Predictors of survival and time to progression following operative management of intramedullary spinal cord astrocytomas
Hersh AM, Antar A, Pennington Z, Aygun N, Patel J, Goldsborough E, Porras JL, Elsamadicy AA, Lubelski D, Wolinsky JP, Jallo GI, Gokaslan ZL, Lo SL, Sciubba DM. Predictors of survival and time to progression following operative management of intramedullary spinal cord astrocytomas. Journal Of Neuro-Oncology 2022, 158: 117-127. PMID: 35538385, DOI: 10.1007/s11060-022-04017-4.Peer-Reviewed Original ResearchConceptsProgression-free survivalPredictors of survivalHigh tumor gradeResection extentTumor gradePoor survivalIntramedullary spinal cord astrocytomasPost-operative neurologic deficitsSingle comprehensive cancer centerTumor progression/recurrencePre-operative presentationPreoperative back painSpinal cord astrocytomasKaplan-Meier curvesProgression/recurrenceStandard of careComprehensive cancer centerLong-term survivalPurposeSurgical resectionBowel dysfunctionChemotherapy regimensNeurologic deficitsIntramedullary astrocytomasPatient demographicsComplete resectionPerioperative outcomes and survival after surgery for intramedullary spinal cord tumors: a single-institution series of 302 patients.
Hersh AM, Patel J, Pennington Z, Porras JL, Goldsborough E, Antar A, Elsamadicy AA, Lubelski D, Wolinsky JP, Jallo G, Gokaslan ZL, Lo SL, Sciubba DM. Perioperative outcomes and survival after surgery for intramedullary spinal cord tumors: a single-institution series of 302 patients. Journal Of Neurosurgery Spine 2022, 37: 252-262. PMID: 35213831, DOI: 10.3171/2022.1.spine211235.Peer-Reviewed Original ResearchIntramedullary spinal cord tumorsLong-term survivalPerioperative outcomesSpinal cord tumorsSingle-institution seriesFisher's exact testChi-square testCervical cordCord tumorsClinical presentationTumor histologyAmerican Spinal Injury Association gradeExact testPrimary intramedullary spinal cord tumorsTumor pathologyShort-term clinical coursePoor long-term survivalLarge single-institution seriesBaseline neurological statusHigh-grade ependymomasCohort of patientsGross total resectionExtent of resectionLog-rank testLength of stay