse eventsMultivariate analysisPosterior cervical decompressionAnterior cervical discectomyImpact postoperative outcomesProportion of patientsNational Inpatient Sample databaseRetrospective cohort studyPredictors of prolonged LOSInpatient Sample databaseNon-SNHsElective ACDFCervical decompressionCervical discectomyStudy patientsIndependent predictorsAdult patientsACDF726 Changes of Reported Industry Payments to Neurosurgeons Pre- and Post-Covid-19 Epidemic
Elsamadicy A, Cross J. 726 Changes of Reported Industry Payments to Neurosurgeons Pre- and Post-Covid-19 Epidemic. Neurosurgery 2024, 70: 164-164. DOI: 10.1227/neu.0000000000002809_726.Peer-Reviewed Original ResearchIsolated unilateral alar ligamentous injury: illustrative cases
Reeves B, Valcarce-Aspegren M, Robert S, Elsamadicy A, Tucker A, Storm P, DiLuna M, Kundishora A. Isolated unilateral alar ligamentous injury: illustrative cases. Journal Of Neurosurgery Case Lessons 2024, 7: case23664. PMID: 38560931, PMCID: PMC10988229, DOI: 10.3171/case23664.Peer-Reviewed Original ResearchMagnetic resonance imagingCervical collarAdequate first-line treatmentAlar ligament injuryUpper cervical traumaMagnetic resonance imaging evidenceHard cervical collarRigid cervical collarFirst-line treatmentResolution of symptomsRigid external immobilizationNeck painNeck tendernessCervical traumaHalo fixationPediatric patientsDefinitive diagnosisNonsurgical managementCervical radiographsModerate courseFollow-upLigament strainExternal immobilizationOdontoid processPatientsReduced racial disparities among newborns with intraventricular hemorrhage
Sayeed S, Reeves B, Theriault B, Hengartner A, Ahsan N, Sadeghzadeh S, Elsamadicy E, DiLuna M, Elsamadicy A. Reduced racial disparities among newborns with intraventricular hemorrhage. Child's Nervous System 2024, 40: 2051-2059. PMID: 38526575, DOI: 10.1007/s00381-024-06369-w.Peer-Reviewed Original ResearchLength of stayIntroductionIntraventricular hemorrhageAdverse eventsMultivariate logistic regression analysisRate of adverse eventsPermanent neurological dysfunctionProlonged length of stayNational Inpatient Sample databaseRates of NECInpatient Sample databaseLogistic regression analysisIntraventricular hemorrhageAA patientsImpact of raceCost of admissionIndependent predictorsRate of mortalityPatient characteristicsMultivariate analysisPercentage of AAWhite patientsNeurological dysfunctionNewbornsPatient genderPatientsVariations in the genomic profiles and clinical behavior of meningioma by racial and ethnic group.
Tabor J, Dincer A, O'Brien J, Lei H, Vetsa S, Vasandani S, Jalal M, Yalcin K, Morales-Valero S, Marianayagam N, Alanya H, Elsamadicy A, Millares Chavez M, Aguilera S, Mishra-Gorur K, McGuone D, Fulbright R, Jin L, Erson-Omay E, Günel M, Moliterno J. Variations in the genomic profiles and clinical behavior of meningioma by racial and ethnic group. Journal Of Neurosurgery 2024, 141: 664-672. PMID: 38518289, DOI: 10.3171/2024.1.jns231633.Peer-Reviewed Original ResearchBlack patientsSporadic meningiomasClinical outcomesGenomic profilingClinical behavior of meningiomasShorter progression-free survivalAnterior skull base tumorsClinical data of patientsHispanic patientsProgression-free survivalChromosome 1p deletionBehavior of meningiomasIncreased recurrence rateRate of recurrenceSkull base tumorsData of patientsSomatic driver mutationsNon-Black patientsShorter PFSOverall survivalAggressive meningiomasTRAF7 mutationsIntracranial meningiomasMeningioma resectionNon-black groupDecompression Alone Versus Interspinous/Interlaminar Device Placement for Degenerative Lumbar Pathologies: Systematic Review and Meta-Analysis
Pennington Z, Lakomkin N, Mikula A, Elsamadicy A, Astudillo Potes M, Fogelson J, Grossbach A, Elder B. Decompression Alone Versus Interspinous/Interlaminar Device Placement for Degenerative Lumbar Pathologies: Systematic Review and Meta-Analysis. World Neurosurgery 2024, 185: 417-434.e3. PMID: 38508384, DOI: 10.1016/j.wneu.2024.03.054.Peer-Reviewed Original ResearchPatient-reported outcomesDecompression-aloneDegenerative lumbar pathologyPain improvementInterlaminar deviceLumbar pathologySF-36 physical component scoreLeg pain improvementDisease-specific patient-reported outcomeBack pain improvementPhysical component scorePhysical function scoresTotal care costsEQ-5D scoresTotal treatment costsSymptom severity scoresReoperation ratePerioperative complicationsConventional surgerySF-36Care costsFollow-upComponent scoresSeverity scoreDevice placementImpact of a quality improvement initiative and monthly multidisciplinary meetings on outcomes after posterior spinal fusion for adolescent idiopathic scoliosis
Hengartner A, Elsamadicy A, Jonnalagadda A, Craft S, Sherman J, Reeves B, Fernandez T, Hobbs J, Koo A, DiLuna M, Tuason D. Impact of a quality improvement initiative and monthly multidisciplinary meetings on outcomes after posterior spinal fusion for adolescent idiopathic scoliosis. Spine Deformity 2024, 12: 1043-1051. PMID: 38493442, DOI: 10.1007/s43390-024-00859-2.Peer-Reviewed Original ResearchPosterior spinal instrumented fusionPre-QI cohortAdolescent idiopathic scoliosisMultidisciplinary team meetingsProportion of patientsLength of stayPre-QITeam meetingsPost-QIPostoperative complicationsIdiopathic scoliosisQuality improvementQuality improvement initiativesPostoperative ambulationBenefits of enhanced recoveryMethodsThe medical recordsPain control protocolIntraoperative drain placementPosterior spinal fusionSpinal instrumented fusionQI implementationImprovement initiativesPatient careAmbulation statusDrain placement