2017
Single-Cell Metabolomics by Mass Spectrometry for Drug Discovery: Moving Forward
K R, T W, SF N, AV W. Single-Cell Metabolomics by Mass Spectrometry for Drug Discovery: Moving Forward. Drug Designing Open Access 2017, 6: 1-5. DOI: 10.4172/2169-0138.1000149.Peer-Reviewed Original ResearchSingle-cell metabolomicsMolecular levelSingle-cell isolationCellular functionsCellular statesOmics approachesFunctional screenMetabolite poolsCell metabolomicsCellular interactionsBiological researchMass spectrometryCell sortingDrug discoveryMetabolomicsTandem mass spectrometryDrug developmentMetabolomics researchConcentrations of metabolitesEnvironmental influencesComprehensive understandingComprehensive informationSortingFuture prospectsCells
2010
Antigenic changes in human albumin caused by reactivity with the occupational allergen diphenylmethane diisocyanate
Wisnewski AV, Liu J, Redlich CA. Antigenic changes in human albumin caused by reactivity with the occupational allergen diphenylmethane diisocyanate. Analytical Biochemistry 2010, 400: 251-258. PMID: 20123080, PMCID: PMC3106273, DOI: 10.1016/j.ab.2010.01.037.Peer-Reviewed Original ResearchConceptsHigh-performance liquid chromatographyDiphenylmethane diisocyanateConjugation sitesReaction productsCross-linking agentTandem mass spectrometryPolyurethane productionMass spectrometryMDI-exposed workersCause of asthmaHuman albuminSerum immunoglobulin GLiquid chromatographyReaction specificityDiisocyanateSecond lysineMDI conjugationAirway inflammationAnalytical methodSelf proteinsProteomic methodologiesEpitope specificityAntigenic changesClinical researchConjugates